1.Hereditary hyperhomocysteinemia: a case report.
Li GUO ; Bing-xiao LI ; Yuan-zong SONG
Chinese Journal of Pediatrics 2010;48(7):547-548
Child
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Humans
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Hyperhomocysteinemia
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genetics
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Male
2.Urodynamic study of bladder dysfunction after radical resection of rectal carcinoma
Jiye ZHAO ; Debin ZONG ; Bing TIAN ; Xiaodong JING ; Meng LI ; Yong LI ; Nan WANG
Chinese Journal of Postgraduates of Medicine 2013;(2):1-3
Objective To investigate the diagnosis and treatment of bladder dysfunction after radical resection of rectal carcinoma.Methods One hundred and sixty-five patients with bladder dysfunction after radical resection of rectal carcinoma were observed by urodynamic study.The results included maximum urinary flow rate,postvoid residual,urine volume,pressure of detrusor,maximum urethral closure pressure.These patients were treated by different methods.Results Bladder with underactive detrusor were 116 patients,109 patients returned to normal voiding after 3 months,7 patients were performed with suprapubic cystostomy.Detrusor overactivity were 42 patients,insufficiency of urethral sphincter were 7 patients,all symptoms of them improved after treatment.Conclusion Patients with bladder dysfunction after radical resection of rectal carcinoma should do check to clear etiology,according to the results to take the appropriate means to treatment.
3.Study of lumbar spinal stability after laminectomy in the treatment of lumbar intraspinal tumors
Taihang GAO ; Shaohui ZONG ; Bing LI ; Ran ZHANG ; Shuzhen LI ; Yuan YANG ; Kun YANG
Journal of Medical Postgraduates 2014;(9):949-951
Objective Laminectomy is destructive to bone structure in spine , which affect spinal stability .This article was to investigate the effect on spinal stability after laminectomy in different segments of vertebral plate in the treatment of lumbar intraspinal tumors. Methods Retrospective analysis were made on the data of 143 patients with lumbar intraspinal tumors from January 2009 to June 2012 in 6 hospitals.All the patients underwent laminectomy with no use of inner regular apparatus during the operation .JOA evalu-ation was applied to observe short-term efficacy , while ASIA scale for long-term efficacy .Comparison was made on lumbar spinal stability before operation and in the last visiting . Results From the observation of short-term efficacy, JOA evaluation score rised from (1.12 ± 0.65)to (1.97 ±0.71).Form the observation of long-term efficacy, ASIA scale classification was as follows:4 cases of Grade I, 6 cases of Grade II, 14 cases of Grade III, 53 cases of Grade IV and 66 cases of Grade V.In the following 12-30 months′visiting, all patients were covered.In the last postoperative visiting, patients suffering spinal instability after laminectomy were as follows:2 of 45(one seg-ment), 9 of 47(two segments), 5 of 27 (three segments) and 2 of 14 (four segments).From the observation on the postoperative spinal sta-bility and the segments in laminectomy , spinal stability of one-segment group was significantly higher than that of multi-segment group ( P=0.047).No significant difference exist between the groups of less than 2 segments and more than 3 segments as well as the groups of less than 3 segments and more than 4 segments. Conclusion A single seg-ment laminectomy on lumbar intraspinal tumors showed good postopera-tive spinal stability .But laminectomy in two or more segments implied greater risk of postoperative spinal instability .
5.Antimicrobial Peptides: Antibacterial Mechanism and Therapeutic Use
Xiao-Shu HOU ; Zong-Li HU ; Guo-Ping CHEN ; Yong LI ; Bing-Qin WANG ; Zhi-En LI ;
Microbiology 1992;0(01):-
Antimicrobial peptides, a cluster of small peptides secreted by the majority of creatures, have been demonstrated with activity against a wide range of microorganisms including bacteria, protozoa, yeast, fungi, viruses and even tumor cells. These peptides have some features such as broad spectrum , high effi-cacy and stability, little drug resistance. A lack of new antibiotics combined with emerging multi-drug resis-tance issues demands that new antimicrobial strategies be explored for treating these infections. It has been proposed that the antimicrobial peptides might form the foundation for a new class of clinically useful an-timicrobials. We review the advantages of these molecules in construction features and bioactivity, with the focus on the mechanism and clinical applications.
6.Immunotherapy of metastatic renal cell carcinoma: report of 28 cases.
Hui-jun WANG ; Hai WANG ; Han-zhong LI ; Bing-bing SHI ; Zong-lu SONG
Chinese Journal of Surgery 2004;42(4):205-206
OBJECTIVETo determine the efficacy of IL-2, IFN and Furtulon in patients with metastatic renal cell carcinoma.
METHODSDuring the induction phase of the treatment of 28 patients, which lasted 3 months, IL-2 and IFN were administered subcutaneously three times a week at doses of 5 - 20 MU/m(2) and 6 - 9 MU/m(2), Furtulon was administered at doses of 800 - 1,200 mg daily by oral during 28 days a month.
RESULTSThe response rate was 46.4%, including 4 complete response (CR), 9 presented with partial response (PR).
CONCLUSIONThe three-drugs combination described in this study demonstrates activity. Based on the present data, combined biochemotherapy may be a promising new approach to the therapy of the metastatic renal cell carcinoma.
Administration, Oral ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Carcinoma, Renal Cell ; therapy ; Combined Modality Therapy ; Drug Therapy, Combination ; Female ; Floxuridine ; administration & dosage ; Humans ; Immunotherapy ; Injections, Subcutaneous ; Interferons ; administration & dosage ; Interleukin-2 ; administration & dosage ; Kidney Neoplasms ; therapy ; Male ; Middle Aged ; Neoplasm Metastasis ; Treatment Outcome
7.An experimental study on the prevention of enteral bacterial translocation in scalded rats by smectite powder.
Hai-tao SU ; Yi-shu LI ; Shu-liang LU ; Man SUN ; Chun QING ; Zong-yu LI ; Tie-bing SHAO ; Li-bing HUANG ; Bing QU ; Xin-bo YANG
Chinese Journal of Burns 2005;21(2):89-92
OBJECTIVETo explore the preventive and treatment effects of smectite powder on enteral bacterial translocation in scalded rats.
METHODSFifty-four Sprague-Dawley (SD) rats were randomly divided into three groups, i.e. normal control (A, n = 6), burn control (B, n = 24), and burn treatment (T, n = 24) groups. The rats in B and T groups were fed with tracing bacteria JM109, which was transfected with PUC19 plasmid in advance. The rats were subjected to 30% TBSA scald injury after the plasmid was shown to have colonized in the intestine. Smectite powder (0.6 g/day/kg) was fed to rats of T group immediately after the scalding, while those in B group received no smectite powder. Bacterial translocation in blood and mesenteric lymph nodes in all groups was observed and identified by enzyme digestion at 12 post scald hour (PSH) and on 1, 3 and 5 post-scald days (PSD). The contents of malondialdehyde (MDA) and superoxide dismutase (SOD) were determined in rat intestinal tissue. And the degree of injury to the entire small intestine was observed pathologically. The villus height of intestinal mucosa was measured, and the rate of epithelial nuclear splitting of mucosal crypts was calculated.
RESULTSThe number of rats with positive blood bacterial culture in B group was obviously higher than that in A and T groups (P < 0.05) on 1 and 5 PSD. The bacterial quantity in mesenteric lymph nodes (MLN) in T group on 1 PSD (38 +/- 16 CFU/g) and 5 PSD (68 +/- 20 CFU/g) were obviously lower than those in B group (228 +/- 67 vs 183 +/- 29 CFU/g, P < 0.05). There was significant difference in the intestinal contents of MDA and SOD between B and T groups at each time point (P < 0.05). The rat jejunum villus height and the epithelial nuclear splitting in the small intestine mucosa in T group were evidently higher than those in B group (P < 0.05 or 0.01).
CONCLUSIONSmectite powder is beneficial to the protection of the intestinal mucosa in scalded rats, and can effectively prevent postburn intestinal bacterial translocation in rats.
Animals ; Bacterial Translocation ; Burns ; drug therapy ; microbiology ; Intestinal Mucosa ; microbiology ; pathology ; Rats ; Rats, Sprague-Dawley ; Silicates ; therapeutic use
8.Efficient and rapid liquid reduction animal model.
Bing HAN ; Shu-ming KOU ; Biao CHEN ; Yao-zong PENG ; Yue WANG ; Yu-long HAN ; Xiao-li YE ; Xue-gang LI
China Journal of Chinese Materia Medica 2015;40(22):4446-4451
To investigate the practicability of establishing zebrafish lipid-lowering drug screening model and the effect of berberine (BBR) on hyperlipidemic zebrafish. Three-month-old zebrafishes were fed with 4% cholesterol for 0, 2, 4, 8, 14, 20, 25, 30 days, and the level of total cholesterol in serum was measured. Zebrafish were randomly divided into four groups: the control group, the high cholesterol diet group, the 0.01% simvastatin-treated group, the 0.1% berberine-treated group and the 0.2% berberine-treated group. The levels of total cholesterol (TC), triglyceride (TC), low density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) in serum were measured; the expression of hepatic HMGCR, LDLR and CYP7A1a mRNA expressions were detected by real time PCR. Oil red O staining was performed to observe the changes in fat content in the liver. According to the result, the level of serum TC in the 4% cholesterol diet group significantly was higher than that of the normal control group in a time-dependent manner and reached a stable level at the 20th day. The BBR group showed significant decreases in the levels of TC, TG and LDL-c, HMGCR mRNA expression and fat content and increases in LDLR and CYP7A1a mRNA. The hyperlipidemia zebrafish model was successfully established by feeding with 4% cholesterol for 20 days. The findings lay a foundation for further screenings on lipid-lowering drugs.
Animals
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Berberine
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administration & dosage
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Cholesterol
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metabolism
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Disease Models, Animal
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Drugs, Chinese Herbal
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administration & dosage
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Female
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Humans
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Hyperlipidemias
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drug therapy
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metabolism
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Hypolipidemic Agents
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administration & dosage
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Liver
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drug effects
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metabolism
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Male
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Triglycerides
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metabolism
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Zebrafish
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metabolism
9.Effect of vacuum assisted closure on collagenase activity in human chronic wound.
Bing SHI ; Ping ZHANG ; Wang-zhou LI ; Shao-zong CHEN ; Jin-qing LI
Chinese Journal of Plastic Surgery 2006;22(6):465-467
OBJECTIVETo study the variations of collagenase activity in exudates of human chronic wound before and after treatment of VAC so as to partly disclose the mechanisms of VAC in promoting chronic wound healing.
METHODSThe exudates of acute wounds (postoperative breast cancer) were postoperatively collected at day 1, 2, 3, and in 6 chronic wounds (4 cases of venous ulcer, 2 cases of pressure sore) the exudates were also collected before and 2, 4, 6 days after the treatment with VAC. The type-III collagen degradation from the exudates was checked with zymography timepoint. The types of the collagenase in exudates were evaluated by using doxycycline inhibition.
RESULTSDrainage fluids from acute wound might degrade type-III collagen partly with no changes at day 1, 2, 3. There were high collagenase activities in chronic wound exudates. Exudates from patients before treatment with VAC can degrade type-III collagen completely. But collagenase activities became less and less after VAC. Doxycycline inhibition tests indicated that it can't inhibit the activity of collagenase at 100 micromol/L concentration, until it reached 600 micromol/L.
CONCLUSIONSCollagenase activity is elevated in chronic wounds. VAC may be lower the collagenase activity, prevent collagen from degrading abundantly and promote wound healing. Collagenase is mainly MMP-1 type (fibroblast-type) in chronic wound exudates.
Adult ; Aged ; Chronic Disease ; Collagenases ; metabolism ; Female ; Humans ; Male ; Middle Aged ; Negative-Pressure Wound Therapy ; Pressure ; Treatment Outcome ; Wound Healing ; Wounds and Injuries ; surgery
10.500 cases of external ultrasound-assisted liposuction.
Bing SHI ; Wang-zhou LI ; Xue-yong LI ; Shao-zong CHEN
Chinese Journal of Plastic Surgery 2004;20(2):86-89
OBJECTIVETo discuss the therapeutic effects and safety of external ultrasound-assisted liposuction and to find out the rules of circumference variation in different body areas after liposuction.
METHODSExternal ultrasound liposuction was performed on 500 patients (595 sites). We recorded the volume of anesthetic drugs and the aspirated pure fat as well as the body contour variations of every area at one to three months postoperatively. The decreased dimension at different body sites after liposuction were compared and analyzed.
RESULTSThe volumes of the anesthetic liquid and the aspirated pure fat were the most in the waist-abdomen and the thigh. After liposuction, the circumstances in different body areas were all decreased to certain degrees. Along with the severity of obesity, changes in the waist-abdomen became more obvious and the decreases of the umbilical circumference, the minimum and the maximum waist circumferences were prone to be less. But when the, minimum waist circumference was over 111 cm, obvious changes occurred in the umbilical. Meanwhile, the upper-middle part of the thigh and the upper arm showed larger variations than the lower part. The ultrasound-assisted liposuction had less blood loss and pain. It resulted in smooth skin without severe complications.
CONCLUSIONSExternal ultrasound-assisted liposuction is a safe, effective and easily acceptable operation for body contour remodeling. The body circumference variation may have its intrinsic rule, which, to some extent, is meaningful for conducting clinical inquiry and forecasting the operation results.
Abdomen ; surgery ; Adipose Tissue ; surgery ; Adolescent ; Adult ; Aged ; Female ; Forearm ; surgery ; Hip ; surgery ; Humans ; Leg ; surgery ; Lipectomy ; instrumentation ; methods ; Male ; Middle Aged ; Treatment Outcome ; Ultrasonics