MicroRNA is a class of non-protein coding,single-stranded small RNAs of 22-25 nucleotides length.It takes part in many physiological processes including tumorigenesis.In the present focus studies,molecular biology and bioinformatics methods are used to study the role of miRNA in tumors.Several miRNAs with research value have been found and their mechanisms have been investigated in endometrial carcinoma.Results from the studis provide valid evidence for further research.

High mobility group box-1 (HMGBI)is a kind of non-histone chromatin-binding protein in nucleus.HMGB1 is intimately associated with the regulation of transcription,inflammation and rheumatic disease through binding the receptor.Recently,HMGB1 is overexpressed in several malignant tumors,and the expression level is positively correlated with the degree of differentiation,tumor invasion and metastasis.HMGB1 may be a new target molecule of antitumor.