Objective:To explore the rules of Professor Zhang Binghou’s experience on treating insomnia. Methods:The formula for insomnia treated by Professor Zhang Binghou in Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University and Beijing Tongrentang Hospital of Traditional Chinese Medicine from Oct. 1, 2016 to July 31, 2019 were collected and sorted out. By establishing the database of formulasto analyze their frequency, patterns, association rules, core medicines and combination of new formulas by cluster analysis by using Traditional Chinese Medicine Inheritance Support System (TCMISS) software V2.5. Results:Among 83 formulas, there were three main types of TCM syndromes, which were the heart-kidney disjunction, heart spleen deficiency and liver-kidney yin deficiency, and involving 134 Chinese herbs. The high frequently ones were Ziziphi Spinosae Semen, Platycladi Semen, Margaritifera concha, and Mauritia arabica. Forty core Chinese herbs combination. Forty herbal combinations with high frenquency and 12 new formulas were identified. The top 5 herbal combinations with high frenquency were Platycladi Semen- Ziziphi Spinosae Semen, Ziziphi Spinosae Semen- Margaritifera concha, Platycladi Semen- Margaritifera concha, Platycladi Semen- Ziziphi Spinosae Semen- Margaritifera concha and Platycladi Semen- Mauritia arabica. The combined formulas were Cannabis fructus- Paeoniae radix alba- Ophiopogonis radix- Atractylodis macrocephalae rhizoma (baked), Scutellariae radix- Asini corii colla- Margaritifera concha- cinnamomi cortex- Platycladi semen, Glycyrrhizae radix et rhizoma praeparata cum melle- Paeoniae radix alba- Atractylodis macrocephalae rhizome (baked)- Coptidis rhizoma- Glycyrrhizae radix et rhizoma praeparata cum melle- Rehmanniae radix- Coptidis rhizoma, Atractylodis macrocephalae rhizome (baked)- Astragali radix praeparata cum melle and Ginseng radix et rhizoma- Pogostemonis herba- Clematidis armandii Caulis- Nelumbinis semen. Conclusions:Professor Zhang's treatment of insomnia mainly focusing on tranquilizing mind, combined with nourishing yin and relieving the internal heat, communicating heart and kidney, invigorating spleen and nourishing heart, nourishing qi and blood based on syndrome differentiation.

Objective To evaluate the clinical effects of the treatment on chronic kidney disease 3 with dampness-heat type. Methods A retrospective cohort study recruited 103 patients with qi deficiency and dampness-heat type of CKD3. Among them,51 cases in the control group were treated with western medicine therapy. The 52 cases in the treatment group received Qingbudigui Decoction. SCr ,eGFR and 24hU-Prowere were observed after 12 months and 24 months for evaluating the clinical effects of Qingbudigui Decoction. Results After 12 and 24 months treatment,the treatment group had a significantly lower SCr and U-Pro(P < 0.01),but a higher eGFR (P<0.01,P<0.05). After 12 months and 24 months,there was no significant change in SCr,U-Pro or eGFR in the control group (P > 0.05). Conclusions Combination therapy of the Qingbudigui Decoction of the patients with qi deficiency and dampness-heat type of CKD3 could delay the kidney disease,which is superior to simple western medicine group. The mechanism may be related to the reduction of urinary protein excretion.

Humans ; Severe Acute Respiratory Syndrome ; diagnosis ; therapy