Previous studies showed that whole body vibration could prevent bone resorption and stimulate new bone formation. The aim of this study is to detect and track effect of whole body vibration for osteoporotic bone of OVX rats. 12 Female rats were used and allocated into 5 group, CON, SHAM, WBV 17, WBV 30 and WBV 45. Rats except SHAM group were ovariectomised to induce osteoporosis. Rats in WBV groups were stimulated whole body vibration at magnitude of 1 mm(peak-peak) and frequency 17 Hz, 30 Hz and 45 Hz, repectively, for 8 weeks (20 min, 5 days/week). The 4th lumbar in rats were scanned at a resolution of 35 micrometer at baseline, before stimulation, and 8 weeks by In-vivo Micro-CT. To detect and track changes of morphological characteristics in lumbar trabecuar bone of rats, structural parameters were measured and calculated from acquiring images. In the results, changes of structural characteristics of WBV group were smaller than those of CON group. Loss of quantity of trabecular bone in WBV 45 was the least. In contrast, that in WBV 17 was the biggest. These results showed that reasonable whole body vibration beneficially affected osteoporotic bones. In addition to, whole body vibration was likely to be substituted partly for drug treatment.
Animals ; Bone Resorption ; Female ; Humans ; Osteogenesis ; Osteoporosis ; Rats* ; Vibration*

BACKGROUND AND OBJECTIVES: Cisplatin is frequently used in the treatment of various forms of malignancies. It's therapeutic efficacy, however, is limited due to the occurrence of sensorineural hearing loss. Little is known about the course of hearing loss after cessation of cisplatin administration. We observed the cochlear duct morphology with normal and cisplatin treated animals. MATERIALS AND METHODS: Healthy rats (strain Sprague-Dawly, weighting 80-100 mg) were used for all experiments. Total 15 rats were selected. They were divided into two groups, a treated group and a control. Four survival groups (n=3, respectively) were assigned as the treated group. After treatment with cisplatin, each survival group was sacrificed 1, 4, 10, 20 days. Except for the normal control (n=3), twelve animals were treated with cisplatin by daily I.P. injection of 1.5 mg/kg for 8 consecutive days. RESULTS: One day after cessation of cisplatin administration, outer hair cells (OHCs) loss and stria vascularis were degenerated especially in the basal turn. At 4, 10, 20 days, the OHCs and stria vascularis morphology of the survival group were similar to those of the survival group at one day. CONCLUSION: Our findings suggest cisplatin ototoxicity is predominantly involved in the basal turn of cochlear duct. This finding was significantly correlated with high frequency hearing loss of cisplatin ototoxicity.
Animals ; Cisplatin* ; Cochlear Duct ; Hair ; Hearing Loss ; Hearing Loss, Sensorineural ; Rats ; Stria Vascularis

BACKGROUND AND OBJECTIVES: The degree of noise induced hearing loss was determined principally according to the level and duration of noise and patient's state. The purpose of this study was to investigate the cochlear histopathology and hearing threshold immediately after noise exposure according to duration of noise exposure, and finally to draw relationship between the cochlear pathology and hearing threshold. MATERIALS AND METHOD: Each group of animals (6 ears) has been exposed for 10 minutes, 1 hour, 2 hours, 3 hours, 4 hours, 24 hours and 48 hours to an octave band of noise with a center frequency of 4000 Hz and a sound pressure level of 110 dB. After noise exposure, the hearing thresholds of the subjects were determined with auditory brainstem response (ABR) and immediately their inner ear were fixed and observed with transmission electron microscopy (TEM). RESULTS: ABR thresholds were increased according to lengthening of duration of noise exposure. TEM findings of outer hair cells, Deiters' cells and ganglion cells showed more severe degeneration according to lengthening of duration of noise exposure. Damages of all kinds of cells appeared almost at the same time. CONCLUSION: Through the foregone study, cochlear pathology was proportioned to increased hearing threshold, and the damages of outer hair cells and ganglion cells appeared almost at the same time. It seems that not only damages of outer hair cells, but also damages of ganglion cells contribute to early hearing threshold shift during continuous intense noise exposure.
Animals ; Cochlea* ; Ear, Inner ; Evoked Potentials, Auditory, Brain Stem ; Ganglion Cysts ; Hair ; Hearing Loss ; Hearing* ; Microscopy, Electron, Transmission ; Noise ; Pathology ; Rats*

BACKGROUND AND OBJECTIVES: Quinolone-induced arthropathy is an unusual toxic effect observed in juvenile animals of multiple species. Such toxic effects are usually found in joint cartilages. The reports of chondrotoxic potential of quinolones in juvenile animals were mainly performed in weight bearing joints such as hips and knees. The purpose of this study was to investigate the morphological changes in the incudomalleolar joint of immature rats dosed with ciprofloxacin, and to draw relationship between the incudomalleolar joint pathology and hearing. MATERIALS AND METHODS: An experimental group of 21-day-old rats were administrated intraperitoneally with 200 mg ciprofloxacin/kg for 10 days. The hearing threshs of the control and experimental animals were determined with auditory brainstem response (ABR). Their ossicles were obtained and fixed, and we observed them with light microscopy (LM) and transmission electron microscopy (TEM). RESULTS: The ABR threshs were increased in the ciprofloxacin administrated group, and the increased latency of the first waves were identified in the ciprofloxacin administrated group, but there were no differences in the interval of wave I-III. The LM findings of incudomalleolar joint in the ciprofloxacin administrated group showed cartilage lesions such as disrupted articilar surface, irregular cellularity of the chondrocytes, matrix swelling, cleft formation, decreased matrix staining. The TEM findings of the incudomalleolar joint cartilage in the ciprofloxacin administrated group showed decreased bundle-like matrix and cell process, condensed nucleus, and vacuolated cytoplasm. CONCLUSION: From the results of recent works and the present study, we suggest that ciprofloxacin may induce morphological changes in the incudomalleolar joint, and that such morphological changes may induce conductive hearing loss.
Animals ; Cartilage ; Chondrocytes ; Ciprofloxacin* ; Cytoplasm ; Evoked Potentials, Auditory, Brain Stem ; Hearing Loss, Conductive ; Hearing* ; Hip ; Joints* ; Knee ; Microscopy ; Microscopy, Electron, Transmission ; Pathology ; Quinolones ; Rats* ; Weight-Bearing

BACKGROUND AND OBJECTIVES: Deviation of the nasal septum toward one side is often associated with an outgrowth of the inferior turbinate, which occupies the expansive space of the contralateral nasal cavity. It is assumed that this contrabalanced mechanism characterized by compensatory hypertrophy has originated to protect the more patent nasal side from excessive airflow with its drying and crusting effect. We tried to investigate histologic differences of inferior turbinate mucosa of both sides in patients with nasal septal deviation. MATERIALS AND METHOD: Specimens were taken from the anterior portion of inferior turbinates of 15 patients with deviated nasal septum and compensatory hypertrophy of the inferior turbinate. After staining by hematoxylin-eosin, the histologic differences of bilateral turbinate mucosa were examined under light microscope. RESULTS: Epithelia of both sides showed normal or epithelial exfoliation. The number of submucosal glands was significantly higher in the opposite side than in the hypertrophied side. Inflammatory cell infiltration was more severe in the hypertrophied side than in the opposite side. CONCLUSION: Above results suggest that heavy infiltration of inflammatory cells and decreased number of glands in the hypertrophied side might result from aerodynamic change originated from difference of area of airway.
Humans ; Hypertrophy* ; Mucous Membrane ; Nasal Cavity ; Nasal Septum* ; Turbinates*

OBJECTIVE: The purpose of this study was to investigate the clinical feasibility of FDG-PET (Positron Emission Tomography) scan in patients with clinically no evidence of disease after treatment of cervical cancer. METHODS: One hundred and one patients with clinically NED(no evidence of disease) state after treatment of cervical cancer underwent PET scan. FDG-PET scan was obtained with a GE Advance Scanner, beginning at 50 minutes after injection of 370-555 MBq(10-15 mCi) of 18F FDG. Regional scan was also obtained with emission image. Uptake exceeding 3.0 SUV was determined as a positive finding. Recurrence was confirmed by CT, MRI, and needle biopsy if possible. RESULTS: Among 101 patients showing no evidence of disease, 17 patients(16.8%) showed abnormal PET scan findings. Clinically, 8 patients(7.9%) were confirmed to have recurrent lesion by CT, MRI or by needle biopsy. PET scan could detect recurrent lesions in the mediastinum or lung(10/17), pelvis(7/17), and supraclavicular lymph node(2/17). The sensitivity and specificity of PET scan in patients with cervical cancer showing no evidence of disease were 100% and 90.3%, respectively. The positive predictive value, negative predictive value and false positive rate were 47.1%, 100% and 52.9%. CONCLUSION: PET scan could detect 7.9% of early recurrence in patients with cervical cancer with NED status. FDG-PET scan may be a useful method in detecting metastases or recurrence of a cervical cancer showing no evidence of disease by routine conventional imaging studies.
Biopsy, Needle ; Humans ; Magnetic Resonance Imaging ; Mediastinum ; Neoplasm Metastasis ; Positron-Emission Tomography ; Recurrence ; Sensitivity and Specificity ; Uterine Cervical Neoplasms*

There were few studies about anatomic characteristics in Korean humerus recently. In addition, there was no comparison between Westerner (European and American) and Korean in anatomic characteristics of humerus. The aims of this paper are therefore to investigate anatomic characteristics in Korean humerus and to compare them with those of Westerner humerus. The seventy-two humerus (male : 66, female : 6) were scanned by computed tomography and three dimensional (3D) models of humerus were then reconstructed from acquired cross-section images. The twenty-one anatomic characteristics of the humerus were analyzed and were measured for each humerus. From the results, humeral head vertical diameter in the present study was generally bigger than that in the previous study (p<0.05). There was no significant difference between the anatomic characteristics of the right and left humerus in the present Korean (p>0.05). Humeral head inclination angle, greater tuberosity lateral offset distance, humeral head height in Korean were generally bigger than those in Westerner (p<0.05). This study may contribute to develop an optimal implants and prostheses for the treatment of humerus fractures of Koran.
Female ; Humans ; Humeral Head ; Humerus ; Prostheses and Implants

Adenomyoma is a benign tumor composed of smooth muscle and benign endometrium. These tumors typically originate within the uterus. An extrauterine adenomyoma is a rare entity. Cystic degeneration of adenomyoma is also very rare case. We report a case of huge extrauterine endometrioid-type adenomyoma with cystic change with brief review of literature.
Adenomyoma ; Endometrium ; Female ; Muscle, Smooth ; Uterus

Granulosa cell tumors of ovary are rare neoplasms, which account for 2~5% of all ovarian malignancies. Ovarian granulosa cell tumors are often associated with endometrial hyperplasia or carcinoma. The endometrial carcinoma is thought to occur under the influence of the estrogen receptor pathway and is typically a low-grade endometrioid adenocarcinoma. We present a case of granulosa cell tumor of the ovary and synchronous endometrial carcinoma that were managed with laparoscopically assisted vaginal hysterectomy and bilateral salpingo-oophorectomy, with brief review of literature.
Adult ; Carcinoma, Endometrioid ; Endometrial Hyperplasia ; Endometrial Neoplasms ; Estrogens ; Female ; Granulosa Cell Tumor ; Granulosa Cells ; Humans ; Hysterectomy, Vaginal ; Laparoscopy ; Ovary

Sclerosing stromal tumor (SST) is an uncommon benign tumor of the ovary, representing 2~6% of all stromal ovarian tumors. It is a distinct benign neoplasm that differs from fibromas, thecomas, luteinized tumors and steroid cell tumors. It presents most often with non-specific symptoms and tumor markers usually remain normal. However massive ascites is a rare symptom. We report a case of sclerosing stromal tumor with massive ascites and elevated CA 125 with brief review of literature.
Ascites ; Female ; Fibroma ; Lutein ; Ovary ; Thecoma ; Biomarkers, Tumor