1.Oxidized low density lipoprotein induces the human peripheral blood monocyte expression of proinflammatory cytokines mRNA
Xinjun LEI ; Aiqun MA ; Bingwen REN ; Tao GENG ; Wei ZHANG
Chinese Journal of Immunology 1985;0(02):-
Objective:To investigate the function of oxidized low density lipoprotein(OxLDL) in the formation of atherosclerotic immuno-pathological lesions in the local blood vessel.Methods:With the Digoxenin-labeled Oligonucleotide-probes In Situ Hybridization,studied the effects of OxLDL on the mRNA expression of proinflammatory cytokines including MCP-1, bFGF, PDGF and IL-10 in the human peripheral blood monocyte. Results:Monocyte was significantly increased the mRNA expression of MCP-1, bFGF, PDGF and IL-10 in a dose-dependent manner after incubating with OxLDL(10~30 mg/L)for 24 hours(P
2.Serum concentrations of laminin and fibronectin in patients with acute coronary syndromes
Xiaojun BAI ; Aiqun MA ; Yutao XI ; Geru WU ; Bingwen REN
Journal of Pharmaceutical Analysis 2008;20(2):88-91
Objective To study the serum iaminin (LN) and fibronectin (FN) changes in acute coronary syndromes (ACS), and explore the role of them in assessing the severity of ACS. Methods This study included 46 ACS patients [25 with acute myocardial infarction (AMI) and 21 with unstable angina (UA)], 51 stable angina (SA) patients and 47 people without CHD as controls. Serum levels of LN, FN, fibrinogen and blood fat were assessed. Coronary angiography were performed on 49 of them. Results The serum concentration of LN was lower in ACS patients [(85.20±27. 57)ng/mL], higher in SA patients [(116. 80 ± 28. 80)ng/mL] as compared to that in the control group [(100.06±29.96)ng/mL], with significant difference among the groups (P<0.05). No difference was found in FN among the three groups. However, the subgroup analysis in the group with ACS showed that the serum concentration of FN was significantly higher in UA patients [(229.60±121.39)μg/mL ], and lower in AMI patients [(108.31±47.12) μg/mL ]. The serum LN and FN concentration could respectively enter the logistic regression equations of ACS patients and US patients. Neither LN nor FN concentration was correlated with narrowing of coronary artery of angiography. Conclusion Serum LN and FN level may be a useful indicator for stability of atherosclerosis plaque in coronary arterial disease patients, but could not predict the extent of narrowing in coronary angiography.
3.Preliminary study of fogging process for fixing high-concentration radioactive aerosol 131I contamination in a radiopharmaceutica production unit
Shuai GAO ; Haitao QIAO ; Jing ZHANG ; Pei HU ; Hongpeng SHUAI ; Huilong YIN ; Bingwen MA
Chinese Journal of Radiological Health 2021;30(2):165-167
Objective To prove the feasibility of a Fogging Process in fixing high-concentration radioactive aerosol 131I contamination. Methods High-concentration radioactive aerosol 131I contamination in an 131I-operating glovebox for radiopharmaceutical production was disposed by using fogging and fixing process. The aerosol 131I concentrations were detected and the results were analyzed. Results After a 120 minutes fixing, the 131I contamination in this glovebox reduced from(289 ± 9) DAC and (304 ± 6) DAC to (21.7 ± 2.0) DAC and (26.2 ± 1.8) DAC. After a 180 minutes fixing, the 131I contamination in this glovebox reduced from (259 ± 10) DAC to (1.80 ± 0.18) DAC. These results showed that no aerosol 131I contamination was raised again after 24-hours finishing this task. Conclusion Aerosol 131I concentration in a limited space could be controlled by using a fogging and fixing process, which could reduce the risk of internal exposure of staff. This process could be used by radiopharmaceutical production as an emergency management for dispose high-concentration radioactive aerosol 131I contamination.