The research studied urinary beta2-microglobulin excretion to detect tubular dysfunction in 31 patients with primary nephrotic syndrome. The result showed the increased excretion of beta2-microglobulin was observed in 11/31 cases. There were no sighgicant differences of the urinary creatinine excreation and between group of patients with increased urinary beta2-microglobulin excretion and the group without it. This indicated having combine tubular dysfunction in patients with primary nephrotic syndrome. The finding might suggest the use of urinary beta2-microglobulin for detecting the associated tubular disfuntion in such patients
Diagnosis ; Creatinine ; Beta-Globulins

Analysis of synovial fluid is a most helpful aid in diagnosis and differentiating the varlous types of arthritis. But little information is available on joint fluid proteins and immunoglobullns. The present study was designed to obtain more precise information about each component of joint fluid proteins, using Acrylamide Gel Microzone system with a Densitometer. The following results were obtained: 1. The amount of total protein in both types of arthritis was approximately twice as high as that in the normal group (Normal;2.12± 0.50g%, R.A.;4.51± 1.18g%, Tbc;4.10± 1.02g%). 2. The albumin fraction was decreased in both types of arthrltis (R.A.;42.15± 5.21g%, Tbc; 44.24± 5.61g%) in comparison with 65.25± 4.40g% in the normal group. 3. The percentages of Alpha 1 and Beta globulin in both types of arthritis were similar to that in the normal group. (Normal:Alpha 1;6.01± 1.10, beta; 12.40± 1.90) 4. The percentages of Alpha 2 globulin and gamma globulin in both types of arthritis were approximately twice as high as that in the normal group. (Normal:Alpha 2;5.31± 1.62, Gamrna; 11.03± 1.51).
Acrylamide ; Arthritis ; Beta-Globulins ; Diagnosis ; gamma-Globulins ; Joints ; Synovial Fluid

Renal damage is one of the most common complications and cause of death in patients with multiple myeloma (MM). The studies have pointed out that early renal impairment is risk factor for progress of this disease, timely diagnosis and prompt intervention therapy are very important to improve the prognosis and survival of MM patients. Therefore, the diagnosis of early renal damage is crucial for clinical treatment. The progress on detection of early renal damage parameters and their value are reviewed in this article.
Alpha-Globulins ; urine ; Humans ; Kidney ; physiopathology ; Multiple Myeloma ; diagnosis ; physiopathology ; Proteinuria ; Retinol-Binding Proteins ; urine ; beta 2-Microglobulin ; urine

OBJECTIVETo investigate the renal function in newborns with birth asphyxia or intrauterine distress in the first week of life.

METHODSSixty full-term newborns born between June 2002 and February 2003 were assigned into three groups: Control group (healthy newborns), Intrauterine distress group (Apgar score > 7), and Birth asphyxia group without intrauterine distress (12 mild asphyxia and 8 severe asphyxia) (n=20 each). Urinary levels of alpha1-microglobulin (alpha1-MG), beta2-microglobulin (beta2-MG) and albumin (Alb) were detected by radioimmunoassay at 0-2, 3-4 and 6-7 days after birth.

RESULTSThe urinary levels of alpha1-MG, beta2-MG and Alb in the Asphyxia group were significantly higher than those in the Control group at all time points (P < 0.05), peaking at 3-4 days after birth. Statistically significant differences were found between the severely and mildly asphyxiated newborns for the urinary levels of alpha1-MG, beta2-MG and Alb at all time points (P < 0.05). There were no significant differences in the urinary levels of alpha1-MG, beta2-MG and Alb between the Intrauterine distress and the Control groups at each time point.

CONCLUSIONSBirth asphyxia may lead to renal glomerular and tubular impairments and it is speculated that the most serious impairment occurs at the 3rd and 4th days of life. The severity of renal impairments is associated with the degree of asphyxia. The renal function of the newborn appears to be normal following intrauterine distress.

Albuminuria ; urine ; Alpha-Globulins ; urine ; Asphyxia Neonatorum ; physiopathology ; Fetal Distress ; physiopathology ; Humans ; Infant, Newborn ; Kidney ; physiopathology ; beta 2-Microglobulin ; urine

OBJECTIVETo explore the effects of harmful factors in tank cabins on renal function of tank crews.

METHODSOne hundred and fifty two tank crews as the observation group and 37 soldiers without tank environment exposure as control group were selected in the study. α1-microglobulin(α1-MG), &beta;2-microglobulin(&beta;2-MG), IgG, N-acetyl-&beta;-glucosidase (NAG) and urinary albumin excretion rate (UAER) in morning and 24 h urine were measured.

RESULTSCompared to the control group, the levels of α1-MG, &beta;2-MG, NAG, UAER in observation group were increased significantly (P < 0.05). &beta;2-MG, NAG, UAER of Soldiers with more than 50 motorized hours in observation group were significantly higher than those of control group (P < 0.05). &beta;2-MG, NAG and UAER of soldiers divorced from tank occupation more than 3 years decreased to the normal levels. &beta;2-MG of soldiers divorced from tank occupation more than 10 years was significantly higher than that of 6-10 years group.

CONCLUSIONTank occupational exposure influences the renal function of tank crews but not to a degree of clinical kidney disease. The renal function of crews divorced from tank occupation may recover but dysfunction of renal tubular reabsorption still exists.

Acetylglucosaminidase ; metabolism ; Albuminuria ; Alpha-Globulins ; metabolism ; Environmental Exposure ; adverse effects ; Humans ; Kidney ; physiology ; Kidney Function Tests ; Military Personnel ; beta 2-Microglobulin ; metabolism

Many reports have been found in the literature regarding the electrophoretic study of various urogenital diseases, but those on syphilis are relatively rare. It is author's opinion that the correlation between syphilis and the dysfunction of various organs must also be elucidated into detail. On this view point the author has studied the total protein and paper electrophoretic fractions of the serum derived from the patients of syphilis in 17 males and 5 females visited our department during the period from October, 1962 to September, 1964 Age distribution was between 18 and 45 years of age and duration of history was from 3 months to 8 months. The results obtained were as follows: 1. Total protein and electrophoretic fractions of 22 patients' serum: a) The amount of total protein decreased slightly. b) Albumin decreased markedly. c) Alpha 1 globulin decreased remarkably. d) Alpha 2 globulin decreased slightly. e) Beta globulin increased very remarkably. f) Gamma globulin increased markedly. g) A/G ratio decreased very remarkably. All of the above patterns were compared with normal rate. 2. Total protein and electrophoretic fractions of same 22 patients' serum in duration 30 days after complete therapy: a) The amount of total protein, albumin alpha 2 globulin, gamma globulin and A/G ratio etc. are unchanged b) Alpha 1 globulin decreased markedly. c) Beta globulin increased slightly. All of the above pattern were compared with normal rate.
Age Distribution ; Beta-Globulins ; Electrophoresis, Paper ; Female ; gamma-Globulins ; Humans ; Male ; Syphilis

A Clinical observation on 272 cases of epidemic encephalitis admitted to the Department of Pediatrics, Chonnam University Hospital with 5 year duration from 1971 to 1975 was carried out and the serum protein fractions were studied paperelectrophoretically on 28 cases in 1975 The following results are obtained. : 1) The peak age group was from 6 to 10 years old, and the male to female ratio was 1.7:1 2) The complaints on admission were fever(100%), neck stiffness(78.3%), Kernig's sign(71.7%), vomiting(64.0%), unconsciousness(59.6%), and headache(57.4%), in order of frequency. 3) Laboratory findings were as follows ; In the most cases(79.4%), peripheral leukocytosis with increased polymorphocyte was noted. And the findings of C.S.F. showed; Pleocytosis (98.5%), increased protein content(90.1%), normal or slightly increased sugar content(97.8%) and within normal limits of chloride level. 4) Mortality rate was 20.2% 5) The total protein and beta-globulin level showed no change and decreased albumin and A/G ratio. The gamma-globulin level showed increased initially and thereafter decreased to normlal limits gradually.
Beta-Globulins ; Child ; Encephalitis, Arbovirus* ; Female ; gamma-Globulins ; Humans ; Jeollanam-do ; Leukocytosis ; Male ; Mortality ; Neck ; Pediatrics

The concentrations of serum proteins fractions and their electrophoretical patterns were investigated in 135 patients with coal workers' pneumoconiosis who participated in confirmative examination for pneumoconiosis in December 1989. Their radiographical profusions were classified as 1/0 or more. Agarose film and phosphoric acid-sodium hydroxide buffer(pH 8.6) were used for electrophoresis. Concentration of each protein fractions and electrophoretical patterns seemed to be equivalent to reference values. Serum alpah1- and beta-globulin concentrations, however, were significantly different(p<0.50) among categories of small opacity profusions and showed the lowest level in the group of category 1. Albumin concentrations decreased and alpha2-globulin concentrations increased significantly(p<0.05) in the group of complicated with pulmonary tuberculosis. gamma-globulin concentrations were not varied by category of profusions nor by pulmonary tuberculosis complication.
Beta-Globulins ; Blood Proteins ; Coal* ; Electrophoresis ; gamma-Globulins ; Humans ; Pneumoconiosis* ; Reference Values ; Sepharose ; Tuberculosis, Pulmonary

OBJECTIVE: To observe the characteristics of serum protein in patients with benign paroxysmal positional vertigo (BPPV) during the symptomatic period. METHOD: Fifty-five patients with BPPV and 58 control subjects were enrolled in the study. All the patients underwent the Dixe-Hallpike and Roll maneuver to confirm the type of BPPV. The average time of onset was (1.0 ± 0.8)days in the group of BPPV. The clinical features and the laboratory tests of serum protein electrophoresis, blood counts, and liver and kidney function were performed in both groups. RESULT: The levels of serum albumin (Alb), α1 globulin, α2 globulin and β globulin of BPPV group did not differ statistically in the two groups (P > 0.05); The γ-globulin levels were significantly higher in patients with BPPV than in controls (P < 0.05). CONCLUSION The γ-globulin levels are increased when BPPV is attacking.
Alpha-Globulins ; analysis ; Benign Paroxysmal Positional Vertigo ; blood ; diagnosis ; Beta-Globulins ; analysis ; Case-Control Studies ; Humans ; Serum Albumin ; analysis ; gamma-Globulins ; analysis

A hydrocele is a common condition which affects all age-group males including babies. It may be defined as a collection of serous fluid within the tunica vaginalis either surrounding the testis or along the spermatic cord or both. Congenital hydrocele is due to complete failure of the processus funicularis closure and most of the fluid collections subside spontaneously during the first year of life. The great majority of hydrocele are primary variety and its etiology is unknown. Secondary hydrocele may be developed to local injury, epididymitis and testicular neoplasms. Chronic hydrocele is common in tropical and subtropical countries where there is a high .incidence of filariasis. Some investigators have reported that hydrocele fluid collections are due to lymphatic defect or peritoneal fluid, It is generally known that hydrocele fluid resembles blood plasma. We performed electrophoresis and electrolytic analysis of hydrocele fluid and serum in 20 cases of hydrocele patients from January, 1981 to September, 1982. And then we obtained the statistical difference between hydrocele fluid and serum. The results are summarized as below: 1. Total protein of hydrocele fluid (4.125 gm/dl) is lower than that of serum (7,535 gm/dl). Statistical difference is greatly significant (p=below 0.005). 2. The proportion of albumin (71.780%) is higher than that of serum (65.685%). The proportion of alpha 2 and gamma globulin (6.880%, 5.535%) are lower than that of serum (10.125%, 8.730%). These statistical difference are greatly significant (p=below 0.005). 3. The proportion of alpha-1 and beta globulin (3.495%, 12.215%) are higher than that of serum (3.105%, 11.935%). There is no statistical significance (p=above 0.1). 4. Sugar of hydrocele fluid (87.65 mg/dl) is lower than that of serum (95.40 mg/dl), but there is no statistical significance (p=above 0.1). 5. Electrolytes of hydrocele fluid are lower than those of serum. Sodium (130 mEq/1); great statistical significance (p=below 0.005). Potassium (3.93 mEq/l); no statistical significance (p=above 0.1). Chloride (97.95 mEq/l); no statistical significance (p=above 0.1).
Ascitic Fluid ; Beta-Globulins ; Electrolytes* ; Electrophoresis ; Epididymitis ; Filariasis ; gamma-Globulins ; Humans ; Incidence ; Male ; Plasma ; Potassium ; Research Personnel ; Sodium ; Spermatic Cord ; Testicular Neoplasms ; Testis