1.Galbulimima bark and ethnomedicine in Papua New Guinea.
Papua and New Guinea medical journal 2006;49(1-2):57-9
This article reviews the literature and current information on the use of Galbulimima bark in traditional medicine in Papua New Guinea. Galbulimima bark is used in Papua New Guinea as an analgesic, to treat fever or to get rid of head lice. It is used in divination to produce trance-like states for counteracting malevolent power that is thought to be the cause of a variety of illnesses. Galbulimima bark has also been chewed, or drunk as a decoction, to induce visions and a dream-like state. It is also chewed and then rubbed on the legs before fighting.
Papua New Guinea
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Ethnomedicine
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seconds
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Fighting
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Alcoholic beverage heavy drinker
2.Cannabis in Papua New Guinea.
Papua and New Guinea medical journal 2006;49(1-2):52-6
Cannabis is the most commonly used illicit drug in Papua New Guinea (PNG). Data on the epidemiology and history of cannabis in PNG are presented. The adverse health consequences of cannabis smoking and treatment options for cannabis dependence are discussed. It is recommended that a range of strategies are urgently required in PNG to prevent adverse physical and mental health consequences associated with cannabis smoking.
Cannabis
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Papua New Guinea
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Smoking
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Study of epidemiology
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treatment options
3.Renal cell carcinoma bony metastasis treatment.
Saminathan Suresh NATHAN ; Chin Tat LIM ; Benjamin Y S CHUAH ; Thomas C PUTTI ; Anthony J STANLEY ; Alvin S C WONG
Annals of the Academy of Medicine, Singapore 2008;37(3):247-248
Bone Neoplasms
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diagnosis
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secondary
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Carcinoma, Renal Cell
;
diagnosis
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secondary
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Humans
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Kidney Neoplasms
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pathology
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Male
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Middle Aged
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Patella
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Sternum
4.Lack of Current Recommendations for Resuming Sexual Activity Following Spinal Surgery
Cara Michelle THOMAS ; Howard Benjamin LEVENE
Asian Spine Journal 2019;13(3):515-518
Patients are faced with many questions surrounding the after effects of the various surgical procedures and their ability to return to preoperative activities. While patients often question whether surgery would provide alleviation of pain, weakness, and instability, they often have additional questions about sexual activity during their convalescence that are not always addressed. Although the literature shows postsurgical improvement in sexual activity in association with improved low back pain, reports vaguely address the variability in sexual activity recommendations based on anatomic location and type of spinal surgery. We conducted a PubMed search of the English language from 1990 to 2018 with the following keywords: sexual activity, postoperative, spinal fusion, spinal decompression, functional outcomes, laminectomy, rehabilitation, biomechanics, lumbar disc surgery, metabolic energy expenditure, coital position, and Oswestry Disability Index. Additional studies are needed that survey both patients and spine surgeons to examine current recommendations and to help formulate future guidelines.
Bariatric Surgery
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Convalescence
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Decompression
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Energy Metabolism
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Humans
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Laminectomy
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Low Back Pain
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Rehabilitation
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Sexual Behavior
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Spinal Fusion
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Spine
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Surgeons
5.Outcomes after robot-assisted laparoscopic radical prostatectomy.
Declan G MURPHY ; Benjamin J CHALLACOMBE ; Anthony J COSTELLO
Asian Journal of Andrology 2009;11(1):94-99
Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical system is now in widespread use in many countries where economic conditions allow the installation of this expensive technology. Controversy has surrounded the procedure since it was first performed in 2000, with many critics highlighting the lack of evidence to support its use. However, despite the lack of level I evidence, many large studies of patients have confirmed that the procedure is feasible and safe, with low morbidity. Available longer-term oncological data seem to show that outcomes from the robotic approach at least match those of traditional open radical prostatectomy. Functional outcomes also seem satisfactory, although randomized controlled trials are lacking. This paper reviews the current status of RALRP with respect to perioperative data and complications and oncologic and functional outcomes.
Erectile Dysfunction
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etiology
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Humans
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Laparoscopy
;
methods
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trends
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Male
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Prostatectomy
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adverse effects
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instrumentation
;
methods
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Prostatic Neoplasms
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surgery
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Robotics
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methods
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trends
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Treatment Outcome
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Urinary Incontinence
;
etiology
6.18F-FDG PET/CT Imaging of Peritoneal Fibrosis Mimicking Persistent Metastatic Ovarian Carcinoma
Benjamin LEROY-FRESCHINI ; Véronique LINDNER ; Thomas BOISRAMÉ ; Martin DEMARCHI
Korean Journal of Nuclear Medicine 2020;54(5):249-251
A 65-year-old woman was addressed for clinical and biological suspicion of ovarian cancer relapse. 18F-FDG PET/CT revealed massive peritoneal carcinomatosis. Post-chemotherapy PET/CT showed complete metabolic response in initial localizations albeit three new 18F-FDG uptakes appeared in the mesentery and in the retro-hepatic space. Close follow-up (including PET/ CT scan) and surgical examination of the abdominal cavity confirmed the absence of malignancy and the benign nature of these lesions, which appeared to be peritoneal fibrosis mimicking persistent carcinomatosis.
7.In vitro Stability of Heat Shock Protein 27 in Serum and Plasma Under Different Pre-analytical Conditions: Implications for Large-Scale Clinical Studies.
Matthias ZIMMERMANN ; Denise TRAXLER ; Elisabeth SIMADER ; Christine BEKOS ; Benjamin DIEPLINGER ; Mitja LAINSCAK ; Hendrik Jan ANKERSMIT ; Thomas MUELLER
Annals of Laboratory Medicine 2016;36(4):353-357
The effects of storage temperatures, repeated freeze-thaw cycles, or delays in separating plasma or serum from blood samples are largely unknown for heat shock protein 27 (HSP27). We evaluated (1) the imprecision of the HSP27 assay used in this study; (2) the in vitro stability of HSP27 in blood samples stored at 4℃ for up to 6 hr with immediate and delayed serum/plasma separation from cells; and (3) the in vitro stability of HSP27 in blood samples stored at -80℃ after repeated freeze-thaw cycles. The ELISA to detect HSP27 in this study showed a within-run CV of <9% and a total CV of <15%. After 4-6 hr of storage at 4℃, HSP27 concentrations remained stable when using serum tubes irrespective of sample handling, but HSP27 concentrations decreased by 25-45% when using EDTA plasma tubes. Compared with baseline HSP27, one freeze-thaw cycle had no effect on serum concentrations. However, plasma concentrations increased by 3.1-fold after one freeze-thaw cycle and by 7.3-fold after five freeze-thaw cycles. In conclusion, serum is an appropriate biological sample type for use in epidemiological and large-scale clinical studies.
*Enzyme-Linked Immunosorbent Assay
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Freezing
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HSP27 Heat-Shock Proteins/*blood
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Humans
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Protein Stability
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Reproducibility of Results
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Specimen Handling
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Temperature
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Time Factors
8.Antibiotic Spacers in Shoulder Arthroplasty: Comparison of Stemmed and Stemless Implants.
Eric M PADEGIMAS ; Alexia NARZIKUL ; Cassandra LAWRENCE ; Benjamin A HENDY ; Joseph A ABBOUD ; Matthew L RAMSEY ; Gerald R WILLIAMS ; Surena NAMDARI
Clinics in Orthopedic Surgery 2017;9(4):489-496
BACKGROUND: Antibiotic spacers in shoulder periprosthetic joint infection deliver antibiotics locally and provide temporary stability. The purpose of this study was to evaluate differences between stemmed and stemless spacers. METHODS: All spacers placed from 2011 to 2013 were identified. Stemless spacers were made by creating a spherical ball of cement placed in the joint space. Stemmed spacers had some portion in the humeral canal. Operative time, complications, reimplantation, reinfection, and range of motion were analyzed. RESULTS: There were 37 spacers placed: 22 were stemless and 15 were stemmed. The stemless spacer population was older (70.9 ± 7.8 years vs. 62.8 ± 8.4 years, p = 0.006). The groups had a similar percentage of each gender (stemless group, 45% male vs. stemmed group, 40% male; p = 0.742), body mass index (stemless group, 29.1 ± 6.4 kg/m² vs. stemmed group, 31.5 ± 8.3 kg/m²; p = 0.354) and Charlson Comorbidity Index (stemless group, 4.2 ± 1.2 vs. stemmed group, 4.2 ± 1.7; p = 0.958). Operative time was similar (stemless group, 127.5 ± 37.1 minutes vs. stemmed group, 130.5 ± 39.4 minutes). Two stemless group patients had self-resolving radial nerve palsies. Within the stemless group, 15 of 22 (68.2%) underwent reimplantation with 14 of 15 having forward elevation of 109°± 23°. Within the stemmed group, 12 of 15 (80.0%, p = 0.427) underwent reimplantation with 8 of 12 having forward elevation of 94°± 43° (range, 30° to 150°; p = 0.300). Two stemmed group patients had axillary nerve palsies, one of which self-resolved but the other did not. One patient sustained dislocation of reverse shoulder arthroplasty after reimplantation. One stemless group patient required an open reduction and glenosphere exchange of dislocated reverse shoulder arthroplasty at 6 weeks after reimplantation. CONCLUSIONS: Stemmed and stemless spacers had similar clinical outcomes. When analyzing all antibiotic spacers, over 70% were converted to revision arthroplasties. The results of this study do not suggest superiority of either stemmed or stemless antibiotic spacers.
Anti-Bacterial Agents
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Arthroplasty*
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Body Mass Index
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Comorbidity
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Dislocations
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Humans
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Joints
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Male
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Operative Time
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Paralysis
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Prosthesis-Related Infections
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Radial Nerve
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Range of Motion, Articular
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Replantation
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Shoulder*
9.Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth in bone in a murine xenograft model.
Thomas M BODENSTINE ; Benjamin H BECK ; Xuemei CAO ; Leah M COOK ; Aimen ISMAIL ; Should J Kent POWERS ; J Kent POWERS ; Andrea M MASTRO ; Danny R WELCH
Chinese Journal of Cancer 2011;30(3):189-196
The bones are the most common sites of breast cancer metastasis. Upon arrival within the bone microenvironment, breast cancer cells coordinate the activities of stromal cells, resulting in an increase in osteoclast activity and bone matrix degradation. In late stages of bone metastasis, breast cancer cells induce apoptosis in osteoblasts, which further exacerbates bone loss. However, in early stages, breast cancer cells induce osteoblasts to secrete inflammatory cytokines purported to drive tumor progression. To more thoroughly evaluate the role of osteoblasts in early stages of breast cancer metastasis to the bones, we used green fluorescent protein-labeled human breast cancer cell lines MDA-MB-231 and MDA-MB-435, which both induce osteolysis after intra-femoral injection in athymic mice, and the murine pre-osteoblastic cell line MC3T3-E1 to modulate osteoblast populations at the sites of breast cancer metastasis. Breast cancer cells were injected directly into the femur with or without equal numbers of MC3T3-E1 cells. Tumors grew significantly larger when co-injected with breast cancer cells and MC3T3-E1 cells than injected with breast cancer cells alone. Osteolysis was induced in both groups, indicating that MC3T3-E1 cells did not block the ability of breast cancer cells to cause bone destruction. MC3T3-E1 cells promoted tumor growth out of the bone into the extraosseous stroma. These data suggest that breast cancer cells and osteoblasts communicate during early stages of bone metastasis and promote tumor growth.
Animals
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Bone Neoplasms
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secondary
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Breast Neoplasms
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pathology
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Cell Line
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Cell Line, Tumor
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Disease Models, Animal
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Female
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Femur
;
pathology
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Humans
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Mice
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Mice, Nude
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Neoplasm Transplantation
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Osteoblasts
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cytology
;
physiology
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Osteolysis
;
etiology
;
Tumor Burden
10.Local Signs and Symptoms in Spontaneous Cervical Artery Dissection: A Single Centre Cohort Study
Lukas MAYER ; Christian BOEHME ; Thomas TOELL ; Benjamin DEJAKUM ; Johann WILLEIT ; Christoph SCHMIDAUER ; Klaus BEREK ; Christian SIEDENTOPF ; Elke Ruth GIZEWSKI ; Gudrun RATZINGER ; Stefan KIECHL ; Michael KNOFLACH
Journal of Stroke 2019;21(1):112-115
No abstract available.
Arteries
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Cohort Studies