Many studies have suggested that pathogenesis of asthma could no longer be interpreted merely by “Th1/Th2 balance” theory.CD4 + CD25 + Treg and Th17 cells,as well as their cytokines such as IL-10,transforming growth factor-β,and IL-17,account for asthma.CD4 + CD25 + Treg and Th17 are functionally antagonistic to each other,and also go with each other during their differentiation.Therefore,immunity-unbalance of CD4 + CD25 + Treg and Th17 is one of the most important factors that triggers asthma.Glucocorticoid has been shown to down regulate IL-17 expression by retinoic acid receptors γt signaling pathway,and regulate differentiation and function of CD4 + CD25 + Treg by inducing expression of transcription factor Foxp3,all of these are immuno-mechanisms of glucocorticoid in asthma treatment.

Objective:To investigate the diagnostic value of color Doppler flow imaging(CDFI) in the diagnosis of liver tumors.Methods: UE, CEUS, and CDFI were performed in 104 patients with liver cancer who were admitted to our hospital from January 2013 to December 2014, in order to analyze the diagnostic value of three methods for liver tumor compared with the pathological results.Results: The 115 masses of the group included 97 malignant masses(84.34%) and 18 benign masses(15.66%). The diagnostic accuracy of CDFI for benign and malignant liver tumors was 55.56% and 74.23%. There was no significant difference between UE and CDFI in the diagnosis of benign liver tumors and CEUS was higher than that of CDFI and UE in the diagnosis of benign and malignant liver tumors. There was no statistical difference in the diagnostic accuracy of CDFI combined with UE and CEUS(x2=2.20, P=0.138).Conclusion: CDFI is a basic method for the diagnosis of liver tumors. The CEUS or UE can be used to improve the accuracy of diagnosis for the liver which is not typical or small lesions.

Objective:To explore the mental health change among college freshmen,taking the age of late 1980,early 1990 and 1995 as the Qividing years.Method:We randomly selected 300 participants (total 900) in each period from the 2006-2015 year coollege freshman newborn psychological assessment data in a university in Xi'an.The data was analyzed by T-test and variance analysis.Results:There were significant differences among gender,family structure and the local institution in both China college students mental health scale (CCMHS) and college students' Psychological Adaptation (CCSAS).The level of mental health and psychological adaptation of college students after 95 is better than the students at the end of 80 and beginning of 90.Conclusion:College students' mental health and psychological adaptation level showed a trend of rising.But it still needs to carry out sexual mental health knowledge lecturer aiming at the existence of psychosexual disorder,continue to strengthen the newborn adaptability education and activities,establish required course of mental health and popularize mental health knowledge.

Coix seed has anti-tumor effect and the anti-tumor activity composition is coix seed oil. Researches show that inducing cancer cell apoptosis and angiogenesis inhibition and regulation of the immune and analgesic function are the major roles of coix seed oil. Clinical researches prove that the effect can be increased and the life quality of lung cancer patients can be improved and the survival time can be prolonged when coix seed oil is used to treating lung cancer combined with Chemotherapy and Radiotherapy. So it is widely used in the treatment of lung cancer.

Objective To explore the clinical efficacy of tirofiban in treatment of patients with high-risk non-ST-segment elevation of acute coronary syndrome (NSTE ACS),in order to improve the level of treatment effect. Methods 90 cases with high-risk NSTE ACS from January 2011 to April 2013 were randomly divided into control group and observation group. The control group were received treatments of conventional aspirin,clopidogrel, anticoagulation,coronary angiography (CAG)and percutaneous coronary intervention (PCI),while the observation group were added tirofiban therapy an the basis of control group. After the treatment,the differences of cardiovascular adverse events,thrombolysis in myocardial infarction (TIMI)flow grade and complications in both two group were observed and compared. Results There were significant differences in major adverse cardiovascular events in the distal vascular blockage,surgery without reflux,recurrent angina and myocardial infarction and post-PCI TIMI flow grade 2 and 3 (P<0.05),but not in bleeding complications,TIMI flow grade 0 and 1 before and after PCI treatment. Conclusion Tirofiban is safe and effective in treatment of high-risk NSTE ACS in interventional procedures. It can improve TIMI flow, increase tissue perfusion and reduce postoperative complications.

Objective To evaluate the efficacy of D98A,a newly developed superparamagnetic oral MRI contrast agent,in the diagnosis of abdomen.Methods Plain and contrast MRI after taking 500～1000 ml D98Ain 80 patients were performed by using different field strength MR scanners,and the sequences included T 1WI,T 2WI,and fat suppressed sequences.The contrast effect,distribution,influence on demonstration of contours of abdominal organs,and side effects were studied concerning this suspension.Results It showed that this oral contrast agent had good security character,wide consideration area,low cost,good contrast effect,and high value of clinical application.The gastrointestinal tracts appeared as hypointensity on various MR sequences,and thus,made them easy to be identified.The margins of abdominal organs were easier to be located after taking the contrast,and the distinction had statistical denotation.The demonstration rate of gastrointestinal tracts was raised from 10% to 89% after using D98A.There were no side-effects in all patients. Conclusion D98A is safe and effective in facilitating the localization of the abdominal organs.It can improve the accuracy in delineating the gastrointestinal tracts and in diagnosing the lesions of abdominal organs.

OBJECTIVEThe purpose of this study is to investigate the influence of cryogenic treatment and age-hardening heat treatment on the corrosion behavior of a dental casting Ag-Pd alloy.

METHODSA low gold content dental casting alloy composed of Ag-Pd-Cu-Au was prepared for this study. Corrosion test was performed according to ISO 10271:2001 dental metallie-corrosion test methods. Experimental specimens were casted according to a standard dental lost-wax casting procedure, treated with solution by heating the specimens to 900 degrees C, and immediately quenched in ice water. The specimens were then divided into four groups and subjected to heat treatment, cryogenic treatment, and heat treatment combined with cryogenic treatment. The specimens after the solution treatment were taken as control. The metallographic structures of the specimens were observed. The electrochemical parameters and the quantity of non-precious metallic ions released were evaluated via electrochemical and static immersion tests.

RESULTSMetallographic observation revealed that all the treatments resulted in a change in the microstructure of the alloy. The treatments were effective in improving the electrochemical parameters, such as an increase in Eocp and Ecorr and a decrease in Icorr (P < 0.05). The amount of non-noble metal ions released showed no difference compared with the control group (P > 0.05).

CONCLUSIONAfter different treatments, the antierosion properties of the alloy satisfied the ISO requirements. Age-hardening heat treatment and cryogenic treatment improved the corrosion resistance of the alloy.

Objective: To investigate the effect of helper T cells (Th1 and Th2) and its important significance in judging prognosis of patients with advanced lung cancer. Methods: Interferon-? (INF-?) and interleukin-4 (IL-4) in plasma and pleural effusion were detected by enzyme-linked immunoassay in patients with advanced lung cancer, IFN-? and IL-4 reflected activity of Thl and Th2 respectively. Results: The activity of Th1 in patients with advanced lung cancer was lower than that in normal persons in peripheral blood. For non-outstanding curative effect or progressive state of illness, the activity of Thl in patients of above 1 year survival time decreased in post-treatment than in pretreatment, the activity of Th2 increased in post-treatment. Conclusion: Activity of Helper T cells ( Th1, Th2 ) could be an important marker to diagnose lung cancer and judge prognosis in patients with advanced lung cancer.

Objective To study the mental hea lth of drug addicts and its correlation with addictive behavior. Method s 143 drug addicts in treatment were investigated and analyzed with The Symptom Checklist 90 and Addictive Behavior Questionnaire. Results The mental health of drug addicts was worse than that of normal peo ple, and somatization, depression, anxiety and psychopathy in the factor of SCL -90 had high proportion in high score field. Sex, having occupation or not, and living alone had no significant differences in SCL-90 score. The results of co rrelation analysis of mental health and addictive behavior were that the quantit y and frequency of drug use had positive correlation with mental health. The con trol power of drug use desire had negative correlation with mental health. Conclusion The mental health of drug addicts is worse, and addi ctive behavior is correlated with mental health.