OBJECTIVE:To investigate the tissues distribution of monostearin solid lipid nanoparticles(MSLN)and MSLN(PEG-MSLN)that had been modified by PEG2000in vivo of mice and the pharmacokinetics in vivo of rats,and to investigate the influence of PEG2000modification on MSLN tissues distribution and pharmacokinetics.METHODS:MSLN was prepared by a novel solvent diffusion method.The particle diameters and Zeta potentials of MSLN were determined.Tissues distribu?tions and pharmacokinetics of2kinds of MSLN preparations in vivo of rats after vena caudalis administration were determined and the determining results were calculated with rhodamine B as fluorescent marker.RESULTS:2kinds of MSLN preparations showed a similar particle diameter distribution with Zeta potential of MSLN at—20mV.MSLN targeted to liver after vena caudalis intravenous injection and the general circulation of nanoparticles was significantly prolonged to2.2times after modified by PEG2000.CONCLUSION:MSLN can amelioration systemic circulation after modification with PEG2000and which can be used as liver-targeted drug carrier.

OBJECTIVE:To study the occurrences of adverse drug reactions(ADR)in our hospital for references of rational use of drugs in the clinic.METHODS:A total of 377 ADR cases collected in our hospital during the period 2005～2006 were analyzed statistically in respect of patients' age and sex,drug kinds,clinical manifestations and route of administration etc.RE-SULTS:Of the total 377 ADR cases,the number of drug kinds involved totaled 118,with antiinfective drugs taking the lead,accounting for 46.61%(55 kinds),283 cases were given intravenously.Lesions of skin and the appendants were the chief ADR types(49.87%);there were 17 severe cases.CONCLUSION:Great importance should be attached to ADR monitoring in the clinic.

With the advance of modern imaging technologies,many examinations,especially for ultrasound,have been used for the screening examination of breast cancers.This article reviewed the character and prospect of ultrasound for breast cancers.

OBJECTIVETo observe the effect of the postpone in skeletal muscle aging process of D-galactose rats by weight training and soy polypeptide supplement in 6 weeks, and discuss the initial mechanism.

METHODSixty male SD rats (three month old)were randomly assigned: 6 week control (C6,) and 6 week model (M6) 6 for each group, 12 week model (M12), big load (B12), small load (S12), peptide (P12), peptide + big load (PB12) and peptide + small load group (PS12) 8 for each group, eight fourteen month rats were taken in the natural aging group. The rats were killed by the end of 6th week and 12th week, tested the indicators.

RESULTCompare with group C6, the indicators in group M6 showed aging in different levels; Compare with group M12, weight training or soy polypeptide supplement in all intervention groups could increase the content of skeletal muscle superoxide dismutase (SOD), SOD/MDA, the serum growth hormone(GH), insulin-like growth factor-1 (IGF-I)and skeletal muscle IGF-I mRNA, decreased the malondialdehyde (MDA) content of skeletal muscle, and they had notable interaction.

CONCLUSIONRat skeletal muscle aging model can be copied successfully by D-galactose hypodermic, and go on with 6-week weight training or soy polypeptide supplement, they can postpone the skeletal muscle aging process of D-galactose rats, and the two interference way united can have more obvious effect. Its preliminary mechanism may be related to the reduction of skeletal muscle oxidative stress and lipid peroxidation, the correction of hormones and related factors metabolic disorders, the elevation of skeletal muscle IGF-I mRNA expression and so on.

Aging ; physiology ; Animals ; Galactose ; Growth Hormone ; blood ; Insulin-Like Growth Factor I ; metabolism ; Male ; Malondialdehyde ; metabolism ; Muscle, Skeletal ; drug effects ; physiology ; Physical Conditioning, Animal ; physiology ; Rats ; Rats, Sprague-Dawley ; Soybean Proteins ; pharmacology ; Soybeans ; chemistry ; Superoxide Dismutase ; metabolism

A cluster sampling method was used to select 5 Huaihai communities of Shanghai.All individuals were aged ≥60 years.Visual acuity without correction and presenting acuity with their habitual distance correction were measured separately for each eye.The prevalence of blindness and low vision was 0.49％ and 1.65％ respectively.The leading causes of blindness in a descending sequence included macular degeneration,cataract and retinal vascular disease.

Objective To summarize the experience of nursing pregnant women with hyperthyreosis. Methods A retrospective analysis of the nursing histories of 37 pregnant women with hyperthyreosis was done to summarize the nursing interventions of pregnancy-induced hypertension syndrome,heart failure and hyperthyroidism crisis. Results Among all the patients,6 cases developed with pregnancy-induced hypertension syndrome,4 with heart failure and 2 with hyperthyroidism crisis.They were cured and discharged due to treatments and nursing intervention. Conclusion Enhanced monitoring and nursing of perinatal complications is critical for pregnancy outcome of pregnant women with hyperthyreosis.

Objective To investigate the correlation among Lp (a),cerebral infarction and carotid atherosclerosis.Methods 180 cases were equally divided into 3 groups (60 cases in each group).The patients with both cerebral infarction and carotid atherosclerosis composed one group(cerebral infarction group for short) ;the patients of carotid atherosclerosis which without cerebral infarction composed another group(no cerebral infarction group for short) ;the control group composed with those who had neither cerebral infarction nor carotid atherosclerosis.The level,outlier detection rate about Lp(a) and usual risk factors of cerebral infarction were compared in this research.Results The level and detection rate of Lp(a) in the cerebral infarction group were (512 ± 156) mg/L and 46.7％ ;the level and detection rate of Lp(a) in the no cerebral infarction group were (316 ± 87)mg/L and 20.0％ ;the level and detection rate of Lp(a) in the control group were (199 ± 123) mg/L and 5.0％.The differences of the level and outlier detection rate of Lp(a) among the three group were significant(F=13.87,x2 =29.394,P ＜0.01).Cerebral infarction patients had more usual risk factors of cerebral infarction (hypertension,diabetes,hyperlipemia,drinking,smoking,obesity and lack of exercise) than those who without cerebral infarction (x2 =15.523,P ＜ 0.01).Conclusion The abnormal of Lp(a) was an important risk factor of cerebral infarction.The general survey of Lp(a) was significant in the primary and secondary prevention of stroke.To the people whose assay of Lp(a) was abnormal,the control of governable risk factors of cerebral infarction should actively be carried out.

Objective To investigate the common etiologies,sports and learning situation of children in Nantong with short stature,and discuss the relationship between the two. Methods Did a retrospective analysis of 108 cases of children with short stature in Nantong University′s affiliated hospital since January 2012. Through detailed past illnesses, physical examination, laboratory tests, diagnose short stature and clarify the cause. Did a questionnaire to these children with short stature about sports and learning situation. Use statistical methods like multivariate Logis-tic regression analysis and link analysis to analyze sports and learning situation of children in Nantong with short sta-ture and find the relation with the etiology. According to the principle of group matching,the control group elected representative of 108 children. Results In 108 cases, 61 cases were because of growth hormone deficiency (GHD), accounting for 56. 5% ; 47 cases were because of non-growth hormone deficiency (NGHD), accounting for 43. 5% . Logistic regression analysis showed that participation in physical exercise was a protective factor. Rest-less anxiety and inattention were as risk factors,and these make a lot(P < 0. 001, OR = 7. 483, 95% CI = 2. 620 ~21. 374). There was no significant relation between common cause and sports, learning situation ( P > 0. 05). Conclusion Various types of sports (basketball, badminton, running, cycling) are protective factors for children of short stature. Restless anxiety and inattention are risk factors for children with short stature. Whether there is growth hormone deficiency or not, children with short stature should increase the right exercise as much as possible and avoid or reduce exposure to these risk factors.

BACKGROUND:Gold nanorods have unique optical properties, good histocompatibility, easily control ed surface modification, which have a broad application prospect in the field of biology and medicine. OBJECTIVE:To summarize the optical and thermal properties of gold nanoparticles, and to review the mechanism and research advances of gold nanoparticles, especial y gold nanorods in tumor sensitize radiotherapy. METHODS:A computer-based search of PubMed and CNKI databases was undertaken with the keywords of“gold nanoparticles, radiotherapy sensitivity”in English and Chinese, respectively. The included articles were related to nanoparticles used in vitro and in vivo for clinic study as wel as gold nanoparticles-related tumor sensitize radiotherapy. RESULTS AND CONCLUSION:Gold nanoparticles exhibit unique properties of surface plasmon resonance properties. Compared with the traditional spherical gold nanoparticles, gold nanorods are capsule-like gold nanoparticles containing two absorption peaks that are a transverse surface plasmon resonance absorption peak and a longitudinal surface plasmon resonance absorption peak corresponding to the dimensional characteristics of their horizontal axis and vertical axis, respectively. By regulation of the ratio of horizontal axis and vertical axis, we can realize the manipulation of the longitudinal surface plasmon resonance absorption peak location. Thus, the longitudinal surface plasmon resonance absorption peak can be changed from visible region to the near-infrared region which is the most ideal optical transmission through for al of biological tissues. As a kind of novel radiotherapy sensitization agent, gold nanorods have the properties of low toxicity, high efficiency, high yield. Its sensitization effect is not only related to the exposure dose, own concentration and size, surface modified compounds, but also related to the types of radiation and celllines. However, for radiotherapy sensitization of gold nanorods how to avoid the limits of radioactive ray species, choose appropriate trim and maximize the use of gold nanorods stil need a further research.

ObjectiveTo observe the effect of different needle-retaining lengths on the clinical efficacy of acupuncture in treating post-stroke shoulder pain.MethodSixty patients were randomized into a 30 min group and a 60 min group, 30 cases in each group. The same acupuncture treatment protocol was adopted in the two groups, and the acupuncture treatment was given once a day, 5 sessions a week, for 20 times in total. The Visual Analogue Scale (VAS), shoulder pain frequency, and Fugl-Meyer Assessment (FMA) were observed before treatment and after 4-week treatment.ResultThe scores of each index were significantly improved in both groups after treatment (P<0.01), and there were significant differences in comparing each index score between the two groups after treatment (P<0.05,P<0.01).ConclusionIn the treatment of post-stroke shoulder pain with acupuncture, 30 min needle-retaining is better than 60 min in comparing the analgesic effect.