Objective To explore the effect of statin in treatment of hypertensive atherosclerotic patients with cerebral infarction and the its effect in prevention cerebral infarction recurrence.Methods 108 hypertension patients with atherosclerotic cerebral infarction were randomly divided into two groups,each group had 54 cases.The control group received conventional treatment;the observation group was given combination therapy with statin and the conventional treatment.The efficacy was evaluated after 2 months.The blood pressure,blood lipid and cerebral function,cerebral infarction recurrence within 1 year after treatment in the two groups were observed.The clinical efficacy of the two groups was compared.Results After treatment,blood pressure,blood lipid indexes and brain function of the observation group were better than those of the control group(all P ＜ 0.05).The total effective rate of the observation group was 100％,which was higher than 76％ in the control group(x2 =9.488,P ＜ 0.05).The control group had 12 cases of recurrence(recurrence rate 22％),1 case recurrence in the observation group(recurrence rate 2％),with no significant difference between two groups (x2 =13.277,P ＜ 0.05).Conclusion The clinical efficacy of statins in the treatment and prevention of hypertension atherosclerotic cerebral infarction is safe and significant,which is worth to use in clinical practice.

Objective: To study the effects of the treatment of burning mouth syndrome with millimeter wave through cave. Methods: Sixty four patients with burning mouth syndrome were divided into 2 treatment groups of millimeter wave and seal of tongue nerve. Before and after treatment the burning scope of the patients was recorded and analysed statistically. Results: The burning scope in the patients treated with millimeter wave decreased significantly compared that in those with the seal of tongue nerve ( P

Objective To optimize the technological conditions of polysaccharide extraction from Elaeagnus angustifolia L. by enzymatic-assisted ultrasonic. Methods The effects of different enzymes, enzymolysis temperature, enzyme dosage, enzymolysis time, material-water ratio, crushing degree, ultrasonic time and ultrasonic temperature on the extraction rate of Elaeagnus angustifolia L. polysaccharide was analyzed. Results The optimal technological condition was as follows:1.5% cellulase, 1.5% pectic enzyme, enzymolysis time 40 min, enzymolysis temperature 55 ℃, ultrasonic time 25 min, ultrasonic power 400 W, material- water ratio 1∶30, and temperature 60 ℃. In these conditions, the extraction efficiency of polysaccharide was 12.35%. Conclusion The process is simple and practicable, and can be used for the extraction of Elaeagnus angustifolia L. polysaccharide.

ratio of solid and liquid. Conclusion The best extracting condition was that ultrasonic time of 20 min,temperature of 45 ℃ ,ratio of solid and liquid of 1∶10,and extracting 3 times.

Objective To study the optimum flavonoids extraction process of Elaeagnusangustifolia L. with ethanol. Methods The best condition of extraction process of flavonoids was investigated by orthogonal design. Results The ratio of extraction on this condition was 2.295 mg/g. Conclusion The optimum technological conditions attained by theorthogonal experiment was as follows:concentration of ethanol 70%, extraction temperature 45 ℃, extraction time 30 min and the ratio of Elaeagnusangustifolia L. to extractant 1∶16.

Objective To investigate the age-related change of secretory leukocyte protease inhibitor (SLPI) content in stimulated whole saliva. Methods Ninety-four healthy adults aged 20-94 yrs were enrolled. Samples of whole stimulated saliva were collected from all subjects, the SLPI content was analyzed by enzyme-linked immunosorbent assay (ELISA). Results The flow rate of the SLPI in older groups was lower than in the young group (P0. 05) , but the contents of SLPI secretion per time-unit of the three older groups[(2. 12?1. 70), (2. 17?2. 65) , (1. 91?2. 51) ng/min, all P

Objective:To determine the effectiveness of the interve ntion of burning mouth syndrome(BMS) reported by Chinese articles and to assess the quality of the studies by evidence-based medicine. Methods: relevant literatures were searched and identified in Chinese Medical Bio logical Database (CMB) and Chinese Technological Periodical Database (VIP) . Stu dies were selected with following criteria: study design- randomized controlle d trials; participants-patients with BMS. An evidence-based analysis was perfo rmed to the literatures. Results: There were totally 47 articles examined and only 11 of them met the criteria . Meta analysis was not possible due to the low quantity and poor quality, However, as far as the p ublished articles concerned, Lusunjing capsule showed good short-term effect in the treatment and nerve block with vitamin B 1 and B 12 was more effec tive than oral admenistering of vitamin. Conclusion: Th e quantity and quality of the reviewed studies are far from satisfaction and ca n not meet the clinical needs. Further trials of high methodological quality ne ed to be undertaken in order to develop effective treatment of BMS.

.7%and 88.6%.Conclusion IDUS after ERCP yields higher diagnostic accuracy for complex biliary and pancreatic diseases and it is also more dependable in differentiating benign tissues from malignant ones than ERCP alones

Objective To explore the effect of cellular inhibitor of apoptosis protein1 (cIAP-1) gene on the radiosensitivity of SMMC-7721 cells.Methods We silenced cIAP-1 expressions by the shRNA technology,and then we detected the changes of cell proliferation,cell cycle and cell apoptosis by CCK8 as-say,Western blot,qRT-PCR and flow cytometry after the radiotherapy.Results The cell proliferation rate of liver cancer SMMC-7721 cells at different radiation doses of 1 Gy,4 Gy,7 Gy and 10 Gy was detected.Comparing with control group (pGCsi-H1-control),the cell proliferation in cIAP-1 silencing group (pGCsiH1-shRNA) was significantly reduced at various radiation doses,and the effect was dose-dependent (P ＜ 0.05).G1/G0 phase arrest was observed after radiation (P ＜0.01),and the proportion of cells in S phase was significantly reduced compared with control (P ＜ 0.01).Compared with control group,G1/G0 phase arrest was detected (P ＜ 0.05),and the percentage of cell apoptosis was increased significantly in cIAP-1 silencing group (P ＜ 0.05).Conclusion cIAP-1 silencing can enhance the radiosensitivity of liver cancer cells,and inhibit cell proliferation by promoting the anti-tumor effect of radiation.

Objective To explore the role of computer-based simulators in upper gastrointestinal endoscopy training.Methods Forty-one graduate students,residents and GI fellows for further cducation with no experience in endoscopy were randomly assigned to two groups and underwent one-month training with or without a 10-hour computer-based simulator.Each trainee performed upper endoscopy in 20 patients.Comparison was made between the two groups in terms of these performance parameters:esophageal intubation,retroflexion,pyloric intubation,intubation of the descending part of the duodenum and procedure time.Resuits There Was no significant difference in esophageal intubation(P=0.699)and intubation of the second part of the duodenum(P=0.141)between two groups.While the differences were significant in retroflexion (P<0.001),pyloric intubation(P<0.001)and procedure time(P=0.032),i.e.,the simulator group was much better in performance than the other group.Conclusion The computer-bascd simulator is effective in providing trainees with the skills needed for upper gastrointestinal endoscopy,shortening the teaching hours and lessening patients'pain.