Objective To investigate the influence of neutrophil-lymphocyte ratio (NLR) on radiosensitivity and prognosis,the relationship between NLR and clinical features,and the clinical value of NLR in patients with nasopharyngeal carcinoma (NPC).Methods 2006 to 2011 in the cancer center of Zhongshan University admitted to the newly diagnosed nasopharyngeal cancer patients in 266 cases.The association of pretreatment NLR with radiotherapy doses 20,40,and 60 Gy and therapeutic effect at 3 months after radiotherapy was analyzed,as well as the influence of NLR on overall survival (OS),local recurrence-free (LRF),and distant metastasis-free (DMF) rates.The Kaplan-Meier method was used to calculate survival rates and the log-rank test was used for survival difference analysis.Results NLR showed differences across patients with different T stages and sexes (P=0.039,0.032).The patients with NLR≤3 had significantly higher OS,LRF,and DMF rates compared with those with NLR＞ 3 (P=0.004,0.025,0.045).As NLR increased,the radiosensitivity in patients with NPC was reduced gradually,and radiosensitivity showed a significant difference between sensitive group and moderately sensitive group (P=0.043).When the radiotherapy dose was 40 Gy,the tumor regression group had a lower NLR than the residual tumor group (P=0.025).Conclusions In patients with NPC,an increased pretreatment NLR is an adverse prognostic factor,and NLR can be used as a simple and convenient method to evaluate the prognosis of patients with NPC.

OBJECTIVEBased on the different physiological characteristics of the mastoid skin and soft tissue of Chinese congenital microtia malformation, the Nagata two-stage method was respectively applied for ear reconstruction, and the clinic experience were investigated in this study.

METHODAccording to the mastoid skin and soft tissue difference in the thickness and tightness, 280 patients diagnosed with congenital microtia were divided into four types: thin and tight, thin and loose, thick and tight, thick and loose type. 90 cases of thin and loose type accepted the Nagata method of ear reconstruction surgery.

RESULTSWith average 7.8 months follow up, 84.4% (76/90) cases using Nagata two-stage method were satisfied with the outcome of the reconstructed ear including three dimensional position and subunit appearance. There were no postoperative complication related to chest wall deformity or affected normal physical function.

CONCLUSIONSThe Nagata two-stage method is appropriate management choice for Chinese congenital microtia. Based on the different physiological characteristics of the mastoid skin and soft tissue, the selection of different operational should be beneficial to the ear reconstruction of Chinese congenital microtia malformation.

China ; Congenital Microtia ; surgery ; Ear, External ; surgery ; Humans ; Mastoid ; Otologic Surgical Procedures ; Reconstructive Surgical Procedures ; Skin ; Thoracic Wall

Objective:To explore the effects of psychological suggestive therapy combined with diet restriction therapy on resilience and glycolipid metabolism in elderly patients with coronary heart disease and type 2 diabetes mellitus.Methods:A total of 200 elderly patients with coronary heart disease and type 2 diabetes mellitus were recruited from June 2017 to March 2019. They were divided into control group and study group according to the random number table method, with 100 cases each. However, during the whole research cycle, some patients affected by various factors dropped out of the study, and the final number of patients was 92 cases in the study group and 87 cases in the control group. The study group received psychological suggestive therapy combined with dietary restriction therapy on the basis of the control group. The psychoelasticity of patients was assessed by concise psychoelasticity scale by physicians trained before and after intervention, and the changes of glucose and lipid metabolism were investigated before and after intervention.Results:After intervention, the scores of resilience (19.39 ± 3.29), self-improvement (16.56 ± 3.00), optimism (15.02 ± 2.50) in the study group were higher than those in the control group (15.97 ± 3.77, 10.58 ± 2.40, 9.20 ± 3.12), with significant differences ( t value was 4.459, 6.762, 6.220, P < 0.05). After intervention, the blood glucose index of the study group was generally better than that of the control group. After intervention, FPG, 2hFPG and HbA1c in the study group were (5.02 ± 0.45) mmol / L, (8.94 ± 1.43) mmol / L, (5.87 ± 0.65)% respectively, and those in the control group were (6.29 ± 1.71) mmol / L, (9.65 ± 1.4) mmol / L, (7.21 ± 1.05)% respectively, with statistically significant differences ( t value was 4.682, 5.214, 5.696, P < 0.05). After intervention, ApoA1, TG, HDL-C and LDL-C were (1.58 ± 0.32)mmol/L, (1.61 ± 0.58)mmol/L, (2.11 ± 0.85)mmol/L, (2.09 ± 0.67) mmol / L in the study group, and in the control group ApoA1, TG, HDL-C and LDL-C were (1.13 ± 0.33)mmol/L, (1.98 ± 0.69)mmol/L, (1.82 ± 0.63)mmol/L, (2.71 ± 0.79) mmol/L respectively ( t value was 3.036-4.256, P < 0.05). Conclusion:Psychological suggestive therapy combined with dietary restriction therapy can effectively improve the resilience of elderly patients with coronary heart disease and type 2 diabetes mellitus, control the level of glycolipid metabolism, stabilize the condition and promote early recovery.

Objective: To explore a 1∶1 2D printing method of rib cartilage based on CT scanning in assisting ear framework fabrication for auricular reconstruction. Methods: From January 2016 to January 2017, 73 cases of microtia aging from 5 to 7 referred to our department. A 1∶1 2D printing of rib cartilage based on CT scanning was applied in preoperative assessment and measurments of bilateral sixth, seventh and eighth costal cartilage were completed before the surgery. Personalized rib cartilage ear framework fabrication was determined by the measurements. Results: Among the 73 cases, 58 cases received auricular reconstruction successfully. There were 15 patients whose rib cartilages did not meet the requirements and postponed the surgery. The patients who underwent auricular reconstruction were followed up for 6 to 12 months (average, 9 months). During the follow-up, 52 cases had satisfactory outcomes in size, shape, symmetry and details. No deformation of reconstructed ears or chest wall was found during the follow-up. Conclusions The 1∶1 2D printing based on CT scanning is a simple and timesaving way to evaluate the rib cartilage. It can be beneficial to save the amount of cartilage and improve the personalized ear framework fabrication.