Objective To investigate the genotype of Trp64Arg polymorphism of β3-adrenergic receptor gene and analyze the role ofβ3-adrenerglc receptor gene in the pathogenesis of morbid obesity and metabolic syndrome(MS).Methods PCR-restriction fragment length polymorphism Was used to detect the genotypes of 172 patients with MS,92 patient.with morbid obesity and 92 controls,and some biochemlcal indexes were detected.The association of the polymorohism with morbid obesity and MS Was assessed in case-control study.Resuits No statistically significant differences were found in the frequencies of Trp64Arg of β3-AR among the three groups.Conclusion Trp64Arg polymorphism of β3-AR was not significandy associated with morbid obesity and MS in the Hazak in xinjiang.

ssociation of snoring with metabolic syndrome in the four ethnic populations in Boertala region of Xinjiang.

Objective To determine the relationship between neck circumference (NC) and cardiovascular risk factors among Uygur,Kazak,Mongolian and Han populations in Boertala Mongol Autonomous Prefecture of Xinjiang.Methods A total of 4299 adults (Uygur 1237,Kazak 1047,Mongolian 812,and Han 1203) aged 20 to 79 years old were selected from a cross-sectional study of metabolic syndrome in Boertala Mongol Autonomous Prefecture of Xinjiang.Pearson's correlation was used to assess the relationship between NC and body mass index (BMI),waist circumference (WC),waist-to-hip ration (WHR),systolic blood pressur (SBP),diastolic blood pressure (DBP),fasting blood glucose (FBG),total cholesterol (TC),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG).Linear regression and Logistic regression were used to evaluate the effects of NC on SBP,DBP,FBG,TC,LDL-C,HDL-C,TG,hypertension,high FBG and lipid disorders among multiethnic population.Results Mean NC was (36.2 ± 3.8) cm in Uygur,(36.3 ± 4.1) cm in Kazak,(35.9 ± 3.6) cm in Mongolian and (35.7 ± 4.0) cm in Han,respectively.After adjusting age and gender,in Pearson's correlation coefficients,a significant association was found between NC and BMI (for Uygur,Kazak,Mongolian and Han,r values were 0.552,0.499,0.709 and 0.459,respectively; all P ＜ 0.05) or WC (for Uygur,Kazak,Mongolian and Han,r values were 0.525,0.479,0.695 and 0.376,respectively; all P ＜ 0.05).When BMI,WC and other factors were adjusted,linear regression indicated that FBG in Uygur (t =3.746,P ＜ 0.05) and LogTG in Mongolian (t =2.876 P ＜ 0.05) were increased with NC.In Logistic regression,increased NC was a risk factor of higher FBG in Uygur (odds ratio (OR) =1.139,95％confidence interval (CI):1.027-1.264) and lipid disorder in Mongolian (OR =1.156,95％ CI:1.009-1.325).Conclusions Our data suggest that NC may be associated with multiple risk factors of cardiovascular disease in Uygur,Kazak,Mongolian and Han adults,and the relationship could be different among multiethnic populations.It should be necessary to explore the role of upper-body fat in the development of metabolic disorders.

Objective To reveal the distribution characteristics of serum lipids,lipoproteins,and apolipoproteins levels in different nationalities.Methods Quantitative levels of those traits mentioned above were determined and body height(H),weight(W)and body mass index(BMI=W/H2)were assessed in 773 Kazaks(men 360 and women 413)and 911 Han nationality(men 466 and women 445)from the Xinjiang Autonomous Region of China.Results Kazaks men and women,respectively,had significantly higher serum levels of HDL-c and ApoA1 (all P ＜ 0.001)and significantly lower serum levels of TG(men P ＜ 0.01,women P ＜ 0.001),Lp(a)(allP＜0.005),ApoB(men P＜0.005,women P＜0.001)and ApoB/A1(men P＜0.01,women P＜0.001)than their Han nationality controls.The threshold points of ApoA1(＜ 1.2 g/L)and ApoB(＞ 1.2 g/L)are higher in Hans than in Kazaks for ApoA1(20.7 vs 9.8%)and ApoB(18.6 vs 14.3%);the serum levels of TG,HDL-c,Lp(a),ApoA1 and ApoB/A1 are all closely correlated with nationality(P ＜ 0.001,P = 0.001,and P ＜ 0.05,respectively).Conclusion The results suggest that the nationality differences exist in serum levels of lipids,lipoproteins,and apolipoproteins,and Kazaks have a superior serum lipid pedigree to Hans.This differences may come from genetic differences,which affect the serum levels of lipids,lipoproteins,and apolipoproteins by controlling lipid metabolism pattems.Future study will be needed to dissect to the role of genetic factors on serum lipids.