Recent evidence has increasedly supposed cancer stem cell theory.that cancers can be viewed as an abnormal organ in which tumor growth is driven by a population of cancer stem cells,with self-re-hewing and muti-differentiation potentiality.CD133 has been repofled sequentially in many malignan-cies.Although the biological function of CD133 is not well understood.the CD133 epitope cueeently senves as a useful marker for the isolation of cancer stem cells.Research has discovered that CD133+ tumor cells are in re-lation to tumorigenesis,invasion,metastasis,drug-resistance and recurrence.So,understanding the molecular bi-ology of the CD133+ tumor cells is essential for developing more effective anti-cancer tIeatments,especiallv tar-geting cancer stem cells.

Objective To study the clinicopathologic characteristics and the prognostic factors of gastric stump cancer (GSC). Methods A total of forty-seven patients with GSC from Jan 2000 to Dec 2006 were enrolled in this study for retrospective analysis. Initial surgery was performed for gastric benign disease in 39 patients and for malignant disease in 8 patients, which were divided into 2 groups for analysis. The prognosis of all 47 patients were analyzed. Results The mean interval between previous gastrectomy and diagnosis of GSC was 24.4 years. Tumor developed mostly in the patients with Billroth- Ⅱ reconstruction, and male more than female. Tumor located at anastomotic site mostly, at stump stomach and cardia secondly. The mean interval for patients who had undergone their first gastrectomy for malignant disease was shorter than that with benign disease(P＜0.05). Histology, therapy and prognosis showed no significant differences between two groups (P＞0.05). Disease TNM stage and total radical gastrectomy were shown to be significant predictor for the outcome of patients with GSC (P ＜0.01). Conclusion Now the GSC patients with initial surgery performed for malignant disease are increased, which are no siginificant different to patients with benign disease. Early diagnosis and an aggressive surgical approach are crucial to achieve better outcomes for patients with GSC.

BACKGROUND:For on-visit root canal therapy, ultrasound washing can improve the quality of root canal irrigation, and play a synergistic role with ultrasound so that the flushing fluid can reach the area that cannot be completely cleaned up by root canal preparation instruments, such as apical isthmus and col ateral root canal, for removal of the detritus, cleanup and disinfection. ＜br> OBJECTIVE:To evaluate the clinical effect of one-visit root treatment with nickel-titanium rotary instruments and ultrasonic irrigation unit in treatment of chronic apical periodontitis. ＜br> METHODS:A total of 460 patients with il ed 460 teeth were selected. Patients were randomly divided into three groups:Mtwo instrument and ultrasonic technique combined with sodium hypochlorite was utilized in group A;ultrasonic technique combined with active silver ion antibacterial solution was utilized in group B;stainless steel K files with saline and hydrogen peroxide solution were used as irrigations in group C. Twenty-four hours after root canal fil ing, the pain degree was self-assessed by patients with visual analogue scale, and subsequent visit was done 7 days after root canal fil ing. Six and twelve months after root canal fil ing, the therapeutic effect was determined with X-ray examination and clinical assessment. ＜br> RESULTS AND CONCLUSION:The degree of pain and occurrence rate of acute reactions in groups A and B were significantly lower than those in group C (P＜0.05), but there was no significant difference between groups A and B (P>0.05). Six months after root canal fil ing, the cure rate was not significantly different between three groups (P>0.05). But after 12 months, the cure rate in the group C was significantly lower than that in groups A and B (P＜0.05). By using of nickel-titanium rotary instruments and ultrasonic irrigation unit in treatment of chronic apical periodontitis, the short-and long-term effects of one-visit root treatment have been achieved clinical y.

OBJECTIVE: To present the experience of nasal reconstruction with forehead flap. METHOD: nasal reconstruction with forehead flap were applied in eight nasal carcinoma cases after operation and 5 nasal trauma cases with defects. RESULT: These forehead flaps were alive in all patients, all incision healed in I stage, no post operative complications were found. The shapes of nose were satisfactory, there were no recurrence of tumor during 1 to 17 year follow up. CONCLUSION The method can be clinically applied for its simple procedure, reliable flap's blood supply, high survival rate and satisfied result.
Adolescent ; Adult ; Aged ; Female ; Forehead ; surgery ; Humans ; Male ; Middle Aged ; Nose ; injuries ; surgery ; Rhinoplasty ; methods ; Skin Transplantation ; Surgical Flaps ; Young Adult