Objective To master the influential factors of compassion fatigue of nurses in infectious disease hospital and the ways of nurses coping with high compassion fatigue , and to avoid job burnout because of high compassion fatigue .Methods Based on the Edmund Husseri ’ s phenomenological method , we used personal interviews to investigate 7 nurses in a grade-Ⅲ level-A infectious disease hospital .The data were analyzed by phenomenological analytical method .Results The suitable compassion fatigue of nurses could help them finish their work , while high compassion fatigue would lead to job burnout .Conclusions In order to avoid job burnout because of high compassion fatigue , nurse manager should take effective measures to guide nurses coping with it.