Objective To evaluate the role of early postoperative enteral immunonutrition on host nutritional status,immune and inflammatory responses.Methods Ninety six patients with gastric cancer were randomized to receive either an immune enhancing enteral diet or an isocaloric,isonitrogenous control diet for 7 days.Enteral feeding was initiated 24 hours after surgery.Host immunity was evaluated by IgG、IgM、IgA、CD4、CD8、CD4/CD8,and inflammatory response was reflected by IL-1?、IL-2、IL-6、IL-10、TNF-?.Total protein,albumin,prealbumin,transferring and nitrogen balance were determined as nutritional indicators.Results After the study,prealbumin,IgA,CD4,and CD4/CD8 levels were significantly higher in study group than in control group.IL-6,TNF-?concentrations were significantly lower in study group than in control group.Conclusions Postoperative administration of immunonutrtion in patients with gastric cancer can positively modulate postoperative immunosuppressive and inflammatory responses.

0.05).Postoperative plasma proteins were also decreased after the operation,and patients in TPN group decreased more obviously,the differences between the two groups were statistically significant(P0.05),but wound healing was better in TEN group than TPN group(P

The larval and adult schistosomes can effectively establish the stable parasitic relationship with their final hosts and then maintain the parasitism for a long time,due to the successful adaptation to their parasitic lifestyle. This paper reviews the progress of research on parasitic adaptability of schistosomes in several respects,and demonstrates the application value of schisto-somal genes related to parasitic adaptability in schistosomiasis control and exploitation of natural active molecules.

Carcinoma, Hepatocellular ; surgery ; Catheter Ablation ; Humans ; Liver Neoplasms ; surgery

Objective To identify the sex-related DNA copy number alterations (CNA) in hepatocellular carcinoma (HCC). Methods High-resolution array comparative genomic hybridization Carray- CGH) was used to examine 17 female and 46 male HCCs. Two-tailed Fisher's exact test or χ2 test was used to compare the differences in CNA between females and males. Results The overall frequencies and patterns of CNA in female and male cases were similar. However, female HCC tumors presented more copy number gains compared to male on lq21. 3-q22(76. 5% vs 37. 0%, P = 0. 009), llqll(35. 3% vs 0. 0%, P = 0. 000 2) and 19ql3. 31-ql3. 32(23. 5% vs 0. 0%, P = 0. 004), and more loss on 16pll. 2(35. 3% vs 6. 5%, P = 0. 009). Relative to females, male cases had more copy number loss on llqll(63. 0% vs 17. 6%, P = 0. 002). Further analyses showed that llqll gain was correlated with 19ql3. 31-ql3. 32 gain(P = 0. 042) and 16pll. 2 loss(P = 0. 033), while lq21. 3-q22 gain was correlated with 19ql3. 31-ql3. 32 gain(P = 0. 046). Conclusion Our findings suggest that CNA may play an important role in sex-related difference in HCC development.

Cells, Cultured ; Flutamide ; pharmacology ; Human Umbilical Vein Endothelial Cells ; cytology ; drug effects ; metabolism ; Humans ; Proto-Oncogene Proteins c-myb ; metabolism ; Sp1 Transcription Factor ; metabolism ; Testosterone ; antagonists & inhibitors ; physiology ; Transcription Factors ; metabolism ; Tumor Suppressor Protein p53 ; metabolism

Objective: To investigate the interaction between ciprofloxacin (CIP) and ferric-ion binding protein (FBP) from pathogenic bacteria, so as to determine whether FBP is the target of CIP. Methods: Reactions between ciprofloxacin and FBP from N. gonorrhoeae, which was expressed in E. coli, were monitored by UV-visible and NMR spectroscopy. Results: Fe3+ was removed from holo-FBP by CIP in 10 mmol/L Tris-Cl buffer, pH 7.40, at 298 K, and half of the loaded Fe3+ was taken off when 50 molar equivalence of CIP was present. Conclusion: CIP can remove Fe3+ from holo-FBP, indicating that CIP can interfere with the Fe3+ capture of the bacteria and influence the growth and virulence of the bacteria.

Bufalin is one of the major active components of Chan Su,a traditional Chinese medicine.Studies at home and abroad have confirmed that bufalin can inhibit cell proliferation significantly in many human leukemia and solid cancer cell lines by inhibiting endothelial hyperplasia and angiogenesis,and inducing cell differentiation and apoptosis. With the deepening of study,it is showed that bufalin has extensive anticancer activities and it has potential clinical value with very low drug concentration.

Objective To investigate effects of laparoscopic repair of abdominal wall incisional hernia using polypropylene and expanded polytetrafluoroethylene(e-PTFE) composite mesh. Methods Forty-one patients with abdominal wall incisional hernia(4~25 cm in length and 3~18 cm in width) were treated in this hospital from October 2004 to August 2005. The patients received laparoscopic mesh herniorrhaphy after complete dissection of adhesion using an ultrasonic scalpel.A polypropylene and(e-PTFE) composite mesh(Bard Composite Mesh) was used and fixed using the Ethicon Endopath Multifeed Stapler(EMS).Results The laparoscopic mesh herniorrhaphy was successfully completed in all the 41 patients without conversions to open surgery.The operative time was 60~182 min(mean,85 min).Postoperatively,the patients felt slight pain and began to take food on the second day.The time to first passing flatus was 25~41 hours(mean,32 hours).The postoperative hospital stay was 5~7 days(mean,6 days).No recurrence occurred during a follow-up period of 6~16 months(mean,9 months) in the 41 patients. Conclusions The laparoscopic incisional hernia repair using the Bard Composite Mesh is a safe and effective method.

Objective To investigate the clinical effects of laparoscopic repair of esophageal hiatal hernia using Bard CruraSoft PTFE/ePTFE Mesh combined with Toupet partial fundoplication.Methods From August 2006 to April 2007,13 patients with esophageal hiatal hernia(typeⅠin 6 and type Ⅲ in 7)were treated by laparoscopy in our hospital.Under a laparoscope,esophageal hiatal hernia was separated by ultrasonic scalpel,and then repaired using Bard CruraSoft PTFE/ePTFE Mesh with Ethicon Endopath Multifieed Stapler.Afterwards,Toupet partial fundoplication was performed.Results The operation was completed in all the cases without converting to open surgery.The mean operation time was 142 min(115-185 min);mean intraoperative blood loss was 75 ml(25-120 ml);mean time to the first flatus and oral feeding was 32 h(26-37 h);and mean postoperative hospital stay was 4 d(3-6 d).The patients were followed up for 4-11 mon(mean 6.5 mon).The symptoms disappeared in 1 month.Three months after the operation,barium examination found no recurrence of the hernia in the 13 cases.Conclusions Laparoscopic repair of esophageal hiatal hernia with mesh combined with Toupet partial fundoplication is a safe and minimally invasive operation.The method is worth being widely used.