Xigu is an important term and concept in the theory of acupuncture and moxibustion. In this paper, textual research is performed to trace the original meaning of the Inner Canon of Yellow Emperor; and by referencing medical experts' annotation and research in the history, the interpretation and annotation of Xigu is conducted. Besides, the relationship between Xigu and acupoint is discussed and emphasized. Hence, this paper could provide reference for acupoint theoretical research and clinical practice of acupuncture.
Acupuncture Points ; Acupuncture Therapy ; history ; China ; History, Ancient ; Humans ; Medicine in Literature

Objective To study the possible protective effect of low dose whole body γ-irradia-tion on dopaminergic neuron. Methods In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-in-duced injury mice model,the levels of dopamine (DA) and its metabolites in striata of mice were detec-ted by igh performance liquid chromatogram (HPLC), and neurons (dopaminergic neuron, activated gitter cell and horizontal cell) were counted by immunohistochemical staining after low dose whole body irradiation. Results 3.5 Gy irradiation significantly restored the levels of DA and its metabolites decreased by MPTP. Conclnsion Low dose whole-body γ-irradiation does offer neuroproteetion againstMPTP- mediated damage of striatal dopaminergic nerve fibers.

Molecular targeted agents for small cell lung cancer have been introduced in great many clinical trials in recent years. The classes of targeted agents include antiangiogenic agents,growth factor receptor inhibitors,Bcl-2 inhibitors,SCR kinase inb.ibitors, recombinant molecules N-901 and inhibitors of the sonic hedgehog signaling pathway. The class of antiangiogenic agents,including bevacizumab and thalidomide,is be-ing evaluated in phase Ⅱ and Ⅲ trials. The tyrosine and Scr kinase inhibitors are being evaluated in phase Ⅰ and Ⅱ trials. The recombinant molecule, N-901 is undergoing phase Ⅱ testing in patients with relapsed small cell lung cancer. The other pathways undergoing evaluation for the development of pharmacologic agents include inhibiturs of bcl-2 and sonic hedgehog signaling,which are being tested in the earliest phases of clinical evalua-tion. Primary data shows small cell lung cancer is not sensitive to targeted therapy and further studies are re-quested.

Minimally invasive treatment has received increasing attention in the field of tumor therapy. Imaging-guided ablation (phys-ical or chemical) and 125I particle implantation have recently become first-line therapies for malignant tumors. A comparison with com-puted tomography, ultrasound, or digital subtraction angiography (DSA) illustrates that magnetic resonance imaging (MRI) shows ex-treme superiority in both intracranial tumor diagnosis and interventional therapy. Nevertheless, MRI also has a deficiency. This study aims to discuss the value of an MRI-guided minimally invasive treatment in glioma and its metastatic tumor.

Objective To study the expression levels of Bcl-2 and Caspase-3 protein in osteosarcoma,and discuss the role of Bcl-2 and Caspase-3 gene in the occurrence and development of human osteosarcoma,as well the relationship between their expression levels and Ennecking staging.Methods SP immunohistochemical staining assay was applied to detecting the expression levels of Bcl-2 and Caspase-3 protein in 30 aptients with osteosarcoma,and the results were analyzed with SPSS11.0 software.Results The positive rate of Bcl-2 and Caspase-3 protein in osteosarcoma was respectively 73.3% and 86.7%.There were prominent differences of positive rate of Bcl-2 and Caspase-3 between osteosarcoma and osteochondroma groups.The expression rates of Bcl-2 and Caspase-3 protein had no significant difference among osteosarcoma Ennecking grade Ⅰ to grade Ⅲ respectively.In osteosarcoma group,no correlation existed between the expression rates of Bcl-2 and Caspase-3(P＞0.05).Conclusion Although the occurrence and development of human osteosarcoma are correlated with the dropout of apoptosis,they are implicated in a complicated course participated by multiple genes and procedures.Bcl-2 and Caspase-3 gene play a certain role partly.SP immunohistochemical staining assay shows a higher sensitivity in detecting the expression of Bcl-2 and Caspase-3 protein in osteosarcoma;however,their expression levels were not correlative to Ennecking staging.Therefore,the expression of Bcl-2 and Caspase-3 may not be used as the criteria of the malignant degree and prognosis of osteosarcoma.

Objective To explore the optimum treatment of low back pain due to osteoporosis.Methods60 female patients aged 60～86 years with low back pain due to osteoporosis treated from January, 2007 to December, 2009 were investigated.ResultsCompared with spinal radicle block, silver needle combined with dorsal spinal radicle block could treat low back pain due to osteoporosis more effectively and its long term curative effect was obvious.ConclusionSilver needle combined with dorsal spinal radicle block has good analgesic effect on low back pain due to osteoporosis.

According to the records in Neijing (Internal Classic), this article discusses the relationship during the connotative evolution of mai (vessel) and jing (meridian) in the three aspects, named mai (vessels), the evolution from mai (vessel) to jing (meridian), and the connotation replacement of jing (meridian) with mai (vessel). The study results show that the connotation of Jingmai is originated from mai (vessel), but more enriched, which cannot be confused with each other. The recognition on the connotation of jingmai from mai (vessel) to jing (meridian) is the process of TCM understanding from concretization to abstraction, and from the entity to the concept. Jing (meridian) represents the law on the longitudinal and invariable running course of meridian, differenti from the perspective in western medicine in human body. This law results from the naive observation and is based on the rational summary and thinking, and it stands up the approval from practice. The description of jing (meridian) as mai (vessel) is just the superficial description of this term. In fact, its concept infers to the connotation of meridian.
China ; History, Ancient ; Humans ; Medicine in Literature ; Meridians ; Qi ; history

Dust ; Humans ; Pneumoconiosis ; etiology

Objective To investigate the value of three-dimensional color power angio(3D-CPA)in the prenatal diagnosis of pernicious placenta previa (PPP ) with placenta increta.Methods The ultrasonographic findings of PPP with placenta increta diagnosed in our hospital by 2D-CDFI and 3D-CPA were reviewed and compared with pathologic histology examination.For each of the two imaging methods, sensitivity,specificity,positive predictive value and prenatal diagnose accordance rate were summarized. Results For 3D-CPA,sensitivity,specificity and positive predictive value were 91.1%,88.9% and 93.3%, respectively.The results of 3D-CPA were higher than those in 2D-CDFI (sensitivity 76.4%,specificity 66.7%,positive predictive value 81.5% ),and were statistically significant (P <0.05 ).The diagnose accordance rate of 3D-CPA was statistically higher than that of 2D-CDFI (90.4% vs 73.0%;P <0.05). Conclusions 3D-CPA can display abnormal vascular reconstruction between the placenta and uterine wall from various angles,and is more accurate than 2D-CDFI.3D-CPA plays an important role in the prenatal diagnosis of PPP with placenta increta.

Objective Discuss and analyze Staphylococcusaureus in isolation and drug resistance in patients with pediatric re-spiratory infection,providing guidelines for clinical treatment on the control of infection.Approaches collect 5 413 cases of respiratory tract infection from Jan.2013 to Dec.2014 in patients (including pediatrics neonatology)with sputum specimens, applying MicroScan-As4 automated Microbes Identification analyzer to identify and test drug sensitiveness of the separated strains,using Whonet 5.6 for statistical analysis.Results 1 540 strains of 29 different pathogenic bacteria were isolate from pediatric patients with respiratory tract infection,among which there were 336 strains (21.82%,336/1540)of Staphylococ-cus aureus (SAU,S.aureus),more than 1/5 of the total of pathogenic bacteria.And the isolation rate of pediatric respiratory tract infection accounted for 6.2 1%,significantly higher than that of other pathogenic bacteria isolation rate (with the excep-tion of Haemophilus influenzae>5%,the rest all<5%).In all detected SAU,methicillin-resistant Staphylococcus aureus (MRSA)occpied 59 strains (17.56%,59/336),which indicated that SAU played a leading place in patients with pediatric respiratory infection.The antimicrobial drug resistance rate of SAU against vancomycin,Nai thiazoleamine,daptomycin,and Quinupristin was 0,whereas to other antibiotics it showed different degrees of resistance.The drug resistance rate of MRSA to penicillin and ampicillin,oxacillin,ampicillin/sulbactam,amoxicillin/clavulanic acid and cefazolin,ceftriaxone was 100%,to erythromycin,clindamycin over 50%,to other antimicrobial resistance in low resistance.Conclusion There were more SAU in children with respiratory infection;especially MRSA bears multi drug resistance.Therefore,the monitoring of drug resist-ance of Staphylococcus aureus should be strengthened,and antimicrobial drugs should be rationally chosen according to the results of drug sensitive test for individuals,so that resistant strains can be under effective control and kept being reduced from emergence.