Objective To explore the effect of actively vascular catheters management via a professional team with clinical nurse specialist as the core among patients receiving chemo-radiotherapy. Methods Totally 762 tumor patients with chemo-radiotherapy in Sihucan cancer hospital were selected as the research object by convenient sampling method. 300 patients from January to December 2014 was taken as the control group ( patients received routine management ) and 462 patients from January to December 2015 was taken as the experimental group (patients received professional management with clinical nurse specialist as the core). The incidences of complications and indwelling time in two groups were compared and analyzed by independent-samples T test and chi-square test.Results There were 11 cases of thrombus, 13 cases of tube plugging and 16 cases of phlebitis in the control group, while there were 5 cases of thrombus, 3 cases of tube plugging and 8 cases of phlebitis in the experimental group. The incidences of thrombus, tube plugging and phlebitis in the experimental group were obviously lower than those in the control group (χ2=4.676,12.009,8.876;P<0.05). There were 8 cases of unplanned extubations in the control group, but none in the experimental group. The indwelling time of central venous catheter (CVC) and peripherally inserted central catheter (PICC) were (21.2± 11.5) d and (55.8±26.3) d in the control group, while they were (25.6±13.1)d and (63.8±22.1)d in the experimental group (t=-2.57,-2.97;P<0.01).Conclusions The actively vascular catheters management via a professional team with clinical nurse specialist as the core among patients receiving chemo-radiotherapy, is likely to reduce some complications after intravenous indwelling catheter, and avoid unplanned extubation and extend the indwelling time.