ObjectiveTo observe the effects of nasal continuous positive airway pressure(NCPAP) on neonatal respiratory disease.Methods67 newborns with respiratory disease undergone the treatment of NCPAP and routine clinic treatment.The changes of blood gas index and therapeutic effects were observed.The changes of blood gas between the pretherapy and post-treatment were compared.ResultsThe numerus of PaO2,SpO2 was increased apparently at 1 hour after treament with NCPAP.The difference was significant ( t =3.84,15.50,all P ＜ 0.05 ).But the PaCO2 had no apparent change and the difference was not significant(t =1.96,P ＞ 0.05 ).54 newborns were treated successfully and 13 newborns were treated unsuccessfully.51 newborns were cured,11 newborns were improved and 1 patient was dead at Last.ConclusionThe early application of NCPAP on neonatal respiratory disease was very effective.It could reduce the use of mechanial ventilation,and it was a convenient,safe and effect-prominent method.

AIM:To observe the effect of parenteral nutrition(PN)in the feeding of premature infants.METHODS:Seventy five premature infants were randomly assigned into three groups.The control group supplied glucose combined with minimal enteral nutrition and assisted with nonutrition sucking.In treatment groups:the no-fat emulsion PN group supplied amino acids and glucose combined with minimal enteral nutrition and assisted with nonutrition sucking,and the fat emulsion PN group supplied fat emulsion,amino acids and glucose combined with minimal enteral nutrition and assisted with nonutrition sucking.After 1 week,the weight,the state correlated biochemical indicator and complications were detected.RESULTS:Both of the no-fat emulsion PN therapy and the fat emulsion PN therapy could promote weight gain and lessen complications,and the clinical application was comparatively safe.CONCLUSION:The PN can improve growth and development of premature infants and elevate the clinical therapeutic efficacy.

AIM:To observe the neuroprotection effects exogenous adrenomedullin(AM) against hypoxic-ischemia reperfusion damage(HIRBD) in neonatal rat models.METHODS:Forty neonatal rats were randomly divided into Control Group(n=8,with sham operation),Hypoxic-ischemia Reperfusion(HIR) Group and Intervention Group(n=8,wth intraperitoneal AM injection 0,6 and 12 h after making model).All rats were decapitated at 48 hours after reperfusion,and the cerebral slices were made at the 2 mm level in front of the interaural line.The pathobiological changes of brain tissue were observed by the method of HE dye in light microscope,and the levels of nitrogen monoxide synthase(NOS),glutathion(GSH) and myeloperoxidase(MPO) in neonatal rats cerebral tissue were determined by using chromatometry.RESULTS:Hypoxic-ischemia reperfusion could induce obviously cerebral pathological change which could be improved by AM.The brain tissue levels of cNOS and GSH in AM 0 and 6 h Group were significantly higher than those of HIR Group(P