Introduction: Acne vulgaris is a common dermatologic disorder caused by follicular epidermal hyperproliferation, excess se- bum production, inflammation, and Cutibacterium acnes (C. acnes). The mangosteen fruit rind contains large amount of xantho- nes, which has high antimicrobial activity against C. acnes. Objectives: To compare the efficacy and safety of mangosteen 1% extract gel versus benzoyl peroxide (BPO) 5% gel in the treat- ment of mild to moderate acne vulgaris. Methods A total of 60 participants with mild to moderate acne or a rating of 2 or 3 in the Investigator’s Global Assessment (IGA) for acne were randomized to receive either mangosteen 1% extract gel or BPO 5% gel applied on the face twice daily over an 8-week period. Primary outcomes measured in the study were clinical remission graded as “clear” or “almost clear” (rating of 0 or 1) based on the IGA and any adverse reaction.
Acne Vulgaris ; Benzoyl Peroxide

INTRODUCTION

Acne vulgaris is a common skin condition caused by various factors within the pilosebaceous unit. Propolis, a sticky, brown, and fragrant resinous material made by bees, has antibacterial and anti-inflammatory properties and can help address some of the pathogenesis of acne vulgaris.

To compare the efficacy and safety of propolis 10% cream versus benzoyl peroxide (BPO) 5% cream on mild to moderate acne vulgaris.

The study included 46 participants with mild to moderate acne or Investigator’s Global Assessment (IGA) grade 2 or 3, randomized to receive propolis 10% or BPO 5% cream twice daily for 8 weeks. Primary outcomes were IGA success rates (score of 0 or 1), 50% lesion reduction, adverse reactions, and quality of life changes measured by the DLQI.

The study found that the success rate was 15% in the propolis group and 9% in the BPO group. In clinical response, 25% of patients in the propolis group and 52.38% in the benzoyl peroxide (BPO) group showed improvement in inflammatory lesions. For non-inflammatory lesions, 5% of patients in the propolis group demonstrated improvement, compared to 28.57% in the BPO group (p=0.538). 5% of the propolis group reported itching and burning, while 9.52% of the BPO group reported scaling (p=0.1806). Both groups showed significant decreases in DLQI scores from baseline to the fourth follow-up.

Topical propolis 10% cream can be an alternative acne treatment, given its comparable effect to BPO and its excellent safety profile.

Introduction: The researchers aimed to determine the efficacy of tea tree oil in comparison to benzoyl peroxide in treating mild acne. This study also aimed to identify the side effects of both treatment modalities. Methods: Using a randomized single blinded controlled clinical trial, teenagers and young adults with mild acne vulgaris were allocated to receive tea tree oil gel or benzoyl peroxide for four weeks. The effectiveness of the agents was measured using the Investigator's Global Assessment Scale. Posttreatment scores were compared with the baseline within groups. The difference was compared between the two study arms. Adverse reactions to the two agents were also noted. Results : Both tea tree oil and benzoyl peroxide groups showed a significant decrease in the posttreatment lesion counts compared to the baseline, however when the mean differences were compared between groups, the difference was not significant. Conclusion Tea tree oil is comparable to benzoyl peroxide in treating mild acne vulgaris among teenagers and young adults.
Tea Tree Oil ; Benzoyl Peroxide

BACKGROUND: The efficacy and safety of daily maintenance treatment with an adapalene-benzoyl peroxide (adapalene-BPO) fixed-dose combination gel is established in acne vulgaris in adults. OBJECTIVE: This study evaluated the efficacy and tolerability of twice-per-week maintenance therapy with an adapalene-BPO combination gel for acne vulgaris in adults. METHODS: All patients applied the adapalene-BPO combination gel once daily during the initial 8 weeks. Subsequently, the patients were randomized into two groups. The maintenance group applied the ointment twice-per-week for 12 weeks of maintenance treatment, while the control group discontinued treatment after the initial 8 weeks active treatment. The changes in the mean numbers of total, inflammatory, and non-inflammatory lesions were assessed. RESULTS: During maintenance treatment, the changes in the average numbers of total and inflammatory lesions in the maintenance group differed significantly from the control group. CONCLUSION: Twice-per-week application of an adapalene-BPO combination gel after active treatment appears to be a good option for the maintenance therapy of acne vulgaris in adults.
Acne Vulgaris* ; Adult* ; Benzoyl Peroxide ; Humans ; Adapalene

BACKGROUND: An antibiotic-free, fixed-dose combination gel with adapalene (A) 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for treatment of acne vulgaris. OBJECTIVE: To compare the clinical outcomes of A-BPO combination gel with vehicle gel for treatment or maintenance therapy of patients with acne vulgaris. METHODS: An electronic search of the database PubMed (1966 to September 2012), Embase (1984 to September 2012), and Cochrane Controlled Trials Register (CENTRAL; 3rd Quarter, 2012) was undertaken to identify relevant studies. Main clinical outcomes were success rate, treatment-related adverse events (AEs), AEs leading to discontinuation, satisfaction with the effectiveness, and overall satisfaction. RESULTS: Six studies were finally included in this meta-analysis. The A-BPO group yielded better clinical outcomes regarding the success rate (p<0.00001), satisfaction with the effectiveness of treatment (p=0.005), and overall satisfaction (p=0.005) compared to the vehicle group. The incidence of treatment-related AEs in the A-BPO group was comparable with that of vehicle group (p=0.09), while the A-BPO group was associated with a slightly increase in the incidence of AEs leading to discontinuation when compared with the vehicle group (p=0.02). CONCLUSION: A-BPO combination gel yields better clinical outcomes including success rate, satisfaction with the effectiveness, and overall satisfaction compared to vehicle gel, despite an increased incidence of AEs leading to discontinuation. The A-BPO combination agent most likely contributes to the treatment of moderate acne vulgaris rather than severe acne vulgaris, but it may be useful in maintenance therapy of patients with severe acne vulgaris.
Acne Vulgaris* ; Benzoyl Peroxide ; Humans ; Incidence ; Adapalene

BACKGROUND

Acne vulgaris is a common skin disorder among adolescents and young adults, with a worldwide prevalence of 9.4%. Both 5% dapsone gel and 5% benzoyl peroxide gel (BPO) have been reported in literature to have antimicrobial action against Cutibacterium acnes.

To compare the efficacy and safety of 5% dapsone gel versus 5% BPO gel in Filipino patients with mild to moderate acne vulgaris in a tertiary hospital.

Phase 1 involved compounding 5% dapsone gel and assessing its safety in healthy individuals through a repeated open application test in 30 participants. In phase 2, a double- blinded experimental study compared the efficacy and safety of both groups. Participants were randomized through block design. Efficacy and safety was assessed using the Global Acne Assessment Score (GAAS) and lesion count, and monitoring the adverse effects. The Cardiff Acne Disability Index (CADI) questionnaire was utilized to evaluate the impact on quality of life.

In phase 1, 56.7% of the participants were female and the only reported adverse event was pruritus (13.3%). In phase 2, both the BPO and dapsone group had 35 participants enrolled. Most are female (75.7%) with a mean age of 24. Results showed improvement in the GAAS from moderate to mild, a decrease in inflammatory and non-inflammatory lesions, and a reduction in side effects during the succeeding visits in both groups.

5% dapsone gel and 5% BPO were both efficacious and safe for mild to moderate acne management.

BACKGROUND: A fixed-dose combination gel with adapalene 0.1% and benzoyl peroxide (BPO) 2.5% has been developed for once-daily treatment of acne. It is known to be effective to reduce inflammatory and non-inflammatory lesions, but there have been no study in Korean yet. OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of adapalene 0.1%-BPO 2.5% fixed-dose combination gel (adapalene-BPO) for the treatment of mild to moderate severity acne in Korean. METHODS: In total, 64 patients with mild to moderate severity acne were enrolled. Adapalene-BPO was applied to face once daily at night. The efficacy assessment was performed at baseline and monthly for 3 months: inflammatory lesions (IL), non-inflammatory lesions (NIL), total lesions (TL) were counted and median percentage changes of each lesion were measured for 3 months with patient satisfaction and adverse events questionnaire. RESULTS: Of the 64 patients enrolled, 58 have completed 3-month treatments. Adapalene-BPO showed early onset of action with significant reduction in inflammatory, non-inflammatory, and total lesion counts. The median percentage reduction of mild group from baseline to 3rd month was greater than moderate group in IL, NIL, and TL counts (71.1% vs 65%/61.4% vs 56.4%/67.7% vs 62% reduction). Also, patient satisfaction score improved and significant reduction of Korea Acne Grading System (KAGS) was noted in both groups. All the reported adverse events were mild. CONCLUSION: This study shows that adapalene-BPO is an effective and safe treatment regimen for both mild and moderate acne. It has a better effect for treating mild severity acne than moderate acne with reduction of the IL, NIL, and TL counts and greater patient satisfaction.
Acne Vulgaris ; Benzoyl Peroxide ; Humans ; Korea ; Naphthalenes ; Patient Satisfaction ; Adapalene

BACKGROUND: While adapalene and benzoyl peroxide have both been demonstrated to be effective for the treatment of acne vulgaris, they can also cause skin irritation, resulting in patient incompliance. In addition, the irritation may be severe when adapalene is co-administered with benzoyl peroxide. OBJECTIVE: The intention of this study was to evaluate the efficacy and safety of adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel, and adapalene 0.1% gel monotherapy, for the treatment of mild to moderate acne. Any changes in the skin barrier function were also measured. METHODS: A total of 52 patients applied adapalene-benzoyl peroxide gel or adapalene gel once daily. The changes in lesion counts, investigator's global assessment, patient satisfaction, and adverse events were recorded for 6 weeks. The biophysical profiles of the skin, including transepidermal water loss and redness, were measured for 3 weeks. RESULTS: Both agents were effective for the treatment of acne lesions. Adapalene-benzoyl peroxide showed a faster onset of action than adapalene, especially on inflammatory lesions. However, at week 6, both agents showed a similar effect in reducing lesion counts. While most patients in both groups experienced skin irritation from week 1, this gradually reduced. Likewise, the changes in transepidermal water loss and redness showed peak rates at week 1 and 2, but decreased over time. CONCLUSION: Adapalene-benzoyl peroxide gel is effective for the treatment of acne with a safety profile comparable to adapalene gel. The skin irritation experienced may be associated with the changes in skin barrier disruption, which lasts for 1~2 weeks.
Acne Vulgaris* ; Benzoyl Peroxide ; Humans ; Intention ; Patient Satisfaction ; Skin* ; Adapalene

In order to evaluate the effect of zinc sulfate on acne vulgaris, this study was performed during 3 months' period from October, 1979 to December 31, 1979. Total number of acne patients visited at the Department of Dermatology, Han Gang Sung Shim Hospital were 130, but among them 58 patients had completed this atudy. The patients were classified in 3 groups, A, B, C, as follows. Group A (23 patients) who were treated with zinc sulfate (600mg/day) and 2. 5% benzoyl peroxide Group B (20 patients) who were treated with tetracycline (initial: 750mg/day, after 2weeks: 500rng/day) and 2. 5% benzoyl peroxide. Group C (15 patients) who were treated with only 2. 5% benzoyl peroxide. To evaluate the efficacy of treatment in these 3 groups, the number of open comedone, closed comedone, papule and pustule were counted every other week for 8 weeks. (countiuned..)
Acne Vulgaris ; Benzoyl Peroxide ; Dermatology ; Humans ; Tetracycline ; Zinc Sulfate* ; Zinc*

Benzoyl peroxide has been known to have bacteriostatic activity against Corynebacterium acnes and to have comedolytic action in patients with acne vulgaris. The present study was undertaken to evaluate the therapeutic effect of Renoxal, a 5% benzoyl peroxide lotion, in patients with acne vulgaris. A total of 35 patients entered this study at the Department of Dermatology, Seoul National University Hospital during the five months period from March to July, 1978. All patients were instructed to apply Benoxal on their affected sites once or twice daily; and the number of lesions on three fixed areas were counted before and every week for four weeks after the treatrnent. Two female patients stopped the application due to developrnent of contact dermatitis to Benoxal The results observed in the 33 patients were as follows: 1. The percentage decrease in total number of lesions in four weeks after treatment was 51.1% 2. Closed and open comedones were gradually eliminated; and their numbers were decreased in four weeks after treatment by 45. 8% and 55. 3% respectively. The papules were decreased. by 59. 1 @2 after the first week of treatment, but showed. a transient lag around tbe second week and then marked 61. 5% in four weeks after treatment. 3. Observed side effects included burning sensation,(3 cases), tightness (3 cases), itching sensation (2 cases) and scaling (1 case). All were tolerable without any specific measure or discontinuance of the application. The authors concluded througb this experiment that Benoxal (5% benzoyl peroxide lotion) is a very effective local therapeutic agent in the treatment of acne vulgaris patients.
Acne Vulgaris* ; Benzoyl Peroxide ; Burns ; Dermatitis, Contact ; Dermatology ; Female ; Humans ; Propionibacterium acnes ; Pruritus ; Sensation ; Seoul ; Thiram