Objective:To establish a headspace capillary gas chromatography method for the determination of residual solvents in clindamycin hydrochloride. Methods:A headspace gas chromatography was used to separate the residual solvents on a DB-624 capillary column with an FID detector. The carried gas was nitrogen at a flow rate of 2ml·min-1 . The split ratio was 1∶1. The temperature of the injector was 200℃ and that of the FID was 300℃. The programmed column temperature was set as follows:maintained at 40℃ for 5 min and then raised to 200℃ at the rate of 20℃·min-1 and maintained for 10 min. The containers of headspace injector were in e-quilibrium at 80℃ for 30 min. Water was used as the solvent. The amounts of the residual solvents such as methanol,ethanol,acetone, chloroform and N,N-dimethyformamide were calculated by an external standard method. Results:The detected solvents were separated completely. The calibration curve of each solvent showed a good linear relationship (r=0. 999 1 ~0. 999 9). The average recovery was within the range of 97. 2% ~101. 2% and RSD was within the range of 0. 68% ~1. 98%(n=9). Conclusion:The method is suit-able for the determination of residual solvents in clindamycin hydrochloride.

The aerosol of biodegradable multi-function film was prepared by means of two-step methods, and its properties were investigated. The average loading capacity was 4.8603 g; the average leaking rate was 3.03% per year which was less than 5%. And the average ejecting rate was 0.7380 g/s. The results demonstrate that the aerosol of biodegradable multi-function film has met the principles governing the quality of the aerosols.
Aerosols ; chemical synthesis ; Biocompatible Materials ; Biodegradation, Environmental ; Biomechanical Phenomena ; Lactic Acid ; chemistry ; Materials Testing ; Membranes, Artificial ; Polyesters ; Polyglycolic Acid ; chemistry ; Polymers ; chemistry

The aerosol of biodegradable multi-function film were prepared, whose properties, affective factors and hemostasis effect were studied. Film formation properties were investigated in different lots of aerosols, including film formation time, uniformity, film particle size and film thickness. Young's modulus was about 0. 0373GPa, and elongation at break was 0. 89% by means of tensile method. It is proved that the aerosol of biodegradable multi-function film is easy to form films and its hemostasis effect is well.
Aerosols ; chemical synthesis ; Animals ; Biocompatible Materials ; therapeutic use ; Biodegradation, Environmental ; Hemostasis, Surgical ; methods ; Hemostatics ; administration & dosage ; Male ; Membranes, Artificial ; Particle Size ; Random Allocation ; Rats ; Rats, Wistar