Anatomic structures and their relative position of the target and organs at risk surrounded will change more or less during fractional radiotherapy.These uncertainties will affect the practice of treatment planning correctly.The degree of these uncertainties can be investigated by imaging verification system during clinical practice.The possible reasons of these uncertainties may be tumor volume variations,organ motions orshape changes,patients weight or form changes and set-up errors.The development and practice of imageguided radiotherapy,dose guided radiotherapy and adaptive radiotherapy can offer rational approaches to over-come the uncertainties of the target and organ at risk surrounded during radiotherapy.

Objective: From the two prospective of hospital quantity and hospital market shares, to analyze the influences of profitmaking hospital’s competition on medical expenses and medical quality. Methods: The sample of provincial panel data from 2003 to 2011 is used, the fixed effect model is applied. Conclusion: For the competitive effect, the expanding of relative scale of profit-making hospitals increased outpatient expenses and reduced hospitalization expenses; for the quality effectiveness, the expand of relative scale of profit -hospitals improved the quality of outpatient service; the simple increase of the quantity of profit -making hospitals had no significant influences on medical expenses and quality of medical care.

Objective:To develop an HPLC method for the determination of valacyclovir hydrochloride capsules. Methods: An Inertsil ODS (250 mm × 4. 6 mm,5μm) column was employed with methanol-0. 02 mol·L-1 potassium dihydrogen phosphate solution (20∶80) as the mobile phase, the flow rate was 1. 0 ml·min-1, the detection wavelength was at 251 nm, the column temperature was 30℃,and the sample size was 20μl. Results:The linear range of valacyclovir hydrochloride was 2-40μg·ml-1 , the correlation coeffi-cient was 0. 999 9 and the average recovery was 99. 8%(RSD=0. 16%,n=9). Conclusion:The analytical method is simple, accu-rate and special, which can be used in the content determination and quality control of valacyclovir hydrochloride capsules.

Financial departments of hospitals should widen their horizons .Workers responsible for financial affairs should transform their functions and make the transition from the traditional business accountants to the value managers.The idea of macro financeis proposed in this paper to penetrate the financial ideas into every economic and business activity, every element of the workflows and every member of the staff .In practice, fine management of hospitals can be done jointly by using information platforms , employing financial management tools and organizing ef-ficient financial teams .By doing this , both financial management and operation efficiency of hospitals can be im -proved continuously .

This paper reports a cecal hookworm patient whose main symptoms are dry cough,dyspnea and eosinophilia.

Objective: To study the influence of clinicopathologic factors on the recurrent pattern of colorectal cancer after radical treatment. Methods: There were 464 consecutive patients with colorectal cancer treated with radical surgery between January 1998 and December 2002 in our hospital. The clinicopathologic features of 90 patients with relapse of colorectal cancer after radical surgery were analyzed. According to the interval between radical surgery and recurrence, these 90 patients were divided into subgroups, the early recurrent group (within 30 months after surgery) and the late recurrent group (more than 30 months after surgery). Chi-square test was used for univariate analysis, and the Logistic regression model was performed for multivariate analysis. Result: There were 78 (86%) patients in the early recurrent group and 12 (14%) patients in the late recurrent group. The median time of recurrence was 17.4 months. The median recurrent time in stage I patients was 35.1 months, 13.6 months in stage II patients, and 12.9 months in stage III patients, respectively. Univariate analysis showed that the depth of penetration, the number of positive lymph nodes, and the gross appearance of tumor were predictors for early recurrence. Multivariate analysis revealed that the depth of penetration (T category) of the primary tumor significantly predicted for early recurrence (P= 0.049). Conclusion: A great proportion of recurrence in patients with colorectal cancer occurred within 30 months after radical treatment, but the late recurrence which occurs at more than 30 months after radical surgery should not be neglected. Patients with different patterns of recurrence had different intervals between radical surgery and recurrence. DM (distant metastasis) occurs earlier than LR (local recurrence). The depth of penetration of the primary tumor is an independent predictor for early recurrence of colorectal cancer patients after radical surgery.

To get information about the status of use of oral hypoglycaemic agents in an inland and coastal hospitals,the ordes of total cost and DDDs were employed to compare the use of oral hypoglycaemic agents in an inland hospital and a coastal hospital.Our results showed that the much less biguanides were used in the coastal hospital as compared with the inland hospital.It is conclinical practice included dimethyl biguanide,glipizide,gliclazide and glibenclamide.

Objective: To predict the growth trend of total health expenditure in China based on the dynamic relationship between total health expenditure and economic growth. Methods: First, analyze the relationship between total health expenditure and economic growth from 1978 to 2011 with the state space model, evaluate the accuracy of the model and predict total health expenditure range from 2012 to 2016 with the status space mode. Results: Up to 2016, the total health expenditure would reach to 5.681 trillion yuan, and the ratio of the expenditure to gross domestic product(GDP) would increase to 5.692%. Conclusion: It is needed to balance the relationship between total health expenditure and economic growth.

Objective: To describe the non-linear relationship between out-of-pocket ( OOP ) payment and economic growth . Methods: Using logistic smooth transition regression model to analyze the impact of government health expenditure on the non-liner relationship between OOP payment and economic growth. Results:The impact of economic growth on OOP health expenditure is divided into 3 stages:from 1978 to 1996, the influence of economic growth on out-of-pocket payment approaches to highly-efficient mechanism operation;from 1997 to 2008 belongs to the transition period, it stays as low-efficient mechanism operation since 2009. Conclusion: To continue deepening the medical and health system reform and reduce the burden of personal health expenditure.

Objective:To investigate the bone resorption caused by osteoclasts and modulating functions of zinc ion on dental slices.Methods:Osteoclasts were separated from long-limb bones of neonatal rabbits,cultured with de-activated human tooth slices and glass slices.The cells in the experiment group were treated with 1?10~(-14)mol/L-1?10~(-4)mol/L zinc+10%(volume fraction) fetal calf serum(FCS)+?MEM,while those in the control group were grown in 10%FCS+?MEM.Osteoclasts on glass slices were stained by TRAP staining.The absorption pits on tooth slices were observed by inverted phase contrast microscope.The resorbing activity was evaluated with the concentration of calcium in the supernatant liquid of osteoclasts.The ratio between the concentration of calcium in the experiment group and that of the control group was termed the resorption index.Results: The isolated cells were multinuclear and showed positive in cytoplasma by TRAP staining.Usually,osteoclasts resorbed tooth slices first on the cementum and dentin,which had lower content of mineralized tissue.Compared with those on bone slices,the lacunae on the dental slices appeared less in amount,less in area and shallower in depth.They often showed shallow pits in a large area.Microscopy showed that the number and area of absorption pits formed on treated tissues were less than those on the control tissues.The content of calcium in the supernatant liquid increased at the concentrations of 1?10~(-4)-1?10~(-14)mol/L zinc,especially in the group of 1?10~(-8)mol/L,1?10~(-10) mol/L,1?10~(-14)mol/L zinc on the 3~(rd) day(P