CD40 pathway plays an important role in occurrence and development of acute and chronic allograft rejection.Further research on immune characteristics of CD40 pathway will explore new field for investigation of early monitoring,prevention and control of rejection.sCD30 as the active component of CD30 activation and release into blood has good correlation with CD30.Expression of CD30 provides a high sensitive and specific non-traumatic examination method for early diagnosis of acute rejection and its identification with acute tubular necrosis in renal transplantation.It also provides the basis for immunosuppressive therapy after transplantation.Through the above research on factor associated with renal transplant rejection,the rejection can be effectively predicted and prevented,transplantation immunoreaction can be solved,successful rate of renal transplantation will be increased,and long-term survival of graft will be improved.