Cytoskeleton-associated protein 2(CKAP2)gene is located on human chromosome 13q14.3 and encodes cytoskeleton associated protein 2,which is involved in regulating the separation of mitotic chromosomes.CKAP2 has been confirmed in multiple studies to be an oncogenic gene that can regulate JAK2/STAT3,FAK-ERK2,and NF-κB signaling pathway affects the biological behaviors of tumor cells such as proliferation,apoptosis,and inva-sion,alters the tumor microenvironment,and regulates tumor immunity.CKAP2 is also closely related to the forma-tion of spindle bodies during mitosis,and dysregulation of CKAP2 can lead to incorrect chromosome separation,promoting tumor development.In addition,CKAP2 is closely related to chemotherapy resistance in tumors,and the underlying mechanisms are not yet clear.CKAP2 may become a novel tumor marker and effective therapeutic target,playing an important role in the diagnosis and treatment of tumors.