Objective To observe the clinical efficacy of electroacupuncture plus ginger-partitioned moxibustion in treating sudden hearing loss. Method Sixty patients with sudden hearing loss were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by electroacupuncture plus ginger-partitioned moxibustion, while the control group was by electroacupuncture alone. The audiometry was conducted before and after intervention, and the therapeutic efficacy was also evaluated.Result Respectively after the first and second treatment course, the threshold of audibility was significantly changed in both groups (P<0.05); there were significant differences in comparing the threshold of audibility between the two groups (P<0.05). The total effective rate was 80.0% and 90.0% respectively after the first and second treatment course in the treatment group, versus 53.3% and 63.3% in the control group, and the differences were statistically significant (P<0.05).Conclusion Electroacupuncture plus ginger-partitioned moxibustion is an effective approach in treating sudden hearing loss.

Based on the kinetics of alcohol metabolism in animal models,the mathematicalmode for studing of the alcohol kinetics in person of the acute alcohol poisoningwas established.This mathematical mode can be expressed as x(t)=x_0(1-e~(-kat))-k_bt,which allows calculating the absorpion constant (k_a) arld breakdown rate constant(k_b) for alcohol the curve in dynamic change of the alcohol concentration followingadministration of a large amount of alcohal can be obtained the amount of alcoholin human body [x,(t)] after drinking can be checked out.from the urine Theexperimental study in monkeys showed that the parameters derived from the mathe-matical mode agued witk the results obtained from the experiments

Objective To evaluate the abilities of plasma perfusion and plasma exchange to remove blood endotoxin and cytokines from hepatic failure patients. Methods Plasma perfusion and plasma exchange were performed on 7 cases and 10 cases for the treatment of chronic severe hepatitis, respectively. Changes of blood endotoxin and cytokines before and after treatment were analyzed. Results The levels of cytokines and endotoxin in patient blood decreased greatly, but bilirubin decreased slightly after treatment with plasma perfusion. The changes of interleukin 6 were very limited. Compared with plasma perfusion, the removal of bilirubin was higher but that of cytokines was lower after plasma exchange. Conclusion Plasma perfusion can remove cytokines with high efficiency and retard the development of hepatic failure.

OBJECTIVE: To observe the clinical effect of Chinese medicine Sansheng Huatan Decoction combined with chemotherapy in treating advanced primary non-small-cell lung cancer and to evaluated the effect of Sansheng Huatan Decoction increasing clinical effect and decreasing toxicity in chemotherapy for non-small-cell lung cancer. METHODS: One hundred and sixty patients of advanced primary non-small-cell lung cancer proved by pathological examination were randomized into two groups. The treatment group was treated with Sansheng Huatan Decoction and chemotherapy, and the control group was treated only with chemotherapy. The clinic effect, life quality, natural killer (NK) activities, liver and kidney functions, and blood routine test of the 2 groups were evaluated. RESULTS: The clinical effective rates of the treatment and control groups were 56.7% and 48.2% respectively, and there was no statistic significance (P>0.10). The life quality, NK activities and blood routine test of the treatment group were better than those of the control group. CONCLUSION: Sansheng Huatan Decoction combined with chemotherapy is a better treatment for non-small-cell lung cancer as compared with chemotherapy.

Microcirculation dysfunction is involved in the onset of diabetes and its complications.The pathophysiological mechanisms behind the relationship between microcirculation and diabetes are multifactorial.Islet microcirculation dysfunction affects function of islet β cells.Impairment of microvascular vasomotion might be associated with insulin resistance.Microcirculation dysfunction of target organs mediates diabetic complications.

Objectives: To determine the regulation effects of recombinant human growth hormone(rhGH) on dipeptide transport(PepT1) in normal and severe scalded rats. Methods: Male Sprague Dawley rats inflicted by 30% total body surface area ( TBSA) Ⅲ degree scalding were employed as the model.The rhGH was used in this study with the dose of 2 U/(kg?d). An everted sleeve of intestine was incubated in Kreb’s solution with radioactive dipeptide ( 3 H Glycylsarcosine, 3 H Gly Sar, 10 ?Ci / ml) at 37℃ for 15 min to measure the effects of uptake and transport of PepT1 of small intestinal epithelial cells in normal and severe scalded rats. Results: The transport of dipeptide in normal rats with injection of rhGH was not significantly increased compared with controls ( P =0.192 6) while the uptake was significantly increased compared with controls ( P = 0.025 3 ). The transport and uptake of PepT1 in scalded rats with injection of rhGH were significantly increased compared with controls( P = 0.008 2 and 0.039 1). Conclusions: The effects of uptake and transport of dipeptide transporters in small intestinal epithelial cells with severe injury were markedly upregulated by rhGH.

Objective: To carry out the native assessment of International Affective Picture System(IAPS) among Chinese older adults.Methods:Altogether 116 Chinese older adults,including 51 male and 65 female,from three communities in Dalian City,aged from 60 to 80 years,rated 60 pictures(positive:25,neutral:12,negative:23) selected from the IAPS in terms of valence,arousal and dominance with Self-Assessment Manikin(SAM).The mean affective ratings were compared to the normative ratings of USA National Institute of Mental Health(NIMH).Result: Reliability analysis indicated that the affective ratings of our sample were stable and highly internally consistent.The affective ratings of Chinese older participants were strongly correlated with the normative ratings of NIMH(r=0.92,0.54 and 0.88 respectively for valence,arousal and dominance,P0.05).Conclusion: IAPS is highly internationally accessible just as the expectation of its designers.However,considering about great differences in many aspects such as culture,social living and age between Chinese aged and NIMH sample,they may have different affective experiences to the same emotional stimuli.Therefore it is necessary to do some revisal before the IAPS is applied to Chinese aged.

Objective To explore the clinical efficacy of modified single-portlaparoscopic radical prostatec-tomy(LRP) by atransperitoneal or extraperitoneal approach, and the impact of either approach on immune function in patients with prostate neoplasms. Methods The clinical data on 39 patients who had undergoneextraperitoneal LRP(group A) and 20 patients who had receivedtranperitoneal LRP (group B) in our department from January 2012 to December 2015 were retrospectivelyanalyzed. The prostate neoplasms were preoperatively diagnosed as cancer by ultrasound, CT or MRI, and pathological examinations. The clinical stage was T1-T2c , N0M0 in all patients.The efficacy was assessed by surgical duration, intraoperative blood loss, timeto intestinal function recovery, and post-operative hospital stay in both groups. The indicators for immune function including prostate specific antigen (TPSA and FPSA), immunoglobulin (IgG, IgA, lgM, C3, and C4) and T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+/CD8+) in patientswith prostate neoplasms before and after surgery were detected. Results 59 patients were operat-ed successfully, without converting to open approach. The mean surgical duration, blood loss, time to intestinal function recovery, and postoperative hospital stay were (133.8 ± 68.6) min, (75.6 ± 51.3) mL, (2.2 ± 0.7) days, and (14.7 ± 3.6) days in group A, while (159.4 ± 78.1) min, (102.2 ± 70.8) mL, (2.9 ± 1.1) days, and (15.2 ± 4.1) days in group B. There were significant differences between the two groups (P<0.05). After surgery, levels of IgG, IgA, C3, C4, CD3+, CD4+and CD4+/CD8+were significantly higherin group Athan in group B (P < 0.05). There were no significant differences between the two groups in levels of TPSA, FPSA and lgM (P>0.05). Average postoperative follow-up was 15 months (range 3-36) in 36 patients. No recurrence or metastasis was found in all the patients by imaging studies,and no long-term complications were found. Conclusions Extraperitoneal LRP, as compared with tranperitoneal LRP, has clearer vision, fewer effects on abdominal organs, shorter surgical duration, less blood loss, faster postoperative recovery, and better protection of immune function. It is worth popularizing clin-ically.

Objective To investigate cognitive strategies of emotion regulation in subjects with panic disorder (PD).Methods Subjects were 51 patients with PD and 54 healthy controls individually matched by age,sex and educational level.Cognitive Emotion Regulation Questionnaire (CERQ) were obtained from both panic and control group.Twenty-three panic disorder patients and 22 healthy controls completed a validated passive cognitive reappraisal task.Results (1) PD group scored significantly lower on the strategies of positive focus (4.4± 1.3 vs 5.4±1.3),positive reappraisal (4.9±2.0 vs 6.5±2.0) and putting into perspective (4.8±1.8 vs 6.2±1.9),and significantly higher on the strategies of catastrophizing (7.1 ±2.0 vs 4.5± 1.8) and rumination (6.8±2.2 vs 3.9± 1.9)than control group (P＜0.05).(2) In cognitive reappraisal task,significant picture type × group interactions were found in both valence and arousal 9-point scales (P＜0.05).Conclusion PD patients show obvious impairment of emotion regulation,and cognitive reappraisal defect may play an important role in it.

ObjectiveTo study the role of Kukoamine B (KB) in inhibiting the inflammatory response of small intestine in septic mice and its molecular mechanisms.Methods Twenty-four male ICR mice were randomly divided into control group, model group, and KB intervention group (each,n= 8). Sepsis model was reproduced by intra-peritoneal injection of 20 mg/kg lipopolysaccharide (LPS), while equivalent normal saline was given in control group, and 20μg/kg KB was injected through caudal vein 4 hours after LPS challenge in KB intervention group. The blood/tissue samples (jejunum and ileum) were harvested 8 hours after LPS injection. The levels of plasma LPS, tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) were measured. The pathological changes in small intestine tissues were observed under light microscope, while the levels of inflammatory cytokines TNF-α and IL-1β in the tissue homogenates (jejunum and ileum) were assessed by enzyme linked immunosorbent assay (ELISA). The activity of myeloperoxidase (MPO) was measured by colorimetry. The expression of intercellular adhesion molecule-1 (ICAM-1) was determined by immunohistochemistry. The expressions of inducible nitric oxide synthase (iNOS) mRNA was assayed by reverse transcription-polymerase chain reaction (RT-PCR). The activation of nuclear factor-κΒ (NF-κΒ) was determined by Western Blot.Results The mice in model group were found to have an increase in microvascular permeability, interstitial edema, and infiltration of white blood cells, and the levels of LPS, TNF-α and IL-1β in their plasma, with an increase in concentrations of TNF-α and IL-1β, activity of MPO, positive expression of ICAM-1, expression of iNOS mRNA and NF-κB protein in small intestine (jejunum and ileum). Compared with model group, in mice with KB intervention, microvascular permeability, interstitial edema, and infiltration of white blood cells were reduced significantly, while the levels of LPS, TNF-α and IL-1β in plasma, the concentration of TNF-α and IL-1β, the activity of MPO, the positive expression of ICAM-1, the expression of iNOS mRNA and NF-κB protein in small intestine (jejunum and ileum) were significantly decreased [plasma LPS (kEU/L): 654.09±28.13 vs. 1 155.65±47.15, TNF-α (ng/L): 12.75±0.47 vs. 30.61±0.71, IL-1β (ng/L): 53.06±5.32 vs. 64.47±2.61; jejunum TNF-α(ng/L): 43.27±1.20 vs. 64.82±2.09, IL-1β (ng/L): 326.38±14.47 vs. 535.22±13.48, MPO (U/g): 0.14±0.01 vs. 0.32±0.02, iNOS mRNA (2-ΔΔCt): 2.39±0.13 vs. 10.80±0.22, NF-κB protein (gray value): 0.687±0.062 vs. 1.404±0.046; ileum TNF-α (ng/L): 62.75±3.92 vs. 104.24±2.82, IL-1β(ng/L): 408.06±1.70 vs. 521.97±1.16, MPO (U/g): 0.36±0.08 vs. 0.66±0.05, iNOS mRNA (2-ΔΔCt): 1.65±0.11 vs. 3.59±0.29, NF-κB protein (gray value):0.830±0.114 vs. 1.609±0.051, allP< 0.05].Conclusion KB can combine with LPS and inhibit LPS/Toll-like receptor 4 (TLR4) signaling pathway, thereby significantly inhibit the inflammatory response and protect the function of the small intestine in LPS-induced septic mice.