1.Effect of Kebimin Spray on Substan on Substance P Contents in Lung and Plasma of Guinea Pigs with Hhypersensitive Rhinitis
Yanfang QIAN ; Bingwen LI ; Zhengmou ZHOU ; Yanyan BAO ; Jinrang LI
Journal of Guangzhou University of Traditional Chinese Medicine 1999;0(02):-
To study the antisensitiZation of Chinese drug, Inodel gUinea pigS with hypersensitive thinilistabbed with Kebindn Sray Served as Group l, and substance P(SP) contents in lung and plasma ofGroup I were detected and compared with normal coned group (Group 11),model control groUp(Group ill) and poSitive medicine control group(GrouP ac).The resultS showed that SP content inlung and plasma of Group ill were higher than thais of GrouP 11(P 0.05).SP is an active neuropeptide and over release of SP Inay result in hperetion of the nose.It is indicated that Kebimin SPlaycan inhibit type I alleds by decreasing SP contents in lung and plasma.
2.Development and validation of a FE model in swine mandibular composite tissue of fragment injury
Jingfu WANG ; Junqi JIA ; Lei TIAN ; Jin LI ; Bingwen QIAN ; Lisheng HE
Journal of Practical Stomatology 2018;34(1):16-20
Objective: To establish and verify the validity of a finite element(FE) model of fragment injury in swine mandibular composite tissue. Methods: Swine facial composite tissue digital information was obtained by 3D CT,the 3D model and the cylinder fragment with the diameter and height of 5. 5 mm were reconstructed and designed in mimics15. 0. The right mandibular angle region was impacted by the fragment with velocities in finite element analysis software. A two stage light gas gun was used to launch the same shape 30CrMnSi alloy fragment with the speed of 831,1 120 and 1 536 m/s respectively to impact swine mandibular angle area. The actual damage area and acceleration at jaw were measured and compared with the digital simulation results. Results: Compared with the data of digital simulation the fragment with the speed of 831,1 120 and 1 536 m/s resulted in the larger mandibular damage area of entry in the in vivo experiment by 13. 4%,23. 6% and 22. 3%; that of exit by 18. 7%,23. 0% and 26. 5%; the smallar accelaration peak by 16. 7%,15. 3% and 14. 6%,respectively. Conclusion: A digital model of the swine mandible composite tissue fragment injury model is established. The simulation results of the FE model are consistent similar to those of the in vivo test data.