p9O ribosomal S6 kinases(BSKs)are overexpressed in 50% human breast cancer. RSKs enhance the proliferation of breast cancer cells by regulating several key breast cancer-related proteins. They also improve survival of the breast cancer cells through regulating translocation and translation of mRNA. In addition. RSK promotes tumor angiogenesis by interaction with estrogen receptor. However, RSK4 may play an inhibitory role in breast cancer. In general, except RSK4,RSKs may become promising targets of breast cancer therapy.

Objective: To explore influence of abnormal glucose metabolism on vascular endothelial injury in patients with essential hypertension (EH). Methods: A total of 46 pure EH patients (EH group) and 33 EH patients complicated type 2 diabetes mellitus (T2DM, EH + T2DM group) were enrolled. Blood glucose, blood lipid, body mass index (BMI), serum concentrations of homocysteine (Hcy) and urine microalbumin were measured and compared between two groups. Relationship among serum Hcy, urine microalbumin concentrations and blood glucose, blood lipids, BMI were analyzed. Results: Compared with EH group, there were significant increase in levels of BMI, fasting blood glucose (FBG), 2h postprandial blood glucose (2hPBG), glycosylated hemoglobin (HbA1c), triglyceride (TG), low density lipoprotein-cholesterol (LDL-C) and apolipoprotein B (ApoB), (P<0.05 or <0.01), and even more significant increase in serum levels of Hcy [(12.78±2.51) μmol/L vs. (16.26±2.91) μmol/L] and urine microalbumin [(19.45±5.24) mg/L vs. (33.65±10.70) mg/L] in EH + T2DM group, P<0.01 both; Pearson correlation analysis indicated that in EH patients with DM, serum Hcy level was positively correlated with BMI, FBG, HbA1c, LDL-C, ApoB and urine microalbumin (r=0.667~0.906，P<0.01 all), while urine microalbumin level was positively correlated with BMI, HbA1c, LDL-C, ApoB and serum Hcy (r=0.566~0.685, P<0.01 all). Conclusion: Abnormal glucose metabolism can aggravate both vascular endothelial injury and renal microvascular injury in patients with essential hypertension, and these are closely related with degree of abnormal glucose metabolism. Therefore, controlling blood glucose level can relieve vascular injury, further relieve pathological development of cardiovascular diseases as well as renal complications.

Objective: To explore the influence of impaired glucose metabolism (IGM) on cardiovascular function in patients with essential hypertension (EH). Methods: A total of 46 pure EH patients and 36 EH + type 2 diabetes mellitus (T2DM) patients were selected. Levels of blood glucose, blood lipids, serum uric acid (UA), fibrinogen (Fb), serum homocysteine (Hcy) and urinary microalbumin were measured, and patients received 24h ambulatory blood pressure monitoring (ABPM) and color Doppler echocardiography. Clinic indexes, ambulatory blood pressure parameters and incidence rate of cardiac diastolic dysfunction were compared and analyzed between two groups. Cardiac diastolic dysfunction was regarded as a binary dependent variable, and it underwent multi-factor gradual binary regression analysis. Results: Body mass index (BMI), blood glucose, blood lipids (except high density lipoprotein cholesterol, apoprotein AI), UA, Fb, serum Hcy and urinary microalbumin levels in EH + T2DM group were significantly higher than those of pure EH group (P<0.05 or P<0.01), and their 24h mean systolic blood pressure (24hSBP), daytime mean SBP (dSBP), 24h mean pulse pressure (24hPP) and daytime mean PP (dPP) were significantly higher than those of pure EH patients (P<0.05 or P<0.01). Left ventricular ejection fraction (LVEF) of both groups was > 40%, and incidence rate of cardiac diastolic dysfunction in EH + T2DM group (72.2%) was significantly higher than that of pure EH group (45.7%), P<0.05. Binary Logistic regression analysis indicated that age (OR=1.160, 95%CI: 1.002~1.342, P=0.012), DM (OR=3.095, 95%CI: 1.056~9.079, P=0.029) and glycosylated hemoglobin (HbA1c, OR=1.756, 95%CI: 1.261~2.445, P=0.008) were independent risk factors for cardiac diastolic dysfunction in EH patients. Conclusion: Impaired glucose metabolism aggravates cardiovascular system dysfunction in patients with essential hypertension through aggravating atherosclerosis and cardiac early diastolic dysfunction. Therefore, improvement of glucose metabolism in these patients could help to reduce their risk of cardiovascular diseases.

Some experiments indicated that there is J-shape relationship among morbidity and mortality of cardiovas-cular diseases and salt intake.Its main causes are:(1)methods of measuring sodium intake are not the same;(2) The sensitive for individual is also not the same;(3)There are influence of other dietury factors related cardiovas-cular disease.This article reviews related discuss.

Animals ; Dependovirus ; genetics ; immunology ; Gene Transfer Techniques ; instrumentation ; Genetic Therapy ; instrumentation ; Genetic Vectors ; genetics ; immunology ; Humans

Eight mongrel dogs were involved in the investigation of sevoflurane effects on renal blood flow (RBF). After intravenous anesthesia and surgical preparation, RBF, MAP, HR, CVP, CO and SV were recorded as baseline. Sevoflurane was then administered to achieve end-tidal concentrations of 1, 2, 3 and 4% in succession. Following 20 mins equilibration at each concentration, and 30 mins after the termination of inhalation, the above parameters were measured repeatly for comparing. Results showed significant dose-related depressions of RBF, MAP, HR and CO with sevoflurane. RBF didn't reduce significantly until MAP decreased to 9.3kPa, with end-tidal concentration of sevoflurane no less than 3%, it didn't recover in step with improved hemodynamic parameters after sevoflurane withdrawal. This study indicates that sevoflurane may influence little on autoregulation of RBF, its dose-related cardiac depression may be responsible for the reduction of RBF.

Based on the scheme and classification system of International Classification of Functioning, Disability and Health-Children and Youth Version (ICF-CY), the motor dysfunction of cerebral palsy children mainly involved body structure and function, including skele-tal development, joint, function of muscle and nerve reflex, and the systemic movement disorder. A hydrotherapy intervene scheme was rec-ommended based on dysfunction under ICF-CY framework.

Diabetic vascular complications are the key cause of the poor life quality and high mortality in diabetic patient. Advanced glycation end products (AGEs) and its cross-links play important roles in the diabetic vascular complications. Endothelial cells damage induced by AGEs may account for the initial agent for diabetic vascular complications. Recent studies have shown that AGEs inhibitors and breakers can prevent and reverse these complications. This article reviewed the research progress of AGEs and endothelium dysfunction. The potential therapeutic method was also stated.

Objective To evaluate the function of regulatory T (Treg)cells in peripheral blood from patients with psoriasis, and to explore the possible role of the STAT3 signaling pathway in Treg cell dysfunction. Methods Totally, 81 patients with psoriasis vulgaris, who all presented with chronic plaques and had a psoriasis area and severity index (PASI)score of 10 - 30, were enrolled into this study. Forty-six healthy blood donors served as the control group. Venous blood samples were collected from these subjects followed by isolation of Treg cells and responder T (Tresp)cells. Flow cytometry was performed to determine the proportion of Treg cells in peripheral blood as well as that of cells secreting phosphorylated-STAT3(p-STAT3), interferon γ(IFN-γ), tumor necrosis factor α(TNF-α)and interleukin 17(IL-17)in Treg cells, and quantitative real-time PCR (qRT-PCR)to measure the expression levels of IFN-γ, TNF-α and IL-17 mRNAs in Treg cells. Some Treg cells and Tresp cells were cultured in vitro alone or in combination, and flow cytometry was conducted to estimate cellular proliferative activity on day 7 after stimulation with IL-2. Some patient-derived Treg cells were classified into several groups to be cultured alone or in combination with Tresp cells with or without the presence of the STAT3 pathway inhibitor, Stattic V (10 or 50 μg/L), for 7 days. Subsequently, flow cytometry was performed to evaluate the proliferative activity of Tresp cells, and qRT-PCR to measure the expression levels of IFN-γ, TNF-α and IL-17 mRNAs in Treg cells. Results No significant differences were observed in the proportion of Treg cells in peripheral blood between the patient group and control group (6.437% ± 0.186% vs. 6.812% ± 0.241%, t = 1.224, P >0.05). Compared with control-derived Treg cells, the patient-derived Treg cells showed significantly decreased proliferative activity and inhibitory effects on Tresp cells, but increased proportion of cells secreting p-STAT3, IFN-γ, TNF-α and IL-17 (all P < 0.05). After the treatment with 50 μg/L Stattic V, a significant increase was observed in the inhibitory effect of patient-derived Treg cells on Tresp cells (inhibition rate: 61.670% ± 4.640% vs. 28.820% ± 11.490%, P < 0.05), but a significant decrease in the mRNA expressions of IFN-γ (2-△△C t: 1.654 ± 0.879 vs. 23.350 ± 6.721, P <0.05), TNF-α(0.850 ± 0.705 vs. 4.847 ± 1.525, P < 0.05)and IL-17(0.572 ± 0.135 vs. 3.095 ± 0.650, all P < 0.05)in patient-derived Treg cells compared with untreated patient-derived Treg cells. Conclusions The negative regulatory effect of Treg cells on Tresp cells is decreased in patients with psoriasis, which may be associated with abnormal activation of the STAT3 signaling pathway, and inhibition of the pathway may restore the function of Treg cells to a certain extent.

Objective:To assess clinical efficacy of micro-punch combined with electron beam radiation for the treatment of keloids on the lower jaw.Methods:Clinical data were collected from 36 patients with keloids on the lower jaw, who received micro-punch combined with electron beam radiation at Department of Dermatology, Xijing Hospital, the Fourth Military Medical University from January 2018 to January 2019, and analyzed retrospectively. There were 16 males and 20 females, with an average age of 23.80 years and a median disease duration of 32 months. The severity of keloids was evaluated before and 12 months after operation. A paired t test was used to compare keloid severity scores before and after treatment. Results:All of the 36 patients experienced primary wound healing. The keloid severity score was 7.11 ± 1.46 before operation, and significantly decreased to 2.33 ± 0.47 at 12 months after operation ( t=13.85, P=0.008) . Twelve months after the treatment, 15 patients were cured, 17 showed marked improvement, and 4 showed no response or experienced recurrence within 12 months after treatment, with a response rate of 88.89%. Conclusion:Micro-punch combined with electron beam radiation is effective for the treatment of keloids on the lower jaw.