1.Diagnosis and treatment of patients with cholangiocarcinoma.
Jian-Xiong WU ; Shi-Jie HU ; Wei-Qi RONG ; Li-Ming WANG ; Yong-Fu SHAO
Acta Academiae Medicinae Sinicae 2006;28(3):332-334
OBJECTIVETo explore the diagnosis and treatment of the cholangiocarcinoma.
METHODSForty one patients with cholangiocarcinoma who were enrolled in our hospital from January 1970 to January 2005 were retrospectively analyzed.
RESULTSAmong these 41 patients, the 1, 3, and 5-year survival rate was 82.3%, 45.8%, 45.8%, respectively, with radical operation, and was 11.0%, 0, 0 with non-radical operation (chi2 = 21.38, P < 0.01). The 1-year and 3-year survival rate was 11.0% and 0 in 9 patients treated with laparatomy, which was not significantly different from those treated with non-radical operation (chi2 = 0.02, P = 0.89). Four patients did not receive operation and all died within one year. Among 25 patients who did not experience lymph node metastasis, the 1, 3, and 5-year survival rate was 58.4%, 27.3%, and 27.3%. Among 16 patients who were found lymph node metastasis, the 1-year and 3-year survival rate was 61.8% and 0 (chi2 = 13.85, P < 0.01).
CONCLUSIONOperation is the most effective treatment for cholangiocarcinoma. Radical operation is the only curative treatment.
Bile Duct Neoplasms ; diagnosis ; pathology ; therapy ; Bile Ducts, Intrahepatic ; Cholangiocarcinoma ; diagnosis ; secondary ; therapy ; Female ; Humans ; Lymphatic Metastasis ; Male
2.Villous adenoma of the bile ducts: a case report and a review of the reported cases in Korea.
Bo Won CHAE ; Jun Pyo CHUNG ; Young Nyun PARK ; Dong Sup YOON ; Jeong Sik YU ; Se Joon LEE ; Kwan Sik LEE ; Jae Bock CHUNG ; Sang In LEE ; Young Myoung MOON ; Jin Kyung KANG
Yonsei Medical Journal 1999;40(1):84-89
Villous adenomas are benign epithelial lesions with malignant potential which can occur at any site in the gastrointestinal tract. They are usually encountered in the rectum and colon, less frequently in the small bowel and very rarely in the biliary trees. Nine cases of bile duct villous adenomas have been reported in the literature. However, 4 cases of bile duct villous adenomas have been reported in the Korean literature. Recently, we experienced a case of villous adenoma in the common hepatic duct in a 77-year-old man presenting with obstructive jaundice in which preoperative histologic diagnosis of villous adenoma played a critical role in managing this patient. Herein, we present a case report of bile duct villous adenoma and a review of the reported cases in Korea to help define and manage this rare disease entity in the bile ducts. In addition, confusing nomenclature of bile duct adenomas is discussed.
Adenoma, Villous/therapy*
;
Adenoma, Villous/diagnosis
;
Aged
;
Bile Duct Neoplasms/therapy*
;
Bile Duct Neoplasms/diagnosis
;
Case Report
;
Cholestasis/etiology
;
Human
;
Male
3.A Case of Biliary Papillomatosis with Cystic Dilatation of Bile Duct.
Yoo Mi PARK ; Kwangwon RHEE ; Sun Och YOON ; Ji Yoon HA ; So Young PARK ; Jung Ho LEE ; Sung Ill JANG
Yeungnam University Journal of Medicine 2012;29(2):136-140
A 61-year-old male who complained of right upper quadrant pain was referred to the authors for evaluation after his computed tomography suggested biliary adenocarcinoma. The lesion consisted of multiple cysts with papillary mass and peri-ampullay mass. The patient underwent an operation due to a clinical suspicion of biliary cystadenocarcinoma, but the pathology confirmed biliary papillomatosis (BP) after diagnosing intrahepatic papillary neoplasm with high-grade dysplasia and invasive adenocarcinoma with papillary neoplasm from the distal common bile duct to the duodenum. BP is a disease characterized by multiple papillary masses. Its cause has yet to be discovered. It commonly manifests as bile duct dilation but rarely as a ductal cystic change. Under computed tomography or magnetic resonance imaging, both the BP and the cystic neoplasm can show bile duct dilation and a papillary mass, which makes their differential diagnosis difficult. A confirmative diagnosis can be made through a pathologic examination. BP is classified as a benign disease that can become malignant and may recur, though rarely. Its treatment of choice is surgical resection. Laser ablation or photodynamic therapy can be used for unresectable lesions. In the case featured in this paper, biliary papillomatosis was difficult to differentiate from cystic adenocarcinoma due to diffusely scattered multiple large cystic lesions in the liver, and it was histologically confirmed to have become malignant with cystic duct dilation after the operation. This case is reported herein with a literature review.
Adenocarcinoma
;
Bile
;
Bile Ducts
;
Biliary Tract Neoplasms
;
Common Bile Duct
;
Cystadenocarcinoma
;
Cystic Duct
;
Diagnosis, Differential
;
Dilatation
;
Duodenum
;
Humans
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Laser Therapy
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Liver
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Magnetic Resonance Imaging
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Male
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Papilloma
;
Photochemotherapy
4.Metastatic mucinous adenocarcinoma of the distal common bile duct, from transverse colon cancer presenting as obstructive jaundice.
Doo Ho LEE ; Young Joon AHN ; Rumi SHIN ; Hae Won LEE
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2015;19(3):125-128
The patient was a 70-year-old male whose chief complaints were obstructive jaundice and weight loss. Abdominal imaging studies showed a 2.5 cm sized mass at the distal common bile duct, which was suggestive of bile duct cancer. Eccentric enhancing wall thickening in the transverse colon was also shown, suggesting concomitant colon cancer. A colonoscopy revealed a lumen-encircling ulcerofungating mass in the transverse colon, that was pathologically proven to be adenocarcinoma. The bile duct pathology was also adenocarcinoma. Pylorus-preserving pancreaticoduodenectomy and extended right hemicolectomy were performed under the diagnosis of double primary cancers. Postoperative histopathologic examination revealed moderately differentiated mucinous adenocarcinoma of transverse colon cancer, and mucinous adenocarcinoma of the distal common bile duct. Immunohistochemical staining studies showed that the bile duct cancer had metastasized from the colon cancer. The patient recovered uneventfully from surgery and will be undergoing chemotherapy for three months.
Adenocarcinoma
;
Adenocarcinoma, Mucinous*
;
Aged
;
Bile Duct Neoplasms
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Bile Ducts
;
Colon, Transverse*
;
Colonic Neoplasms
;
Colonoscopy
;
Common Bile Duct Neoplasms
;
Common Bile Duct*
;
Diagnosis
;
Drug Therapy
;
Humans
;
Jaundice, Obstructive*
;
Male
;
Mucins*
;
Neoplasm Metastasis
;
Pancreaticoduodenectomy
;
Pathology
;
Weight Loss
5.Pathologic Complete Remission in a Patient with Locally Advanced Unresectable Intrahepatic Cholangiocarcinoma Treated with Chemotherapy.
Hyo Jun YANG ; Ji Kon RYU ; Woo Hyun PAIK ; Sang Hyub LEE ; Yong Tae KIM ; Kyoungbun LEE
Korean Journal of Pancreas and Biliary Tract 2017;22(4):188-192
A 54-year-old female with postprandial dyspepsia and abdominal pain was diagnosed as locally advanced unresectable intrahepatic cholangiocarcinoma by radiologic imaging studies resulting in invasion to bilateral main bile duct and right portal vein. The patient underwent extended right hepatectomy and portal vein resection after gemcitabine and cisplatin combined chemotherapy for a total of 40 cycles after the diagnosis. Final pathology showed, followed by pathological complete remission, without any residual cancer cell. The patient has survived for over 6 years without any evidence of recurrence. This case suggests that locally advanced intrahepatic cholangiocarcinoma, which can't be resected, was also proved to be capable of pathological complete remission with active chemotherapy, and long-term survival could be achieved. Therefore, active multidisciplinary approach and patient-oriented treatments using various methods should be considered for locally advanced unresectable intrahepatic cholangiocarcinoma.
Abdominal Pain
;
Bile Duct Neoplasms
;
Bile Ducts
;
Cholangiocarcinoma*
;
Cisplatin
;
Diagnosis
;
Drug Therapy*
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Dyspepsia
;
Female
;
Hepatectomy
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Humans
;
Middle Aged
;
Neoplasm, Residual
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Pathology
;
Portal Vein
;
Recurrence
6.A Case of Clonorchiasis Presenting as Common Bile Duct Mass.
The Korean Journal of Gastroenterology 2010;56(4):211-213
No abstract available.
Aged, 80 and over
;
Animals
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Anthelmintics/therapeutic use
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Bile Duct Neoplasms/diagnosis/surgery/ultrasonography
;
Cholangiopancreatography, Endoscopic Retrograde
;
Clonorchiasis/*diagnosis/drug therapy/surgery
;
Clonorchis sinensis/isolation & purification
;
Common Bile Duct/ultrasonography
;
Humans
;
Male
;
Praziquantel/therapeutic use
;
Tomography, X-Ray Computed
7.Adenosquamous Carcinoma of Extrahepatic Bile Duct: A Case Report.
Sin Hyung LIM ; Hyeon Woong YANG ; Anna KIM ; Sang Woo CHA ; Sung Hee JUNG ; Hoon GO ; Woong Chul LEE
The Korean Journal of Internal Medicine 2007;22(3):206-210
Most malignant tumors originating from the biliary tract are adenocarcinomas, and adenosqamous carcinoma of Klatskin's tumor is a very rare finding. An 83-yr-old man was admitted to our hospital because of jaundice. The abdominal computed tomography and magnetic resonance cholangiopancreatography revealed wall thickening and luminal stenosis of both the intrahepatic duct confluent portion and the common hepatic duct. These findings were compatible with Klatskin's tumor, Bismuth type III. Considering the patient's old age, palliative combined modality therapy was performed. After percutaneous transhepatic biliary drainage, biopsy was performed via percutaneous transhepatic cholangioscopy. The histopathologic findings showed adenosquamous carcinoma. External radiotherapy and intraluminal brachytherapy through the endobiliary Y-type stent were then done. Nine months after the radiotherapy, the laboratory findings and the abdominal computed tomography revealed biliary obstruction and progressive hepatic metastasis. The combined modality therapy of external radiotherapy, intraluminal brachytherapy and stenting assisted him to live a normal life until he finally experienced biliary obstruction.
Aged, 80 and over
;
Bile Duct Neoplasms/*diagnosis/therapy
;
*Bile Ducts, Extrahepatic
;
Carcinoma, Adenosquamous/*diagnosis/therapy
;
Cholangiography
;
Combined Modality Therapy
;
Humans
;
Jaundice/etiology
;
Male
;
*Palliative Care
;
Stents
;
Tomography, X-Ray Computed
8.Development of Brugada Syndrome Following Photodynamic Therapy in a Patient with Cholangiocarcinoma.
Duk Won BANG ; Min Su HYON ; Young Duk CHO ; Sung Koo KIM ; Young Joo KWON
The Korean Journal of Internal Medicine 2012;27(1):95-97
Brugada syndrome can be unmasked by several conditions including a febrile state, marked leukocytosis, and electrolyte disturbances. Herein, we describe a 62-year-old man with cholangiocarcinoma in the first reported case of Brugada syndrome onset following photodynamic therapy.
Bile Duct Neoplasms/*drug therapy
;
*Bile Ducts, Intrahepatic
;
Brugada Syndrome/diagnosis/*etiology/therapy
;
Cardiopulmonary Resuscitation
;
Cholangiocarcinoma/*drug therapy
;
Electrocardiography
;
Fatal Outcome
;
Fever/etiology
;
Humans
;
Klatskin's Tumor/*drug therapy
;
Male
;
Middle Aged
;
Photochemotherapy/*adverse effects
;
Predictive Value of Tests
;
Treatment Outcome
9.Excerpt from the 2022 American Association for the Study of Liver Diseases clinical practice guideline: management of primary sclerosing cholangitis and cholangiocarcinoma.
Chinese Journal of Hepatology 2023;31(1):35-41
What are the new contents of the guideline since 2010?A.Patients with primary and non-primary sclerosing cholangitis (PSC) are included in these guidelines for the diagnosis and management of cholangiocarcinoma.B.Define "related stricture" as any biliary or hepatic duct stricture accompanied by the signs or symptoms of obstructive cholestasis and/or bacterial cholangitis.C.Patients who have had an inconclusive report from MRI and cholangiopancreatography should be reexamined by high-quality MRI/cholangiopancreatography for diagnostic purposes. Endoscopic retrograde cholangiopancreatography should be avoided for the diagnosis of PSC.D. Patients with PSC and unknown inflammatory bowel disease (IBD) should undergo diagnostic colonoscopic histological sampling, with follow-up examination every five years until IBD is detected.E. PSC patients with IBD should begin colon cancer monitoring at 15 years of age.F. Individual incidence rates should be interpreted with caution when using the new clinical risk tool for PSC for risk stratification.G. All patients with PSC should be considered for clinical trials; however, if ursodeoxycholic acid (13-23 mg/kg/day) is well tolerated and after 12 months of treatment, alkaline phosphatase (γ- Glutamyltransferase in children) and/or symptoms are significantly improved, it can be considered to continue to be used.H. Endoscopic retrograde cholangiopancreatography with cholangiocytology brushing and fluorescence in situ hybridization analysis should be performed on all patients suspected of having hilar or distal cholangiocarcinoma.I.Patients with PSC and recurrent cholangitis are now included in the new unified network organ sharing policy for the end-stage liver disease model standard.J. Liver transplantation is recommended after neoadjuvant therapy for patients with unresectable hilar cholangiocarcinoma with diameter < 3 cm or combined with PSC and no intrahepatic (extrahepatic) metastases.
Child
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Humans
;
Cholangitis, Sclerosing/diagnosis*
;
Constriction, Pathologic/complications*
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In Situ Hybridization, Fluorescence
;
Cholangiocarcinoma/therapy*
;
Liver Diseases/complications*
;
Cholestasis
;
Inflammatory Bowel Diseases/therapy*
;
Bile Ducts, Intrahepatic/pathology*
;
Bile Duct Neoplasms/therapy*
10.Large Cell Neuroendocrine Carcinoma of the Extrahepatic Bile Duct.
The Korean Journal of Gastroenterology 2018;72(6):318-321
Primary neuroendocrine tumors originating from the extrahepatic bile duct are rare. Among these tumors, large cell neuroendocrine carcinomas (NECs) are extremely rare. A 59-year-old man was admitted to Sanggye Paik Hospital with jaundice that started 10 days previously. He had a history of laparoscopic cholecystectomy, which he had undergone 12 years previously due to chronic calculous cholecystitis. Laboratory data showed abnormally elevated levels of total bilirubin 15.3 mg/dL (normal 0.2–1.2 mg/dL), AST 200 IU (normal 0–40 IU), ALT 390 IU (normal 0–40 IU), and gamma-glutamyl transferase 1,288 U/L (normal 0–60 U/L). Serum CEA was normal, but CA 19-9 was elevated 5,863 U/mL (normal 0–37 U/mL). Abdominal CT revealed a 4.5 cm sized mass involving the common bile duct and liver hilum and dilatation of both intrahepatic ducts. Percutaneous transhepatic drainage in the left hepatic duct was performed for preoperative biliary drainage. The patient underwent radical common bile duct and Roux-en-Y hepaticojejunostomy for histopathological diagnosis and surgical excision. On histopathological examination, the tumor exhibited large cell NEC (mitotic index >20/10 high-power field, Ki-67 index >20%, CD56 [+], synaptophysin [+], chromogranin [+]). Adjuvant concurrent chemotherapy and radiotherapy were started because the tumor had invaded the proximal resection margin. No recurrence was detected at 10 months by follow-up CT.
Bile Duct Neoplasms
;
Bile Ducts, Extrahepatic*
;
Bilirubin
;
Carcinoma, Neuroendocrine*
;
Cholecystectomy, Laparoscopic
;
Cholecystitis
;
Common Bile Duct
;
Diagnosis
;
Dilatation
;
Drainage
;
Drug Therapy
;
Follow-Up Studies
;
Hepatic Duct, Common
;
Humans
;
Jaundice
;
Liver
;
Middle Aged
;
Neuroendocrine Tumors
;
Radiotherapy
;
Recurrence
;
Synaptophysin
;
Tomography, X-Ray Computed
;
Transferases