Objective: 1.To analyze the nutritional composition and evaluation of the nutritional value of Mortierella isabelina powder. 2.To investigate the effects of Mortierella isabelina powder on prevention and regulation of hyperlipidemia in rats. Methods: 1. Mycelium powder was analyzed for proteins, lipids polysaccharides, fibre, ash, vitamin E, amino acids, fatty acids and minerals. 2. Mycelium powder was used to feed rats in different dosages together with high lipid diet for 10 days. 3. Mycelium powder was used to feed hyperlipidemic rats in different dosages for 30 days. Results: (1) There were about 20% of proteins and more than 50% of lipids in the mycelium. Further examination found that the mycelium contained rich essential amino acids and unsaturated fatty acids. The mycelium also contained vitamin E and useful minerals such as K, Ca, P, Fe, Zn and Mn. (2) 0.6 or 1.2 g/(kg?d) dosage of mycelium powder could prevent the rise of serum lipids. (3) When the mycelium powder was used to feed hyperlipidemic rats, the serum cholesterol, triglyceride, LDL C and VLDL C of the rats could be reduced, meanwhile HDL C could be increased. Conclusion: The results indicated that Mortierella isabelina powder has potential nutritional value and can be used to regulate the blood lipids in hyperlipidemic rats.

OBJECTIVE: To present the experience of nasal reconstruction with forehead flap. METHOD: nasal reconstruction with forehead flap were applied in eight nasal carcinoma cases after operation and 5 nasal trauma cases with defects. RESULT: These forehead flaps were alive in all patients, all incision healed in I stage, no post operative complications were found. The shapes of nose were satisfactory, there were no recurrence of tumor during 1 to 17 year follow up. CONCLUSION The method can be clinically applied for its simple procedure, reliable flap's blood supply, high survival rate and satisfied result.
Adolescent ; Adult ; Aged ; Female ; Forehead ; surgery ; Humans ; Male ; Middle Aged ; Nose ; injuries ; surgery ; Rhinoplasty ; methods ; Skin Transplantation ; Surgical Flaps ; Young Adult

Objective:To observe and compare the changes of pulmonary function in patients with pulmonary tuberculosis regular treatment for 3 months.Methods:From April 2018 to June 2019, 500 tuberculosis patients who received regular anti tuberculosis treatment in our hospital were selected.The pulmonary function of patients with pulmonary tuberculosis was measured before treatment and at the end of three months; the results of pulmonary ventilation function, lung volume, diffusing capacity, and the value of forced vital capacity (FVC), maximum expiratory volume in 1 second (FEV 1), maximum expiratory volume in 1 second/forced vital capacity (FEV 1/FVC), total lung volume (TLC), residual volume (RV), carbon monoxide diffusing capacity (D LCO) were compared. Results:252 patients with pulmonary tuberculosis were included. Before treatment and at the end of three months, the abnormal pulmonary function results were 204 cases (80.95%) and 193 cases (76.59%), respectively, and the difference was not statistically significant ( P>0.05). Among them, abnormal pulmonary ventilation function is the most common, especially with obstructive, followed by abnormal diffusing capacity. At the end of three months, the proportions of patients with normal pulmonary ventilation function and normal lung volume were higher than that before treatment ( P<0.05), but there was no significant difference in the proportion of normal diffusing capacity before and after treatment ( P>0.05). The values of FVC, FEV 1, TLC and D LCO at the end of three months were higher than those before treatment, and the difference was statistically significant ( t=-6.414, -6.754, -3.863, -3.311, all P<0.01). Conclusions:Most patients with pulmonary tuberculosis have abnormal pulmonary function. At the end of the three months treatment, the normal rates of the pulmonary ventilation function and lung volume as well as the values of FVC, FEV 1, TLC and D LCO in patients with pulmonary tuberculosis were significantly improved compared with those before treatment.

Objective To analyze the identification and antibiotics susceptibility of infectious bacteria obtained from the topic skin infection during soft tissue expander implantation.Methods A retrospective analysis of 121 cases with local infections during soft tissue expander implantation between 2003 to 2012 in Department of Plastic and Reconstructive Surgery,Xijing Hospital was performed.The efficacy of clinical management of local infection was evaluated.Laboratory examination on exudates bacterial pathogen and antibiotic susceptibility were performed.Results Based on the severity of wound infection,change of dressings,wound debridement,exudates drainage and intravenous antibiotics administration were applied.All infections were successfully controlled although the expanders were removed in 16 cases with severe infections.Total success rate of expansion in this cohort was 89.33％.Twenty-nine exudates samples collected from either skin rupture wounds or skin outlets of connector tubes of externally placed infusion ports in 29 patients underwent bacterial culture and antibiotic susceptibility test.The 23 samples showed positive while the rest 6 samples showed negative on bacterial identification in the bacterial culture test.Staphylococcus aureus strain was found in 20 samples (86.96％),Staphylococcus epidermidis in 1 sample,Klinefelter Citrobacter in 1 sample,and Aeromonas hydrophila in 1 sample.More than 80％ of the pathogens were susceptive to cefazolin,oxacillin,and levofloxacin.Conclusions Staphylococcus aureus is the main pathogen of infection at expander implantation site.The local dressing change,surgical debridement,continuous infusion drainage,and the use intravenous antibiotics are the effective managements.

Objective To analyze the identification and antibiotics susceptibility of infectious bacteria obtained from the topic skin infection during soft tissue expander implantation.Methods A retrospective analysis of 121 cases with local infections during soft tissue expander implantation between 2003 to 2012 in Department of Plastic and Reconstructive Surgery,Xijing Hospital was performed.The efficacy of clinical management of local infection was evaluated.Laboratory examination on exudates bacterial pathogen and antibiotic susceptibility were performed.Results Based on the severity of wound infection,change of dressings,wound debridement,exudates drainage and intravenous antibiotics administration were applied.All infections were successfully controlled although the expanders were removed in 16 cases with severe infections.Total success rate of expansion in this cohort was 89.33％.Twenty-nine exudates samples collected from either skin rupture wounds or skin outlets of connector tubes of externally placed infusion ports in 29 patients underwent bacterial culture and antibiotic susceptibility test.The 23 samples showed positive while the rest 6 samples showed negative on bacterial identification in the bacterial culture test.Staphylococcus aureus strain was found in 20 samples (86.96％),Staphylococcus epidermidis in 1 sample,Klinefelter Citrobacter in 1 sample,and Aeromonas hydrophila in 1 sample.More than 80％ of the pathogens were susceptive to cefazolin,oxacillin,and levofloxacin.Conclusions Staphylococcus aureus is the main pathogen of infection at expander implantation site.The local dressing change,surgical debridement,continuous infusion drainage,and the use intravenous antibiotics are the effective managements.

Objective To investigate the effect of lead exposure on blood pressure of lead workers. Methods A total of 665 lead workers from some lead-acid battery enterprises in Wuhan were selected as the lead exposure group, and 708 ordinary workers without lead exposure were selected as the control group. The blood pressure in the workers of both groups was measured. The blood lead concentrations were measured in the lead-exposed group. The independent samples t-test was used to compare the blood pressure between the two groups. Linear regression model was used to analyze the relationship between the blood lead concentration and the blood pressure in the lead-exposed group. Logistic regression analysis was used to analyze the relationship between the risk of hypertension and blood lead concentration in lead-exposed group. Results The mean values of systolic blood pressure, diastolic blood pressure and pulse in the lead exposure group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in pulse pressure difference between the two groups (P>0.05). Linear regression analysis revealed that blood lead concentrations were significantly correlated with both systolic and diastolic blood pressure in the lead exposure group. For each increase of 1μg/L of blood lead concentration in the lead exposure group, the systolic blood pressure of lead workers increased by 0.011 mmHg, and the diastolic blood pressure increased by 0.007 mmHg. Logistic regression analysis found that men in the lead-exposed group had a higher risk of hypertension than women. The older the age and the higher the blood lead concentration, the higher the risk of development of hypertension. Conclusion There is a positive correlation between the blood lead concentration and the systolic and diastolic blood pressure in lead workers. The older the lead worker, the higher the risk of developing high blood pressure. The higher the lead concentration in lead workers, the higher the risk of developing high blood pressure.

To promote the development of extracellular vesicles of herbal medicine especially the establishment of standardization, led by the National Expert Committee on Research and Application of Chinese Herbal Vesicles, research experts in the field of herbal medicine and extracellular vesicles were invited nationwide with the support of the Expert Committee on Research and Application of Chinese Herbal Vesicles, Professional Committee on Extracellular Vesicle Research and Application, Chinese Society of Research Hospitals and the Guangdong Engineering Research Center of Chinese Herbal Vesicles. Based on the collation of relevant literature, we have adopted the Delphi method, the consensus meeting method combined with the nominal group method to form a discussion draft of "Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles (2023)". The first draft was discussed in online and offline meetings on October 12, 14, November 2, 2022 and April and May 2023 on the current status of research, nomenclature, isolation methods, quality standards and research applications of extracellular vesicles of Chinese herbal medicines, and 13 consensus opinions were finally formed. At the Third Academic Conference on Research and Application of Chinese Herbal Vesicles, held on May 26, 2023, Kewei Zhao, convenor of the consensus, presented and read the consensus to the experts of the Expert Committee on Research and Application of Chinese Herbal Vesicles. The consensus highlights the characteristics and advantages of Chinese medicine, inherits the essence, and keeps the righteousness and innovation, aiming to provide a reference for colleagues engaged in research and application of Chinese herbal vesicles at home and abroad, decode the mystery behind Chinese herbal vesicles together, establish a safe, effective and controllable accurate Chinese herbal vesicle prevention and treatment system, and build a bridge for Chinese medicine to the world.

A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-N
Animals ; Interneurons/metabolism* ; Mice ; Mice, Transgenic ; Nerve Tissue Proteins/metabolism* ; Neurons/metabolism* ; Nucleus Accumbens/metabolism* ; Parvalbumins/metabolism*

A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-N