1.Theoretical study of corresponding points for pain.
Lou BIDAN ; Ping GONG ; Wei ZHANG ; Jinxiang LI ; Jie HUANG ; Zhaoan YU
Chinese Acupuncture & Moxibustion 2015;35(1):77-79
The theoretical basis of "corresponding points" originates from opposing needling, contralateral needling and distal needling in acupuncture. It is to select points in corresponding area that is distant from diseased re gion to balance yin and yang and to activate meridians. Acupuncture at corresponding points, through reflex regu- lation of nervous system. could activate protective inhibition of cerebral cortex and cutoff of local malignant stimu lation, leading to quick elimination of pain. In clinic, it is mostly used for pain-related diseases.
Acupuncture Points
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Acupuncture Therapy
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Humans
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Medicine in Literature
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Pain Management
2.Acupoint selection for acupuncture analgesia based on the relationship of "the opening-closing- pivoting theory" with meridians and organs.
Chinese Acupuncture & Moxibustion 2018;38(5):5353-5358
"The opening-closing-pivoting theory" recorded in () visualizes the activity of six meridians and indicates the relationship among the six meridians in physiology and pathology. Through the analysis on the classic medical works and modern literature of TCM by the modern medical masters, a specific relationship is discovered among the hand and foot meridians of the same name and among the organs. The is corresponded and interacted among the hand and foot meridians of the same name. Except the exterior and interior relationship among the organs, the related communication is also existing. Both meridians and organs are closely related to "the opening-closing- pivoting" theory. This discovery is the inheritance and development of "the opening-closing-pivoting theory" and plays the important role in the guidance of the acupoint selection of clinical acupuncture analgesia.
Acupuncture Analgesia
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Acupuncture Points
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Humans
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Meridians
3.Long-term safety and efficacy of adalimumab for intestinal Behçet's disease in the open label study following a phase 3 clinical trial.
Nagamu INOUE ; Kiyonori KOBAYASHI ; Makoto NAGANUMA ; Fumihito HIRAI ; Morio OZAWA ; Dilek ARIKAN ; Bidan HUANG ; Anne M ROBINSON ; Roopal B THAKKAR ; Toshifumi HIBI
Intestinal Research 2017;15(3):395-401
BACKGROUND/AIMS: Intestinal Behçet's disease (BD) is an immune-mediated inflammatory disorder. We followed up the patients and evaluated safety profile and effectiveness of adalimumab for the treatment of intestinal BD through 100 weeks rolled over from the 52 week clinical trial (NCT01243671). METHODS: Patients initiated adalimumab therapy at 160 mg at week 0, followed by 80 mg at week 2, followed by 40 mg every other week until the end of the study. Long-term safety and all adverse events (AEs) were examined. The efficacy was assessed on the basis of marked improvement (MI) and complete remission (CR) using a composite efficacy index, which combined global gastrointestinal symptoms and endoscopic assessments. RESULTS: Twenty patients were enrolled in this study; 15 patients received adalimumab treatment until study completion. The incidence of AEs through week 100 was 544.4 events/100 person-years, which was comparable to the incidence through week 52 (560.4 events/100 person-years). No unexpected trend was observed and adalimumab was well tolerated. At weeks 52 and 100, 60.0% and 40.0% of patients showed MI, respectively, and 20.0% and 15.0% of patients showed CR, respectively. CONCLUSIONS: This report demonstrates 2 years safety and effectiveness of adalimumab in intestinal BD patients. Patients with intestinal BD refractory to conventional treatment receiving up to 2 years of adalimumab treatment demonstrated safety outcomes consistent with the known profile of adalimumab, and the treatment led to sustained reduction of clinical and endoscopic disease activity.
Adalimumab*
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Biological Products
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Endoscopy
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Humans
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Incidence
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Ulcer
4.Correlation of serum 25-(OH)D3 , albumin, ferritin with STAMP score and their predictive value for clinical outcome of preschool children with malnutrition
Jie SONG ; Linjuan HUANG ; Bidan GUO
Chinese Journal of Child Health Care 2024;32(1):39-44
【Objective】 To investigate the correlation of serum 25-hydroxyvitamin D
5.Leaky Gut Plays a Critical Role in the Pathophysiology of Autism in Mice by Activating the Lipopolysaccharide-Mediated Toll-Like Receptor 4-Myeloid Differentiation Factor 88-Nuclear Factor Kappa B Signaling Pathway.
Fang LI ; Haoran KE ; Siqi WANG ; Wei MAO ; Cexiong FU ; Xi CHEN ; Qingqing FU ; Xiaori QIN ; Yonghua HUANG ; Bidan LI ; Shibing LI ; Jingying XING ; Minhui WANG ; Wenlin DENG
Neuroscience Bulletin 2023;39(6):911-928
Increased intestinal barrier permeability, leaky gut, has been reported in patients with autism. However, its contribution to the development of autism has not been determined. We selected dextran sulfate sodium (DSS) to disrupt and metformin to repair the intestinal barrier in BTBR T+tf/J autistic mice to test this hypothesis. DSS treatment resulted in a decreased affinity for social proximity; however, autistic behaviors in mice were improved after the administration of metformin. We found an increased affinity for social proximity/social memory and decreased repetitive and anxiety-related behaviors. The concentration of lipopolysaccharides in blood decreased after the administration of metformin. The expression levels of the key molecules in the toll-like receptor 4 (TLR4)-myeloid differentiation factor 88 (MyD88)-nuclear factor kappa B (NF-κB) pathway and their downstream inflammatory cytokines in the cerebral cortex were both repressed. Thus, "leaky gut" could be a trigger for the development of autism via activation of the lipopolysaccharide-mediated TLR4-MyD88-NF-κB pathway.
Mice
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Animals
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NF-kappa B
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Myeloid Differentiation Factor 88/metabolism*
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Lipopolysaccharides/pharmacology*
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Toll-Like Receptor 4/metabolism*
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Autistic Disorder/metabolism*
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Signal Transduction/physiology*