OBJECTIVE To study the improvement effects of arbutin on myocardial fibrosis （MF） model rats and its mechanism. METHODS The network pharmacology was used to predict the potential target of arbutin in improving MF and molecular docking was used to validated. Totally 50 SD rats were given isoprenaline subcutaneously （5 mg/kg， once a day， for 14 consecutive days） to induce the MF model. Modeled rats were randomly divided into model group， captopril group （9 mg/kg）， arbutin low-dose， medium-dose and high-dose groups （50， 100， 200 mg/kg）， with 10 rats in each group. Another 10 healthy rats were included as normal group. Each group was given the corresponding drugs， once a day， for 28 consecutive days. Twenty-four hours after the final administration， electrocardiograms and heart-related indexes [heart weight index （HWI）， left ventricular weight index （LVWI）] of rats were detected； the levels of creatine kinase （CK）， lactate dehydrogenase （LDH）， N-terminal pro-brain natriuretic peptide （NT-proBNP） and type Ⅰ collagen （Col Ⅰ） and Col Ⅲ were detected in myocardial tissue of rats； the pathological changes of myocardial tissue were observed， and protein and mRNA expressions of adenosine deaminase （ADA） and adenosine kinase （ADK） were detected in the myocardial tissue of rats. RESULTS The results of network pharmacology showed that the main targets of arbutin improving MF were ADA and ADK. The results of molecular docking showed that arbutin bind stably with ADA and ADK. The results of experimental verification showed that compared with model group， the amplitude of ST and T waves in electrocardiogram were improved in administration groups， and the symptoms of atrial flutter were alleviated； HWI （except for arbutin medium-dose group）， LVWI， the levels of CK， LDH， NT-proBNP， Col Ⅰ and Col Ⅲ in the myocardial tissue of rats were decreased significantly （P＜0.05）； the degree of myocardial fibrosis in rats decreased； protein and mRNA expressions of ADA and ADK in the myocardial tissue were significantly increased （P＜0.05）. CONCLUSIONS Arbutin can improve cardiac fibrosis and cardiac function of MF model rats， the mechanism of which may be associated with up-regulating protein and mRNA expressions of ADA and ADK，influencing the nucleotide metabolism and collagen generation. zhangminghao@hactcm.edu.cn

【Objective】 To explore the mediating role of eating disorders in the relationship between body image satisfaction and anxiety symptoms among college students, and further examine the moderating effect of mindfulness on this mediating pathway. 【Methods】 By using convenience sampling, we conducted baseline and follow-up surveys among freshmen and sophomores at two universities in Xizang Autonomous Region from September to December 2021. Measurements included the Generalized Anxiety Disorder Scale, the body image satisfaction subscale of the Multidimensional Body-Self Relations Questionnaire, the Eating Attitudes Test, and the Mindful Attention Awareness Scale. Data analyses performed using SPSS 23.0 included Pearson correlation analysis, mediation (model 4), and moderation (model 58) effect analysis. 【Results】 A total of 2 993 students participated in both the baseline and follow-up surveys, including 1 007 males (34.3%) and 1,666 Tibetan and other ethnic minorities (56.8%), with an average age of 19.8 (SD=1.3) years. Body image satisfaction significantly predicted anxiety symptoms, and this relationship was partially mediated by disordered eating. The presence of mindfulness moderated the impact of body image satisfaction on disordered eating and the influence of disordered eating on anxiety symptoms, indicating varying strengths of these relationships at different levels of mindfulness. 【Conclusion】 This study demonstrates that body image satisfaction can significantly predict anxiety symptoms, with disordered eating playing a mediating role in this relationship. The moderating effect of mindfulness further reveals that students with high levels of mindfulness are less likely to experience eating disorders influenced by body image dissatisfaction. Interventions for college students’ mental health should consider including management of body image and eating behaviors, as well as mindfulness training.