Adolescent ; Adult ; Cholestasis ; drug therapy ; etiology ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Hepatitis, Viral, Human ; complications ; drug therapy ; Humans ; Male ; Middle Aged ; Phytotherapy

Objective To know the state of working satisfactory in appointment nurses, and then carry out certain countermeasures to promote their working satisfactory. Methods Investigated 137 ap-pointment nurses by serf-designed quesstionnair and JDI from five aspocts, to know their working satisfacto-ry and analyzed the resluts. Results The total points of working satisfactory in appointment nurses was 1882, which indicated that the level of working satisfactory was in a low state, the order of average points of working satisfactory in appointment nurses from low to more was promote, incomes, nursing cares, nursing management and yokemate. There were different working satisfactory in appointment nurses with different marital status, different working age, different operating post. Conclusions Effective nursing manage-ment, logical re, yard system and offer scope for nurses ability can promote their working satisfactory, and then ensure the stability of appointment nurses.

Objective:The aim of the present study was to determine the relation between coronary atherosclerosis and periarteries atherosclerosis by ultrasound measured as carotid and femoral artery structure and function and coronary angiograpgy. Methods: Subjects(75 cases) were divided into two groups according to coronary lesion and non-coronary lesion.Relation between coronary atherosclerosis lesion and multiple factors was found by analysis of clinical statues,laboratory test and sonograhpy. Results: Intima-media thickness in common carotid and femoral arteries,carotid plaques and invert peak and whole time on invert peak in femoral arteries were significantly higher in coronary lesion group than those in non-coronary lesion group(P

With the advance of modern imaging technologies,many examinations,especially for ultrasound,have been used for the screening examination of breast cancers.This article reviewed the character and prospect of ultrasound for breast cancers.

Atrial fibrillation is the most common arrhythmia disease in the clinical works,and endangers the public health seriously.With the development of AAD and ABL,we have made a great progress in AF's prevention and treatment.However,the literature and research about the non-disease causes of lone AF are very rare.So,the article will make a system review and summary about it,in order to instruct the lone AF's primary prevention.

Objective To understand clinical specimen hemolysis Staphylococcus (SHA)distribution characteristics and re-sistance and sensitivity to 20 kinds of antibiotics,reasonable to guide the clinical treatment of SHA infection.Methods Rou-tinely cultured and isolated bacteria.Used the United States BD Phoenix-100 automated microbial identification and suscepti-bility instrument to identify bacteria and susceptibility testing,and susceptibility testing all used the instrument broth dilu-tion method,according to the USA CLSI2015 [1]regulations standards.Results 162 strains of SHA from the distribution of age,children under the age was one of the highest (30.9%),and from the distribution department,mainly distributed in ped-iatrics (30.9%),department of critical care medicine (22.2%),medicine (17.3%),surgery (12.3%).From the specimen type distribution,were mainly distributed in the blood (33.3%),sputum (25.9%),wound (11.1%) and discharge (9.9%).In the 162 strains of SHA,the proportion of the MRSH was 93.8%,of which 152 strains of MRSH incidence of multiple drug resistance (MDR)was as high as 61.8%.Compared with MSSH,antibiotic resistance rate of MRSH was sig-nificantly higher.The resistance rate of MRSH to ampicillin,cefoxitin,penicillin G,erythromycin was extremely high,more than 98.7% the former of cefoxitin,penicillin G,ampicillin,erythromycin resistance was extremely high,more than 98.7%. The sensitive rate of both to rina thiazole amine,vancomycin,amikacin was 100%,and the rate to Fusidic acid,teicoplanin, nitrofurantoin was also high,more than 9 5.5%.Conclusion Linezolid,Vancomycin,Amikacin,Fusidic acid,Teicoplanin and Nitrofurantoin because all can be used as empiricaluse of SHA infection,other antibiotics chooses to in addition to drug sen-sitivity tests results.

BACKGROUND:Brain-derived neurotrophic factor has been detected in bone and tooth, and its role in development and metabolism of bone and tooth tissue as wel as its clinical application has become a hot spot. OBJECTIVE: To summarize and analyze the effect and mechanism of brain-derived neurotrophic factor in development and metabolism of bone and tooth tissues. METHODS: Papers addressing the effect of brain-derived neurotrophic factor in bone and tooth tissue were retrieved by computer in Wanfang and PubMed databases with the key words of “brain-derived neurotrophic factor, TrkB, p75NTR, signaling, bone, tooth, osteoblasts, osteoclasts” in Chinese and English, respectively. A total of 53 papers were included for review. RESULTS AND CONCLUSION:Brain-derived neurotrophic factor can be detected in various tissuesin vivo, and can regulate cel survival and apoptosis through binding its two receptors. Brain-derived neurotrophic factor in bone and tooth tissue can bind to target cels, induce or inhibit cel proliferation and differentiation, indicating that brain-derived neurotrophic factor is closely linked to bone and tooth tissue, and may play a role in growth and reconstruction of bone and tooth. Its mechanism of action is mainly through binding to TrkB receptor, to activate downstream pathways and affect differentiation and proliferation of mesenchymal stem cels, osteoblasts, chondrocytes, and periodontal ligament cels. Interaction between p75NTR receptor and TrkB receptor may be one of the factors affecting cel differentiation or proliferation.

Objective To elucidate the significance of CYFRA21-1 and β2-microglobulin expression in pleural fluid and develop diagnostic application for malignant pleural effusion differentiation. Methods Detected expression of CYFRA21-1 by RIA analysis and β2-MG by immunoturbidimetry assay (ITA), in 40 cases of benign pleural effusion and 40 cases of malignant pleural effusion. Results The mean level of CYFRA21-1 in malignant pleural effusions was (78.80±24.90)μg/L higher than that in benign pleural effusions (26.20±15.60)μg/L (P<0.05) and β2-MG in benign pleural effusions was (6.11±0.87)mg/L, significantly higher than that in malignant pleural effusions which was (3.12±0.91)mg/L respectively (P<0.05). Conclusion Evaluation of CYFRA21-1 and β2-MG in chest fluid can improve the differential diagnosis of malignant pleural effusion from benign pleural effusion and significantly increase the sensitivity of diagnosis.

OBJECTIVE:To explore the treatment effect and complication prevention of various stent materials for intracranial arteriostenosis.METHODS:A computer-based online search of Science Direct and Ei database (1998-01/2009-10) was performed for English articles with the key words of "intracranial arteriostenosis,stent placement" In addition,CNKI and CBM database (1998-01/2009-10) were searched for related Chinese articles with the same key words in Chinese.Moreover,related works were manually searched.Studies regarding various stent materials for intracranial arteriostenosis were included,including basic and clinical experiments.RESULTS:Multicenter studies of worldwide show that stent implantation displays obvious advantages in treating carotid artery stenosis compared with carotid endarterectomy.Recently,with developing of balloon and stent compliance,as well as stent technology,and application of various novel materials and cerebral protection device,stent has become a safe and effective therapy for intracranial arteriostenosis.However,complications following stent implantation,such as restenosis,ischemic stroke,cerebral hemorrhage hypertransfusion syndrome,and cerebral angiospasm,limit its application.CONCLUSION:The safety and efficacy of intracranial stent implantation remains validation of multicenter and perspective studies.High incidence of restenosis following stent implantation requires further improvement.

Camptothecin/*pharmacology ; Liver Neoplasms, Experimental/*immunology ; Neoplasm Transplantation ; Sarcoma, Experimental/*immunology ; Transplantation, Isogeneic