Objective To observe the effects of modified Shenmaiyin on arrhythmia in CHD. Methods A total of 180 patients were randomly recruited into a control group (80 cases) and a treatment group (100 cases). Both groups were treated with conventional western medicines. On this basis, the treatment group was treated with modified Shenmaiyin. The conditions of myocardial ischemia and arrhythmia were observed for both groups. Results The total effective rate of ischemia and arrhythmia were 50.00% and 80.00% in the treatment group, constrating to 32.50% and 60.00% in the control group, showing statistical difference (P＜0.05). Conclusion Modified Shenmaiyin had sound effects in improving ischemia and arrhythmia.

This paper described the drafting background,including the process and division of labour,of the general guidelines of clinical trials on new drugs of TCM (hereinafter called the guideline) published by China Food and Drug Administration (CDFA) in 2015.The paper mainly introduced the key content and outstanding characteristics of the guideline.The guideline indicated that purpose and target of the clinical trials on the new drugs of TCM should be in accordance with clinical practice and bring clinical benefits to the patients.Besides,the guideline stipulated that the risk/benefit assessment was requisite before marketing a new drug,emphasizing the importance of adequate exploratory clinical trials,scientificalness of the disignation of the endpoints of clinical efficacy,and the significance of the quality control of clinical trials.The specific requirements for the safety evaluation of the heart,liver and kidney was raised and a request for the preparation of the placebo formulated in the guideline.At the same time,the existing problems and the future development of the guideline are discussed in this paper.

Chronic low back pain is a common type of pain which is related to the dysfunction of low back muscles. In recent years, the pressure biofeedback has been widely used for the assessment and treatment of chronic low back pain. This paper reviewed the reliability and validity of pressure biofeedback unit in the evaluation of lumbar and abdominal muscles activity, as well as its application on the rehabil-itation of chronic low back pain, which mainly related to the assessment and treatment of lumbar muscle activity and lumbar spine stability.

Objective To study the correlation between nontraumatic osteonecrosis of femoral head (NONFH) and ApoA1 polymorphism of blood stasis type.Methods Totally 93 cases of NONFH were selected as the case group, and 83 healthy volunteers were randomly selected as the control group. With TCM constitution questionnaire survey, the case group was screened out 32 cases of blood stasis NONFH type and 61 cases of non blood stasis NONFH type. In the case group and control group, the subjects took blood samples 2 mL, extracted DNA for PCR amplification, PCR products for DNA sequencing. G994T PAF-AH and rs9658282 gene NOS1 site polymorphism were detected for tatistical analysis.Results -75G/A gene AA ApoA1 genotype (OR: 2.578; 95%CI: 1.174-5.663;P=0.018) and A allele (OR: 1.726; 95%CI: 1.121-2.658;P=0.013) may be one of the risk factors of NONFH.Conclusion -75G/A gene ApoA1 may be related to the pathogenesis of NONFH. There was no correlation between the ApoA1 gene polymorphism of -75G/A gene and the pathogenesis of blood stasis NONFH. There was no correlation between the ApoA1 gene polymorphism of +83C/T gene and the pathogenesis of blood stasis NONFH.

Objective To study the relation between alcohol-induced osteonecrosis of femoral head (AIONFH) related with high morbidity TCM constitution type with CYP2C8 gene polymorphisms.Methods Totally 152 Han nationality NONFH cases from Feburary 2014 to September 2015 from outpatient and the inpatient departments in Gansu Province Hospital of TCM were collected. 50 AIONFH cases were set as medical case group; meanwhile, 45 healthy volunteers were enrolled as control group. Database for medical materials of all patients and volunteers was established. TCM distribution for AIONFH patients was determined. Solution DNA extraction kit was used to extract DNA, and detect the concentration and purity of DNA. The target gene was amplified by PCR and the target gene was amplified by gel electrophoresis. The length of the fragment was confirmed to conduct target gene sequencing. With the results of sequencing and gel electrophoresis, the relation of AIONFH with CYP2C8 gene polymorphism in AIONFH patients with phlegm-dampness syndrome and the control group.ResultsThe CYP2C8 gene loci rs17110453 gene polymorphism was not statistically significant between the two groups (χ2=0.253,P>0.05). There was no significant difference in allele between the two groups (χ2=0.077,P>0.05). The risk of disease in CC genotype was 1.37 times higher than the AA genotype (95%CI: 0.339-5.540), without statistical significance (P>0.05). There was no significant difference in genotype and allele distribution between AIONFH patients with phlegm-dampness and non-phlegm-dampness and the control group (P>0.05).Conclusion CYP2C8 gene loci rs17110453 gene polymorphism A/C mutation has no obvious relation with AIONFH risk. There is no clear relationship between CYP2C8 gene loci rs17110453 gene polymorphism with AIONFH.

Purpose: The globalization of food has increased consumer demand for imported food products. China is attracting attention as one of the major overseas consumer markets for Korean ramen. Nevertheless, further understanding of consumer needs is required to adapt to local market conditions and sustain sales growth. This study addressed this gap by investigating the intrinsic and extrinsic food attributes and local consumer characteristics using a hybrid approach of structural equation modeling and artificial neural network analysis to influence loyalty to Korean ramen. Methods: Two hundred Chinese consumers who participated in the survey had experience in consuming Korean ramen. Data were collected through paper questionnaires. A causality validation model was constructed to screen for factors with an impact on loyalty. The importance of attributes is then further discussed using artificial neural network models. Results: A causality validation model was constructed using structural equations to confirm the significant effects of intrinsic attributes (e.g., noodles), extrinsic attributes (e.g., packaging), food involvement, and income on loyalty. Using these factors as inputs, further analysis through an artificial neural network model showed that food involvement as an intrinsic consumer characteristic was the most critical factor in predicting loyalty to Korean ramen, followed by packaging, noodles, and income. Conclusion These findings revealed the important roles of product attributes and consumer characteristics in predicting loyalty. Therefore, increased attention to food-involved consumer segments, selection of appropriate packaging formats, and meeting consumer product sensory needs and their demand for variety may be more conducive to promoting loyalty to imported foods.

Purpose: The globalization of food has increased consumer demand for imported food products. China is attracting attention as one of the major overseas consumer markets for Korean ramen. Nevertheless, further understanding of consumer needs is required to adapt to local market conditions and sustain sales growth. This study addressed this gap by investigating the intrinsic and extrinsic food attributes and local consumer characteristics using a hybrid approach of structural equation modeling and artificial neural network analysis to influence loyalty to Korean ramen. Methods: Two hundred Chinese consumers who participated in the survey had experience in consuming Korean ramen. Data were collected through paper questionnaires. A causality validation model was constructed to screen for factors with an impact on loyalty. The importance of attributes is then further discussed using artificial neural network models. Results: A causality validation model was constructed using structural equations to confirm the significant effects of intrinsic attributes (e.g., noodles), extrinsic attributes (e.g., packaging), food involvement, and income on loyalty. Using these factors as inputs, further analysis through an artificial neural network model showed that food involvement as an intrinsic consumer characteristic was the most critical factor in predicting loyalty to Korean ramen, followed by packaging, noodles, and income. Conclusion These findings revealed the important roles of product attributes and consumer characteristics in predicting loyalty. Therefore, increased attention to food-involved consumer segments, selection of appropriate packaging formats, and meeting consumer product sensory needs and their demand for variety may be more conducive to promoting loyalty to imported foods.

Purpose: The globalization of food has increased consumer demand for imported food products. China is attracting attention as one of the major overseas consumer markets for Korean ramen. Nevertheless, further understanding of consumer needs is required to adapt to local market conditions and sustain sales growth. This study addressed this gap by investigating the intrinsic and extrinsic food attributes and local consumer characteristics using a hybrid approach of structural equation modeling and artificial neural network analysis to influence loyalty to Korean ramen. Methods: Two hundred Chinese consumers who participated in the survey had experience in consuming Korean ramen. Data were collected through paper questionnaires. A causality validation model was constructed to screen for factors with an impact on loyalty. The importance of attributes is then further discussed using artificial neural network models. Results: A causality validation model was constructed using structural equations to confirm the significant effects of intrinsic attributes (e.g., noodles), extrinsic attributes (e.g., packaging), food involvement, and income on loyalty. Using these factors as inputs, further analysis through an artificial neural network model showed that food involvement as an intrinsic consumer characteristic was the most critical factor in predicting loyalty to Korean ramen, followed by packaging, noodles, and income. Conclusion These findings revealed the important roles of product attributes and consumer characteristics in predicting loyalty. Therefore, increased attention to food-involved consumer segments, selection of appropriate packaging formats, and meeting consumer product sensory needs and their demand for variety may be more conducive to promoting loyalty to imported foods.

Objectives: Online grocery shopping has gained traction with the digital transformation of retail. This study constructs a behavioral model combining values, attitudes, and reasons for behavior—specifically, facilitators and resistance—to provide a more novel discussion and further understand the relative influences of the various factors affecting continuance intention in online grocery shopping. Methods: Data were collected through an online questionnaire from consumers who had engaged in online grocery shopping during the past month in Seoul, Korea. All collected data were analyzed using descriptive analysis, and model validation was performed using partial least squares structural equation modeling. Results: Continuance intention is primarily driven by facilitative factors (compatibility, relative advantage, and ubiquity). Attitude can also positively influence continuance intention. Although resistance factors (price, tradition, and risk) do not significantly affect continuance intention, they negatively affect attitude. Values significantly influence consumers’ reasoning processes but not their attitude. Conclusions These findings explain the key influences on consumers’ online grocery shopping behavior in Seoul and provide additional discussion and literature on consumer behavior and market management. To expand the online grocery market, consumers should be made aware of the potential benefits of the online channel; the barriers they encounter should be reduced. This will help sustain online grocery shopping behavior. Furthermore, its positive impact on attitude will further strengthen consumers’ continuance intention.

Retrospective multi-center study on medical records of Uyghur medicine diagnosis and treatment program of eczema was done. Demography, diagnostics, therapeutics, efficacy evaluation and nursing data and other information were collated and analyzed. With analysis and summary of the primary and the secondary symptoms, eczema was divided into four types:blood corruption type (Ofunetlengen Kan Tiplik), blue colored yellow bile type (Zenggereng Sapra Tiplik), abnormal black bile type (Hayri Tabii Savda Hilitlik), and salty phlegm type (Shor Belgem Hilitlik). Uyghur Medicine syndrome differentiation and efficacy evaluation criteria were established. Skin itching, lesion shape, and lesion area integral of patients were scored before and after the treatment, respectively. According to the improvement in symptoms of Uyghur medicine syndrome and life quality of patients, and the internal environment change, evaluation criteria for the efficacy of disease symptom combination were established. On this basis, in accordance with the technical requirements of the national new medicine assessment technology, the study developed clinical research guidelines for the treatment of eczema with new Uyghur medicine.