Objective To detect human papilloma virus (HPV) and to determine its genotype in children with condyloma acuminatum (CA) in Weifang city,Shandong province.Methods Swab specimens were collected from the surface of lesions of 24 children with CA.PCR/flow-through hybridization assay was performed to detect HPV and determine its genotypes in these specimens.Results Among the 24 specimens,95.8％ (23/24) were positive for HPV.Of the HPV-positive specimens,87.0％ (20/23) harbored single type of HPV,and 13.0％ (3/23) multiple types of HPV.The most common genotype was HPV6(9/23),followed by HPV16 (6/23),HPV11 (5/23),HPV58 (3/23),HPV18 (2/23),and HPV53 (1/23).Conclusions HPV 6,16,11,58 and 18 prevail in children patients with CA in Weifang city,Shandong province.Additionally,the HPV genotypes in children patients are similar to those in their close contacts.

Triggering receptor expressed on myeloid cells-1 ( TREM-1 ) is one of immunoglobulin superfamilies found recently.TREM-1 is a crucial molecule for the triggering and amplification of inflammatory response and promote the reduction of in anti-inflammatory factor by crosslinking reaction with its ligand after being activated,or increasing the level of transcription factor.This study shows that TREM-1 may be claimed as a marker of infection,and the blockade of TREM-1 may be a new approach to inflammatory diseases.This study summarizes its structure,signal transduction,expression,accommodation and clinical application.

Objective To analyze quantitatively two-dimensional sonography of bladder cancer and clot with integrated backscatter(IBS) to evaluate its applied value in differential diagnosis of ladder cancer and clot.(Methods The IBS) and IBS% were measured in 32 patients with bladder cancer and 18 patients with bladder clot.(Results There were) significant differences of average image intensity(AII),peak to peak intensity(PPI) and standard deviation of image intensity(SDI) between bladder cancer and clot(P

Peanuts, corn and other food products are prone to aflatoxins (AF). AF was listed as a human carcinogen by the International Agency for Research on Cancer (IARC), especially aflatoxin B1 (AFB1), as it is considered the most prevalent and toxic. China is a big peanut producer, so carrying out pollution investigation and risk assessment in peanuts and their products is crucial to formulate prevention measures, protect export trade and maintain health. This paper summarizes the AF pollution of peanuts and their products in the Huang-Huai-Hai Basin, Yangtze River Basin, Southeast Coast and Northeast region of China from 2015 to 2021, and the application of dietary AF exposure risk assessment methods, providing a basis for strengthening the supervision of AF pollution in peanuts and their products, and ensuring food safety.

Objective To investigate the change of heart rate turbulence in patients with chronic heart failure and relationship to age、LVEF、LVED、heart rate before ventricular premature complex (VPC)、coupling interval、compensatory interval、the number and origin of VPC.Methods HRT was measured in 30 CHF patients and 30 healthy controls.HRT onset and slope were measured by the original definitions using Holter records and compared with the clinical factors.Results The HRT TS was significantly lower in patients wtih heart failure than in control (3.17?2.03vs9.64?6.47,P

Objective:To explore the diagnosis and treatment of small intestine leiomyosarcoma. Methods:Ten patients with small intestine leiomyosarcoma in Changhai Hospital from 1993 to 2001 were retrospectively analyzed. Results:Radical resection was performed in 6 cases with the shortest survival time being over 1 year and the longest being 8.5 years (still in good health). One case received extirpation operation with the survival time being over 4 years.Partial resection was performed in 3 cases,and the 3 patients died 1,2,3 years after operation respectively.Conclusion:The small intestine leiomyosarcoma is rare and its diagnosis is difficult due to the lack of clinical feature. Final diagnosis should be based on pathology.The disease is not very sensitive to radiotherapy and chemotherapy,which makes surgical treatment the choice.

[Objective]To investigate the related risk factors of unstable plaques in extracranial carotid arteries in patients with ischemic cerebrovascular diseases(ICVD).[Methods] Two hundred and eight ICVD patients were enrolled and plaques in extracranial carotid arteries were detected by c(a)rotid color ultrasound.All the patients were divided into unstable plaque group(75 cases)and stable plaque group (133 cases)according to the ultrasound performance.Related disease history and the traditional risk factors of ICVD were recorded.The risk factors with statistical significance were screened out by univariate nonconditional Logistic regression analysis,and then the independent risk factors of unstable plaques in extracnmial carotid arteries were analyzed by multivariate non-conditional Logistic regression analysis.[Results]Univariate non-conditional Logistic regression analysis showed that male,history of hypertension,history of diabetes,smoking were positively correlated with the formation of unstable plaques in extracranial carotid arteries(P＜0.01 or ＜0.05).High density lipoprotein cholesterol(HDL-C)was negatively correlated with the formation of unstable plaques in extracranial carotid arteries(P＜0.01).There were no statistical significance in history of coronary heart disease,law of life,family history of hypertension,drinking,family history of stroke and low density lipoprotein cholesterol between two groups(p ＞0.05).Multivariate non-conditional Logistic regression analysis showed that male,history of hypertension,history of diabetes and smoking were the independent risk factors of the formation of unstable plaques in ex tracranial carotid arteries (OR =2.33,7.16,6.15,2.28,respectively,P＜0.01).And HDL-C was the protection factor of the formation of unstable plaques in extracranial carotid arteries(OR=0.84,P ＜ 0.01).[Conclusions] The independent risk factors of the formation of unstable plaques in extracranial carotid arteries in patients with ICVD are male,history of hypertension,history of diabetes and smoking.And HDL-C is the protection factor of the formation of unstable plaques in extracranial carotid arteries in patients with ICVD.It has important significance to take out necessary intervention for patients with risk factors.

Objective To explore a best therapy regimen for conservative treatment of ectopic pregnancy.Methods Total of 124 cases of ectopic pregnancy underwent medicine therapy. They were divided into 4 groups: A group with MTX orly,B group with mifepristone only,C group with MTX and mifepristone comblnation,and D group with combined MTX, mifepristone and Traditional Chinese medicine (TCM). Results The curative rate was 80.65% ,61.29% ,87.10% and 90.32% in group A,group B,group C,and group D. The curative rate of group D is higher than other groups (P<0.05, P<0.01 ). Conclusion Combined MTX, mifepfistone and TCM has better effect on ectopic pregnany and has less side effects.

Objective To discuss the effect of music therapy on anxiety control of patients with maxillofacial cancer.Methods 140 cases in head and neck surgery department were divided into the test group and the control group with 70 cases in each group from March 2004 to November 2005.The test group received music intervention based on routine nursing.The degree of anxiety was evaluated on the first day of hospitalization(T1),the previous day before the operation(T2),the first day after operation(T3)and the third day after operation after listening to music.The control group only received routine nursing.The condition of anxiety at different time points was evaluated and compared.Results The scores of anxiety(SAS)in the two groups were statistically different(P＜0.05).The intra-group comparison of anxiety degree in the test group(T1-T2,T1-T3,T1-T4)had statistical difference(P＜0.05).The intra-group comparison of anxiety degree in the control group(T1-T2,T1-T3)had no statistical difference(P＞0.05).While evident difference existed in T1-T4 in the control group.P＜0.05.Conclusion Music intervention facilitated the rehabilitation of anxiety condition in cancer patients.