The paper describes the connotation of a hospitals leaping development, presents the significance of such development, and puts forward several relationships that must be properly handled in order for a hospital to achieve leaping development. These include: ①the relationship between priorities and generalities; ②the relationship between objective possibility and subjective initiative; ③the relationship between ardor and soberness; ④the relationship between innovation and convention; ⑤the relationship between speed and quality; ⑥the relationship between the future and the present; ⑦the relationship between academic leaders and the building of the academic echelon; ⑧the relationship between the construction of the management contingent and the construction of the technical contingent; ⑨the relationship between scale and actual strength; ⑩the relationship between hardware and software; B11the relationship between change and stability; and B12the relationship between leaders and the masses.

Acetyltransferases ; genetics ; Breast Neoplasms ; genetics ; Female ; GPI-Linked Proteins ; Gene Expression Regulation, Neoplastic ; genetics ; Humans ; Membrane Glycoproteins ; genetics ; Neoplasm Metastasis ; genetics ; physiopathology ; S100 Proteins ; genetics ; Transcription Factors ; genetics

Objective:To describe the application of intraoral di st raction osteogenesis for correction of maxillofacial and mandibular deformities . Methods: 5 cases with serious maxillofacial or mandibula r deformities underwent distraction by using 2 types of intraoral distraction d evice.Mandibular lengthening and maxillary widening for micrognathia and maxilla ty constriction was performed in 1 case with Treacher Collions syndromes. M axillary distraction osteogenesis for maxillary hypoplasia in 2 cases.Simultaneo us maxillary and mandibular distraction in 1 case with hemifacial microsomia. T ransport distraction for mandibular body rectangle defect in 1 case. Results: Satisfactory morphologic results were achieved in all patients with good facial symmetry, ad equate occlusal relationship without any complication.Conclusions: Intraoral distraction osteogenesis provides a safe and effective treatment for the reconstruction of facial morphologic and occlusal relationshi p.

Objective:To study the ultrastructural characters and mineral content of the newly formed bone induced by distraction osteogenesis(DO) in the canine mandibular defects.Methods:4 beagle canines were used to establish 2.0 cm segmental mandibular defect surgically. Intraoral bifocal distraction osteogenesis was used to repaire the defects. After a 10-day latency, the transport disc was advanced at a rate of 0.5 mm? 2/day until the bone fragment was docked at the planned position. Specimen retrieval at 35 weeks after completion of distraction, scanning electron microscopy(SEM) analysis was then performed. The mineral content was measured by electron dispersive spectroscopy.Results:35 weeks after application of DO the mandibular defects were completely filled with regenerated bone. The regenerated bone was compact, sturdy and mature. The new bone was closed to the transport disk. The Ca/P content ratio was 1.80 in the regenerated bone and 2.02 in the transport disk.Conclusion: DO may induce new bone formation and may be used to repaire mandibular defects.

Objective:To explore the roentgenographic and biomechanical characters of distraction osteogenesis(DO) in the treatment of mandibular defect.Methods:4 beagle dogs were used to establish 2.0 cm mandibular defect model,after 6 months, a 1.5 cm transport disc was surgically created adjacent to the defect area in an intraoral way, and intraoral device was placed on the transport disc and the base bone segments.A reconstructive plate was applied to stabilize the bone segments. After a 10 day latency period, the transport disc was advanced at a rate of 0.5 mm ? 2/day until the bone fragments were docked at the planned position.35 weeks after completion of distraction the animals were sacrificed,specimen retrieval,roentgenography and the stress testing were performed.Results:The regenerated segments were comparable with the corresponding segments of native mandible,and exact location of junction between the regerated and preexisting bone could not be determined easily. Roentgenographic revealed that the defects were reconstructed with outer cortical layer and trabecular medullary cavity of the bone.The regenerated segments remained less radiodense than the native mandible.Stress test demonstrated that the average ultimate strength of regenerated segmens was (69.4?19.2) MPa,that of the corresponding normal mandible was (86.9?31.9) MPa,and that of junction between transport disc and base bone was(46.9?8.4) MPa. Conclusion:Intraoral distraction osteogenesis may be feasible in the treatment of mandibular defect.

Objective To observe the effects of sodium arsenite (NaAsO2) on the expression of transcription factor nrf2 (Nrf2) and heme oxygenase 1 (HO-1) in Chang liver cells, and to explore the possible mechanism by using buthionine sulfoximine ( BSO), a GSH synthesis inhibitor. Methods Chang liver cells were treated with NaAsO2 at the doses of 5, 10 and 20 ?mol/L, alone, for 24 h, or pretreated with BSO (3 mmol/L, 12 h). Western blot assays were used to detect the protein expression of Nrf2 and HO-1. Results The protein expression of Nrf2 and HO-1 significantly increased in 5, 10 and 20 ?mol/L of NaAsO2 alone groups, and Nrf2 and HO-1 protein expression was up-regulated even higher by BSO pretreatment (P

Objective To explore the psychological behavior features between different sexual children with oppositional defiant disorder(ODD).Methods The subjects were sampled from grade 1 to 5 in a primary school in Ji-nan,Shandong Province.According to the diagnosed criteria,42 pupils were diagnosed ODD,which was the study group,and 556 pupils without ODD became the control group.The pupils and their families were investigated and as-sessed by using Achenbach Child Behavior Checklist (CBCL).Results According to CBCL,there was extremely sig-nificantly higher score of depression,obsessive -compulsive,hyperactive,aggressive,interpersonal behaviors in ODD boys [(5.00 ±3.73)scores,(4.88 ±3.65)scores,(5.21 ±3.49)scores,(1 0.1 0 ±6.85)scores,(2.88 ±1 .99) scores]than those in healthy control group [(1 .65 ±2.61 )scores,(1 .91 ±2.65)scores,(2.46 ±2.63)scores, (3.95 ±4.52)scores,(1 .34 ±1 .61 )scores](t =4.31 ,3.90,4.76,4.33,4.40;P =0.000,0.000,0.001 ,0.000, 0.000).There was significantly higher score of symptoms of somatization,indiscipline,schizoid -like behaviors in ODD boys with [(2.38 ±2.50)scores,(2.63 ±2.70)scores,(3.1 7 ±2.35)scores]than those in healthy control group [(0.85 ±1 .63)scores,(0.1 3 ±1 .76)scores,(1 .51 ±1 .72)scores](t =2.94,2.85,3.37;P =0.007,0.009, 0.002).There was extremely significantly higher score of depression,communication disorder behaviors in ODD girls [(5.44 ±4.1 2)scores,(3.1 1 ±2.93)scores]than those in healthy control group with [(2.50 ±3.34)scores, (1 .36 ±2.08)scores](t =3.57,3.38;P =0.000,0.001 ).A significantly higher score of hyperactive,aggression, cruelty behaviors in ODD girls [(4.67 ±4.41 )scores,(9.33 ±7.82)scores,(1 .1 7 ±1 .79)scores]than those in healthy control group [(1 .87 ±2.38)scores,(3.1 9 ±4.08)scores,(0.24 ±0.66)scores](t =2.67,3.30,2.1 8;P =0.01 6,0.004,0.043).Conclusions According to CBCL,there were more psychological behavior problems in ODD children than healthy children.A significantly higher difference was found in different gender.

?Objective:To analyze the therapeutic characteristic of mandibular prognathism by means of orthognathic surgery and orthodontic treatment.Methods:125 patients with skeletal mandibular prognathism were treated by intraoral ramus osteotomy or mandibular body osteotomy,They also accepted different preoperative and postoperative orthodoitic treatment according to different surgery.Results: Satisfied results were obtained through combined treatment of orthognathic surgery and orthodontics.The effective rate of intraoral ramus and mandibular body osteotomy was 88.3% and 83.3% respectively .Two patints treated with mandibular body osteotomy relapsed in two years,and mandibular body osteotomy was performed again to correct the diformity.Conclusion:proper pre and postoperative orthodontic treatments are necessary in order to assure asethetics effect and ideal occlusion in new position.

Objective: To investigate the influence of repeated infiltrating on the microstucture of In-Ceram alumina substrate. Methods:6 disks of aluminum oxide with the height of 3 mm and diameter of 12 mm were perpared and infiltrated with infiltrating glass for 0～5 times for each disk respectively.The fractured surfaces of the samples were observed by scanning elctron microscope. Results:After sintering,a net -shaped porous coping of alumina was formed. The glass infiltration resulted in a dense ceramic mass. The porous coping matrix was infiltrated with low-viscosity glass in void.3-time-infiltration resulted in the best results. Conclusion: With repeated infiltrating firing,the micro-stucture of In-Ceram alumina substrate may become a dense mass.

Ginseng is a typical adaptogen which has resistance to various stresses. This effect is related to the hypothalamic-pituitary-adrenal (HPA) axis. As the main active ingredients, saponin has the similar structure to steroids. The regulation characteristics of ginseng saponin on the HPA axis are narrated from the aspects of total saponin and saponin monomers in this paper after the introduction of adaptation definition and HPA axis regulation mechanisms. Pharmacological effects of ginseng saponin and the regulation effect of HPA axis are summarized finally.