Objective:To perform a statistical analysis of the ABO blood group distribution of COVID-19 convalescents, and further analyze the ABO blood group distribution in COVID-19 convalescents with different plasma antibody titer against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Methods:Convalescent plasma was collected from 150 patients aged 18-60 years old who had recovered from COVID-19. Convalescent plasma was collected 14 days later after patients discharged from hospital, and another 180 normal people in Wuhan city were served as healthy control group. Then we analyzed the relationship between age, gender and the ABO blood group distribution. We also tried to clarify the relationship between plasma antibody liter against SARS-CoV-2 and the ABO blood group distribution.Results:Compared with the healthy control group, the proportion of blood group B in COVID-19 convalescents was higher (36% vs 25.0%, χ 2=4.714, P<0.05). The ABO blood group distribution did not differ from male and female COVID-19 convalescents, while age affected the ABO blood group distribution of COVID-19 convalescents. Among the age group under 40 years old, the proportion of blood group B in COVID-19 convalescents was higher than that in the healthy control group (38.5% vs 25.0%, χ 2=5.264, P<0.05). The antibody titer against SARS-CoV-2 in 5.3% of the convalescent plasma was under 1:80. In the high antibody liter against SARS-CoV-2 group, the proportion of blood group B in COVID-19 convalescents was higher than that in the healthy control group (35.2% vs 25.0%, χ 2=3.979, P<0.05). Conclusions:COVID-19 convalescents with blood group B and age group under 40 years old have a higher proportions than that in the normal people. Part of the convalescents with lowantibody liter against SARS-CoV-2 didn’t meet the conditions for plasma donation. Convalescents with blood group B may be more suitable as plasma donators for the therapy of COVID-19.