11? Hydroxysterold dehydrogenases (11?-HSDs )catalyse the interconversion of active glucocorticoids(cortisol,corticosterone )and their inert 11?-keto derivatives(cortisone,11-dehydrocorticosterone)They play an important role in regulating the local glucocorticoids activities.Glucoeorticoids can induce insulin resistance.The alteration of 11?-HSD activities in tissues such as liver ,adipose tissue, is closely relevant to some common disorders,including obesity and type 2diabetes mellitus.

BACKGROUND:There are usualy removable appliances and fixed appliances in the mouth of orthodontic patients, resulting in periodontitis. Because of its high security, good heat resistance, long action time, not easy to produce resistance and wide antimicrobial spectrum, inorganic antibacterial agents have become a research hotspot. OBJECTIVE:To review the application and research progress of inorganic nano-antibacterial materials in orthodontic treatment. METHODS:A computer-based search of PubMed and CNKI databases was performed for articles about applications of inorganic nano-antibacterial materials in orthodontic treatment published from January 2001 to December 2014 using the keywords of “orthodontic, antibacterial agent” in English and Chinese, respectively. RESULTS AND CONCLUSION:Inorganic nano-antibacterial materials for oral bacteria have good antibacterial properties, and are a kind of ideal biological material. Bracket enamel adhesive, removable appliance resin material and bracket can play correct and antibacterial roles by modification of inorganic nano-antibacterial materials, so as to reduce complications such as dental caries. However, the application of nano-antibacterial materials is stil in its infancy, the modified materials need to be studied further in terms of color problems, physical and chemical properties and biological security.

Objective:To explore the relationship among biochemical indexes and ECG features in patients with unsta‐ble angina pectoris (UAP) .Methods:A total of 130 UAP patients treated in our hospital from Jan 2014 to Jun 2014 were selected .According to presence of inverted T wave or not ,patients were divided into normal T wave group (n =53) and inverted T wave group (n=77);according to presence of elevated ST segment or not ,patients were di‐vided into normal ST segment group (n=66) and ST elevation group (n=64) .Levels of C reactive protein (CRP) , white blood cell count (WBC) ,cardiac troponin T (cTnT) ,creatine kinase isoenzyme MB (CK-MB) ,low density lipoprotein cholesterol (LDL‐C) ,blood uric acid (UA) and TIMI score were compared among all groups .Results:Compared with normal T wave group ,there were significant rise in levels of CRP [ (5.34 ± 1.02) mg/L vs .(9.79 ± 3.18) mg/L] ,WBC [ (8.42 ± 3.19) 109/L vs .(10.34 ± 2.46) 109/L] ,cTnT [ (0.11 ± 0.02)μg/L vs .(0.21 ± 0.04)μg/L] ,blood UA [ (3.98 ± 0.57)μmol/L vs .(4.72 ± 0.86)μmol/L] ,LDL‐C [ (321.52 ± 12.79) mmol/L vs .(357.83 ± 12.14) mmol/L] and TIMI score [ (2.66 ± 1.62) scores vs .(4.58 ± 2.31) scores] in inverted T wave group , P<0.01 all;compared with normal ST segment group ,there were significant rise in levels of CRP [ (6.38 ± 1.77) mg/L vs .(9.75 ± 2.56) mg/L] ,WBC [ (7.59 ± 2.08) 109/L vs .(9.43 ± 2.74) 109/L] ,cTnT [ (0.14 ± 0.03)μg/L vs .(0.23 ± 0.05) μg/L] ,blood UA [ (3.54 ± 0.52) μmol/L vs .(4.71 ± 0.76) μmol/L] ,LDL‐C [ (341.05 ± 12.01) mmol/L vs .(369.23 ± 11.57) mmol/L] and TIMI score [(2.78 ± 1.58) scores vs .(3.92 ± 2.14) scores] in ST elevation group , P<0.01 all .Conclusion:Inverted T wave and ST elevation on ECG are related to status of UAP .Evaluation of patient′s ECG can provide evidence for treatment .

Objective To investigate the clinical and skeletal muscular pathological features of chronic progressive external ophthalmoplegia(CPEO).Methods The clinical and skeletal muscular pathological data of 6 patients with CPEO were analyzed retrospectively.Results All of the 6 patients onset were 4 to 18 years old.The first symptom was blepharoptosis.The clinical mainly manifestations were limited activity of eyeball,accompanied with limbs muscle fatigue,weakness and level elevatation of serum creatine kinase(CK).5 cases had myogenic changes in electromyography(EMG).The skeletal muscular pathological examination showed that the ragged red fibers(RRF)were scattered among the muscle fibers,and the deficient or absent of COX activity in many fibers.A few degenerating and necrotic fibers were observed in 4 cases.Lipid-drops were increased by oil red "O" stain in 3 cases.Electromicroscope showed that abnormal mitochondria increased in number and aggregated under sarcolemma or in cytoplasm.Crystalloid inclusion body could be observed.Conclusions The clinical mainly features of CPEO are external ophthalmoplegia and accompanied with limbs weakness.RRF and COX activity deficiency or absence according to skeletal muscle pathology can be suggest and support the diagnosis of CPEO.Gene sequencing based on skeletal muscle biopsy is necessary to make the final diagnosis of CPEO.

Gene Library ; Humans ; Nucleic Acid Hybridization ; methods ; Pulmonary Fibrosis ; diagnosis

Asthma ; diagnosis ; Child ; Humans ; Perception

Objective To evaluate the reliability and validity of Diabetes Diet-Related Quality-of-Life Scale (DDR-QOL) in Chinese version,in order to provide an efficient instrument for assessing the quality of life of diabetes in diet therapy.Methods Translating and edit the DDR-QOL scale initially,275 eligible subjects were invited to the study.DDR-QOL scale and 36 item Short Form Health Survey (SF-36) were used to collect data which were conducted for evaluating the internal consistency,reproducibility,construct validity,convergent and discriminant validity of DDR-QOL.Results The total Cronbach's α was 0.86.The factor analysis suggested good construct validity of DDR-QOL.Significant correlations were found between DDR-QOL and SF-36.The quality of life of diabetes who is on the job or not can be identified by DDR-QOL.Conclusions The Chinese version of DDR-QOL is a valid and reliable tool to assess the quality of life of diabetes who are in diet therapy.

Medical therapy,education and scientific research are three functions of a hospital,in which education is one of the core tasks.The author thinks that we should strengthen the cultivation of the teachers;raise the level of the managements;increase the teaching input and reinforce the reform of education and scientific research so as to drive and improve the development of the hospital.

Purpose:To investigate fMRI and DTI in the assessment of cortical visual impairment in children with periventricular leukom-alacia ( PVL).Materials and Methods: Twenty-four children with PVL were enrolled.Meanwhile,24 age-matched normal controls were recruited for comparison.fMRI scan was performed using a 3.0T MR scanner.Data analysis was performed by statistical parametric mapping software (SPM2).Activated voxels were identified in both groups,t test was used for statistical analysis.DTI was performed by MedlNRIA software and DTI color maps were created from fractional anisotropy (FA) values and the three vector elements,FA values on diffusion tensor color maps were compared between the patients and the controls.AH the FA values of these WM fibers were analyzed by paired t test.The correlation was calculated between FA values and activated voxels of visual cortex for PVL children using SPSS10.0.Results: In all 24 normal children,the maximum response of blood oxygen level-dependent (BOLD) signal was located in the primary visual cortex ( PVC).However,some of the 24 cases of PVL had deviated activation.The active voxels of patients in visual cortex were less than that of controls.All 24 cases of PVL showed a significant mean FA reduction in ICPL and PTR in comparison to the ipsilateral regions of healthy controls.The significantly positive correlation was shown between FA values and activated voxels of visual cortex for PVL children.Conclusion:fMRI and DTI play an important role in the assessment of cortical visual impairment in children with PVL.

AIM: To observe the clinical effect of the tonifying kidney pills with mingmuwuzi treating evaporative dry eyes.METHODS: This study adopted the positive drug control,prospective study,random number remainder grouping method to 65 cases of outpatient patients diagnosed with evaporative dry eyes which were divided into the treatment group 32 cases (64 eyes) and the control group 33 cases (66 eyes).The treatment group took the decoction of kidney pills with mingmuwuzi,combined with sodium hyaluronate eye drops.The control group simply use sodium hyaluronate eye drops,both group were set to 4wk for a course of treatment.To observe the symptoms and signs of two groups before and after the treatment,the change of the evaluation index and curative effect were evaluated.RESULTS: The effectiveness of the treatment group was 87.5%,the control group was 78.8%,the difference was statistically significant (z=-3.149,P<0.05).CONCLUSION: The treatment of the kidney pills with mingmuwuzi combined with sodium hyaluronate eye drops to evaporative dry eyes is more effective than the simple use of sodium hyaluronate eye drops.