Objective To investigate the diagnostic value of the real-time four-dimensional ultrasound imaging examination in the diagnosis of fetal malformations.Methods Four-dimensional ultrasound prenatal audio and video materials,1 008 cases of 12～20 weeks pregnant were retrospectively analyzed,and the dignostic value for the fetal malformation Was obser red by following-up.Results Four-dimensional ultrasound detection of fetal malformations in 26 cases,27 cases of confirmed postpartum fetal malformations,the rate was 96.3%,1 case of missed diagnosis.missed diagnosis rate was 3.7%misdiagnosis rate was 0.Conclusion The dynamic continuous four-dimensional ultrasound could show the activities of the fetus in uterus,diagnosis of most of the morphological structure of fetal malformations,reduced birth defects in children.

Molecular targeted agents for small cell lung cancer have been introduced in great many clinical trials in recent years. The classes of targeted agents include antiangiogenic agents,growth factor receptor inhibitors,Bcl-2 inhibitors,SCR kinase inb.ibitors, recombinant molecules N-901 and inhibitors of the sonic hedgehog signaling pathway. The class of antiangiogenic agents,including bevacizumab and thalidomide,is be-ing evaluated in phase Ⅱ and Ⅲ trials. The tyrosine and Scr kinase inhibitors are being evaluated in phase Ⅰ and Ⅱ trials. The recombinant molecule, N-901 is undergoing phase Ⅱ testing in patients with relapsed small cell lung cancer. The other pathways undergoing evaluation for the development of pharmacologic agents include inhibiturs of bcl-2 and sonic hedgehog signaling,which are being tested in the earliest phases of clinical evalua-tion. Primary data shows small cell lung cancer is not sensitive to targeted therapy and further studies are re-quested.

The breast cancer stem cells are a subpopulatiom of breast tumor cells that selectively possess tumor initiation and self-renewal capacity. Recent findings suggest that it may correlate with the failure treatment and relapse of breast cancer. The isolation of phenotypically distinct tumorigenic of breast cancers will find a way to elucidation of the pathways that account for their tumorigenic potential to cure the disease.

Ischemia-reperfusion after neonatal asphyxia is a key factor in renal injury,which often leads to apoptosis of tubular epithelial cells.Apoptosis is an important form of injury for renal tubular epithelial cells after asphyxia.Smac/DIABLO is released to the cytosol in response to diverse apoptotic stimuli while mitochondrial targeting signal peptide is removed.In the cytosol,Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins,thus allowing the activation of caspases and apoptosis.And thus it increases the ischemia-reperfusion renal injury,leading to acute renal failure.

Dental Pulp Cavity ; anatomy & histology ; diagnostic imaging ; Humans ; Radiography ; Root Canal Therapy ; methods

Objective To study the possible protective effect of low dose whole body γ-irradia-tion on dopaminergic neuron. Methods In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-in-duced injury mice model,the levels of dopamine (DA) and its metabolites in striata of mice were detec-ted by igh performance liquid chromatogram (HPLC), and neurons (dopaminergic neuron, activated gitter cell and horizontal cell) were counted by immunohistochemical staining after low dose whole body irradiation. Results 3.5 Gy irradiation significantly restored the levels of DA and its metabolites decreased by MPTP. Conclnsion Low dose whole-body γ-irradiation does offer neuroproteetion againstMPTP- mediated damage of striatal dopaminergic nerve fibers.

Bone Plates ; Bone Screws ; Fracture Fixation, Internal ; Humans ; Maxillofacial Injuries ; surgery ; Oral Surgical Procedures ; Terminology as Topic

Xigu is an important term and concept in the theory of acupuncture and moxibustion. In this paper, textual research is performed to trace the original meaning of the Inner Canon of Yellow Emperor; and by referencing medical experts' annotation and research in the history, the interpretation and annotation of Xigu is conducted. Besides, the relationship between Xigu and acupoint is discussed and emphasized. Hence, this paper could provide reference for acupoint theoretical research and clinical practice of acupuncture.
Acupuncture Points ; Acupuncture Therapy ; history ; China ; History, Ancient ; Humans ; Medicine in Literature

Acupuncture Points ; Adolescent ; Adult ; Child ; Combined Modality Therapy ; Electroacupuncture ; Exercise Therapy ; Female ; Humans ; Male ; Middle Aged ; Patella ; injuries ; Rheumatic Diseases ; therapy ; Young Adult

Brain ; physiopathology ; Female ; Foot ; anatomy & histology ; physiopathology ; Humans ; Meridians