Objective:To analyze the relationship between electroencephalogram(EEG)reactivity and early neurological deficits in elderly acute cerebral infarction(ACI)patients with cerebral microbleeds.Methods:Clinical data were collected from 51 elderly ACI patients with cerebral microbleeds admitted to our hospital from July 2018 to April 2020, who formed the ACI with cerebral microbleeds group, and were retrospectively analyzed.The ACI group was composed of 47 patients with ACI treated at our hospital during the same period.All patients underwent EEG examination.EEG reactivity, sleep waves and other signs were monitored.Early neurological deficits were recorded 2 hours after thrombolysis in elderly ACI patients with cerebral microbleeds, assessed using the National Institutes of Health Stroke Scale(NIHSS), and divided into subgroups.Baseline data and EEG-related findings were compared between the two groups.The relationship between the severity of early neurological deficits and EEG reactivity was analyzed.Results:EEG reactivity and the positive detection rate for sleep waves were lower(33.33% or 17/51 vs.65.96% or 31/47, 27.45% or 14/51 vs.61.70% or 29/47, χ2=10.417 and 11.652, P=0.000 and 0.001)and early neurological deficits were more serious( Z=2.381, P=0.017)in the ACI with cerebral microbleeds group than in the ACI group.The proportions of cases with EEG reactivity and negative sleep waves were higher(91.18% or 31/34 vs.8.82% or 3/34, 86.49% or 32/37 vs.13.51% 5/37, χ2=17.771 and 13.147, both P=0.000)and the levels of vWF were lower(6.24±1.79 mg/L vs.13.48±2.23 mg/L, t=12.039, P=0.000)in elderly patients with moderate and severe ACI accompanied by cerebral microbleeds than in elderly patients with mild ACI accompanied by cerebral microbleeds.Logistic regression analysis showed that absence of EEG reactivity( OR=18.994, P=0.000), negative sleep waves( OR=11.520, P=0.001)and low levels of vWF( OR=0.283, P=0.001)were correlated with the degree of early neurological deficits in elderly ACI patients with cerebral microbleeds, with absence of EEG reactivity having the most significant impact.The results of receiver operating characteristic(ROC)curve showed that the area under the ROC curve(AUC)of absent EEG reactivity for predicting early moderate and severe neurological impairment was 0.803(95% CI: 0.650-0.956, P<0.001), indicating a certain degree of predictive value. Conclusions:Elderly ACI patients with cerebral microbleeds are associated with different degrees of functional neurological deficits in early stages, and the degree of neurological deficits may be related to absence of EEG reactivity.In the future, EEG reactivity may be considered as a risk assessment tool for the progression of neurological deficits in elderly ACI patients with cerebral microbleeds.

OBJECTIVE To enhance hospital infection management and ensure medical safety.METHODS To search the accurate orientation,pay attention to coordination,resolve the key problems,strengthen management of key departments,pay a close attention to major issues,bring forth new working methods and explore the management model.RESULTS Once the key link was grasped,everything was feeled in place.The effective methods were summarized.CONCLUSIONS Take the duty to orient accurately,strengthening training and emphasizing the practical results on the breakthrough of hospital infection management method.

PNAS-4 is a novel pro-apoptosis gene identified latetly. In recent years, there has been a large number of research reports on the basic studies about PNAS-4 in cancer gene therapy and gene therapy of PNAS-4 alone or combined with chemotherapy or radiotherapy manifested a good application prospect, but its molecular mechanisms to promote apoptosis is not clear yet. In this paper, recent research about PNAS-4 in cancer gene therapy is briefly reviewed, and recent hypotheses on its molecular mechanisms to promote apoptosis are especially elucidated. Based on its newly identified characteristics of structural domain, we made a point that PNAS-4 might regulate functions of some target protein related to apoptosis by deSumoylation as a new deSumoylating isopeptidase, and consequently promote apoptosis.
Apoptosis ; Apoptosis Regulatory Proteins ; genetics ; Genetic Therapy ; Humans ; Neoplasms ; therapy ; Sumoylation

Objective To explore the expression and significance of TGF-β1 and CTGF in the occurrence and development of patients with subarachnoid hemorrhage. Methods Cerebrospinal fluid TGF-β1 and CTGF concentrations in all subjects were serially detected by ELISA. Results Mean total TGF-β1 and CTGF in patients were elevated more than that in controls at the first day(P＜0.05).Thereafter the levels of TGF-β1 and CTGF fell by the third day, then rose to the second peak at the tenth day and remained significantly increase until the sixteenth day(P＜0.05).The levels of TGF-β1 was positive correlated CTGF. Conclusion The expressions of TGF-β1 and CTGF in patients with subarachnoid hemorrhage showed two peaks character. After SAH, the concentration of TGF-β1 and CTGF concentration is related to chronic communicating hydrocephalus.

Objective To investigate the roles of percutaneous coronary intervention in improving left ventricular function, reducing incidence of cardiovascular events of patients with ischemic cardiomyopathy. Methods Ninety cases of ischemic cardiomyopathy patients from August 2012 to August 2015 were randomly selected, these patients were divided into two groups, the study group (n=45) and control group (n=45) according to the random number table. The control group of patients were given routine treatment, while the study group of patients were given conventional treatment combined with percutaneous coronary intervention. Results The LVEDV, LVEF of the study group were significantly higher (P<0.05), the incidence of acute myocardial infarction onset, hospitalization rates again, mortality rate 8.89% (4/45), 13.33% (6/45), 2.22% (1/45) were significantly lower than the control group 24.44% (11/45), 40.00% (18/45), 17.78% (8/45) (P<0.05) . Conclusion Percutaneous coronary intervention can improve left ventricular function and reduce the incidence of cardiovascular events of patients with ischemic cardiomyopathy.

Objective:To observe therapeutic effect of maleic acid levamlodipine (amlodipine) on inflammatory fac‐tor levels in patients with essential hypertension (EH) .Methods :According to random number table method ,a to‐tal of 84 EH patients were randomly and equally divided into nifedipine group (received nifedipine treatment ) and amlodipine group (received maleic acid levamlodipine treatment ) ,both groups were treated for 12 weeks .Blood pressure ,serum levels of tumor necrosis factor α(TNF‐α) ,interleukin‐6 (IL‐6) and high sensitive C reactive protein (hsCRP) were measured and compared between two groups before and after treatment .Results:Before treatment , there were no significant difference in blood pressure ,serum levels of TNF‐α,IL‐6 and hsCRP between two groups , P>0.05;after treatment ,all above indexes significantly reduced in both groups compared with before treatment ,P<0. 01 all .Compared with nifedipine group ,there were significant reductions in systolic blood pressure [ (136. 9 ± 13.4) mmHg vs . (128.3 ± 12.5) mmHg] ,diastolic blood pressure [ (88.4 ± 7.1) mmHg vs . (82.7 ± 6.8) mm‐Hg] ,serum levels of TNF‐α [ (10.85 ± 2.56) ng/L vs . (8.61 ± 2.37) ng/L] ,IL‐6 [ (18.92 ± 4.61) ng/L vs . (13.73 ± 4.18) ng/L] and hsCRP [ (7.95 ± 2.38) mg/L vs . (5.89 ± 2.24) mg/L] in amlodipine group , P<0.01 all .Conclusion:Amlodipine can more significantly reduce levels of TNF‐α,IL‐6 and hsCRP ,inhibit inflammatory reaction than those of nifedipine and contribute to blood pressure control in patients with essential hypertension .

Objective To investigate the differential diagnosis of early-stage Parkinson disease(PD) and vascular Parkinsonism(VP) by 99Tcm-TRODAT-1 single photon emission computed tomography brain imaging.Methods 99Tcm-TRODAT-1 SPECT brain imaging was performed on 47 patients with early-stage PD,26 with early-stage VP and 30 age-matched healthy control subjects.The radioactive ratio of striatum to cerebullum was calculated by region of interest(ROI) technique.The results were analyzed and compared.Results The distribution and quantities of 99Tcm-TRODAT-1 uptake were reduced in contralateral striatum to clinically symptomatic side of the patients with early-stage PD(P0.05).The radioactive ratio of striatum to cerebullum contralateral to the affected limb in the patients with early-stage PD was lower than that in the healthy control subjects while that to patients with early-stage VP were similar to that in the healthy control subjects.Conclusion 99Tcm-TRODAT-1 single photon emission computed tomography brain imaging and semiquantitative analysis are useful to differentiate VP from PD.

Breast tumor is the most common malignant tumor in female,its incidence is increasing in recent years.With magnetic resonance equipment,image acquisition and processing technology is improved,perfusion imaging studies gradually become the focus of study.The author reviewed MRI perfusion imaging and its application in breast tumors.

Objective To set telephone alarm device in attraction system of automatic control center for timely detection of malfunctions.Methods The vacuum negative pressure meter and the delayed control line were used.The telephone key of H.F.was connected and the dial key was stored.Results Malfunctions could be detected promptly through telephone alarm.Conclusion The attraction system of the center can be examined and repaired in time,thus ensuring the medical security.

[Objective] The better optimization of traditional Chinese medicine for the treatment of respiratory syncytial virus, in the past five years is re-viewed in this paper, also the related domestic experimental research results, and according to the pathogenesis of RSV, it further summarizes the current domestic research for the main direction of the disease. [Methods] The article from the two aspects of compound Chinese medicine and traditional Chinese medicine monomer, according to the pathogenesis of respiratory syncytial virus section, discusses the experiment in vivo and in vitro related rich research results. [Results] It is found by inducing and summarizing, whether individual or compound traditional Chinese medicine, for respiratory syncytial virus re-search has made great achievement, but with experimental study limited to suppress the virus more value-added; replication and inhibiting inflammatory infiltrates the two big aspects, lacking of deeper side of molecular biology research, making the traditional Chinese medicine in the treatment of respiratory syncytial virus research appear too single, not a broader recognition by the industry. [Conclusion] We need to be sure the safety of traditional Chinese medicine for the treatment of respiratory syncytial virus and curative effect, but at the same time must recognize that because of the complexity of its com-position and design of experiment of traditional Chinese medicine, the irrationality of the existence of many factors, it makes progress with many problems, so we must be aware of their own insufficiency, more in-depth explore its mechanism of action, with al kinds of research direction in the future for us.