Objective Observe and analyze the therapeutic effect of fluticasone propionate combined azithromycin on chronic si -nusitis after endoscopic sinus surgery .Methods 75 patients with chronic sinusitis and /or nasal polyps who treated with endoscopic surgery previously were selected in this study .All patients were divided into FP group ,cephalosporins group and combination group randomly .Each group contains 25 cases .CE group received cefradine ,FP group received FP while combination group using FP com -bined AZ treatment .The comparison was made in respects of symptom and nasal mucosa improvement ,clinical effect after 3 months .Results The symptom of patients in 3 groups all has improved after 3 months .Compare the improvement in 3 groups ,the CE group made the least improvement while the combination group made the best improvement which is also better than FP group (P< 0 .05) .The CE group made the least improvement while the combination group made the best improvement in aspect pf Endo -scopic score difference .After 3 months ,CE group has 60% entirely epithelization ,while FP group 84% and combination group 100% .Aftre 6 months ,the CE group has the lowest cure rate while the combination group has the highest cure rate (P< 0 .05) .And the recurrence rate in CE group was higher than the other two groups (P< 0 .05) .Conclusion Fluticasone propionate combined az-ithromycin on chronic sinusitis after endoscopic sinus surgery could improve the epithelization and clinical effect ,decrease the recur-rence rate .