1. Reducing maternal parenting stress of children with autism spectrum disorder: father′s involvement
Chunchun HU ; Yun LI ; Bingrui ZHOU ; Chunxue LIU ; Chunyang LI ; Ying ZHANG ; Qiong XU ; Xiu XU
Chinese Journal of Pediatrics 2017;55(5):355-359
Objective:
To explore the relationship between fathers′ nursing time and maternal parenting stress of children with autism spectrum disorder(ASD).
Method:
Mothers of 98 ASD children who were first diagnosed in the department of Child Health Care, Children′s Hospital of Fudan University during June 2015 to January 2016 were included in the ASD group, with mothers of 92 typical children from a Community Maternal and Child Health Hospital and a kindergarten in the control group. The evaluation of parenting stress, parents′ nursing time and other related factors were cross-sectionally analyzed. Interview was conducted with the following tools: Parental Stress Index-Short Form(PSI-SF)for maternal parenting stress, and self-made General Parenting Information Questionnaire for nursing time of both parents and other related factors. The relationships were analyzed by Multiple Linear Regression analysis and Wilcoxon Rank-Sum test.
Result:
Maternal parenting stress of ASD children had a significant negative correlation with father′s nursing time in total score of parenting stress, PCDI domain and PD domain (
2.Organoids: approaches and utility in cancer research.
Bingrui ZHOU ; Zhiwei FENG ; Jun XU ; Jun XIE
Chinese Medical Journal 2023;136(15):1783-1793
Organoids are three-dimensional cellular structures with self-organizing and self-differentiation capacities. They faithfully recapitulate structures and functions of in vivo organs as represented by functionality and microstructural definitions. Heterogeneity in in vitro disease modeling is one of the main reasons for anti-cancer therapy failures. Establishing a powerful model to represent tumor heterogeneity is crucial for elucidating tumor biology and developing effective therapeutic strategies. Tumor organoids can retain the original tumor heterogeneity and are commonly used to mimic the cancer microenvironment when co-cultured with fibroblasts and immune cells; therefore, considerable effort has been made recently to promote the use of this new technology from basic research to clinical studies in tumors. In combination with gene editing technology and microfluidic chip systems, engineered tumor organoids show promising abilities to recapitulate tumorigenesis and metastasis. In many studies, the responses of tumor organoids to various drugs have shown a positive correlation with patient responses. Owing to these consistent responses and personalized characteristics with patient data, tumor organoids show excellent potential for preclinical research. Here, we summarize the properties of different tumor models and review their current state and progress in tumor organoids. We further discuss the substantial challenges and prospects in the rapidly developing tumor organoid field.
Humans
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Neoplasms/genetics*
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Organoids/pathology*
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Carcinogenesis
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Models, Biological
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Precision Medicine/methods*
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Tumor Microenvironment