Objective To investigate the effect of clinical nursing pathway on patients with cerebral infarction. Methods Two hundred patients with cerebral infarction were randomized by random digit table into the clinical pathway group and the conventional nursing group.The former was managed with the clinical nursing pathway and the latter received conventional nursing. The neurologic impairment and the activities of daily life were assessed respectively by national institute of health stroke scale(NIHSS) and Barthel index(BI).The two groups were compared in terms of hospital stay,medical expense,patient’s satisfaction and curative effect. Results Compared to the conventional nursing group,the clinical pathway group was shorter at hospital stay,lower at lower hospitalization cost,higher at patient’s satisfaction and higher in the score by Barthel index,compared to the conventional nursing group(all P<0.05). Conclusion The application of clinical nursing pathway in patients with cerebral infarction can improve the activities of daily living and the quality of care,shorten length of stay,reduce medical cost and increase patients’satisfaction drgree.

Ulcerative colitis (UC) is a chronic non-specific intestinal inflammatory disease. Whether surgical treatment should be taken is a difficult and focus decision of clinical practice. Studies have shown that severe complications, combined with severe infection, poor laboratory indices, and ineffective medical treatment are the evaluation elements of UC surgery. This article reviewed the advances in study on high risk factors of surgery with UC.

OBJECTIVETo investigate the value of serum IgA/C3 ratio in the diagnosis of IgA nephropathy and explore its relationship with the clinicopathological features of the patients.

METHODSSixty-six patients with IgA nephropathy, 111 with other glomerular diseases, and 40 healthy control subjects without kidney disease were tested for serum IgA and C3 levels using CRM470 adjusted standardized immune turbidimetric method, and the IgA/C3 ratio was calculated. According to Oxford and Lee's classification criteria, we analyzed the pathological grades of the renal biopsy samples from patients with IgA nephropathy. The ROC curve was used to assess the value of serum IgA and IgA/C3 ratio in predicting IgA nephropathy.

RESULTSPatients with IgA nephropathy had an elevated serum IgA/C3 ratio than those with other glomerular diseases and the control subjects, with an area under the ROC curve of 0.776. An elevated serum IgA/C3 ratio was not found to significantly correlate with the pathological grade of renal biopsy samples in patients with IgA nephropathy.

CONCLUSIONIn the absence of renal biopsy findings, serum IgA/C3 ratio can help in the diagnosis of IgA nephropathy.

Biopsy ; Case-Control Studies ; Complement C3 ; analysis ; Glomerulonephritis, IGA ; blood ; diagnosis ; Humans ; Immunoglobulin A ; blood ; Kidney ; pathology

【Objective】 To investigate the characteristics of body fluid metabolic profile in patients with kidney stones based on surface-enhanced Raman spectroscopy, and to explore its application value and provide a reference for the screening of patients with kidney stones. 【Methods】 A total of 25 patients with kidney stones and 25 healthy controls were involved.Urine and blood samples were collected, whose spectra were measured with surface-enhanced Raman spectroscopy.The mean and difference spectra were plotted with origin software.The normalized data were processed with principal component analysis combined with linear discriminant analysis (PCA-LDA).Finally, the performance of the PCA-LDA method was evaluated with the receiver operating characteristic (ROC) curve. 【Results】 The levels of phosphatidylinositol, phenylalanine, palmitic acid/fatty acids, etc.in the urine of patients with kidney stones are higher than those in healthy controls, while the levels of components such as uracil and glycogen are lower.The content of methyl bands in the plasma of patients with kidney stones is higher than that of healthy controls, while the contents of glycogen, phosphatidylinositol, protein-tyrosine, phenylalanine, palmitic acid/fatty acid, hydroxyproline/tyrosine, and lipids are lower than those of healthy controls. 【Conclusion】 Surface-enhanced Raman spectroscopy can identify the changes in various metabolites in patients with kidney stones, and the combination of PCA-LDA and ROC analysis is helpful for the screening of patients.