OBJECTIVETo study the relations of noise expose and hypertension in mechanic factory workers.

METHODSA cross-sectional study on 1205 workers (exposed to different noise levels) in Hunan was carried out, using questionnaire, blood pressure of the workers and the exposure level to noise at workplace.

RESULTSThe prevalence of hypertension was 12.1% in mechanic factory workers. There was an increasing tendency of hypertension rate along with the increase of accumulative noise doses (tendency chi-squared = 29.932, P < 0.01). Result by logistic regression analysis after adjusting age, history of hypertension in parents and body weight index showed that the risk of hypertension increased about 5% by 1 dB(A) of more noise exposure (OR = 1.047).

CONCLUSIONNoise exposure might serve as a risk factor of hypertension. Reducing the sound pressure level in workshops could work as an effective measure to control the incidence rate of hypertension in mechanic factory workers.

Adult ; Demography ; Female ; Humans ; Hypertension ; epidemiology ; etiology ; prevention & control ; Logistic Models ; Male ; Middle Aged ; Noise ; adverse effects ; Occupational Exposure ; adverse effects ; statistics & numerical data ; Risk Factors ; Surveys and Questionnaires

OBJECTIVETo evaluate the efficacy and toxicity of the combined therapy with oxaliplatin and capecitabine (XELOX) in patients with advanced or recurrent gastric cancer.

METHODSForty-one patients with previously untreated advanced or recurrent gastric cancer received intravenous infusion of oxaliplatin at the dose of 130 mg/m(2) on day 1 and oral administration of capecitabine at 1000 mg/m(2) twice a day on days 1-14. The chemotherapy was repeated every 2 weeks for a median of 4 cycles.

RESULTSTwo of 41 patients achieved a complete response, and 15 had partial responses, with an overall response rate of 41.5%. Stable disease was observed in 11 patients and progressive disease in 9. The median time to progression and overall survival was 6.2 months and 11.8 months. All the 41 patients were evaluated for toxicity according to NCI criteria, 4 showed grade 3-4 neural toxicity, 4 had hematological toxicity and 3 had hand-foot syndrome.

CONCLUSIONThe XELOX regimen shows good efficacy with an acceptable toxicity profile in advanced or recurrent gastric cancer patient.

Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols ; therapeutic use ; Deoxycytidine ; analogs & derivatives ; therapeutic use ; Female ; Fluorouracil ; analogs & derivatives ; therapeutic use ; Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local ; drug therapy ; Stomach Neoplasms ; drug therapy ; pathology

OBJECTIVE: To determine the status and influence factors of hypertension on mechanic factory workers and to provide reference for further hypertension prevention and control. METHODS: A cross-sectional study on 1205 workers (exposed to different noise levels) in Hunan was carried out by using questionaire and measuring the blood pressure of the workers and the noise exposure level in the workplace. The prevalence and the influence factors of hypertension among mechanic factory workers were analysed. RESULTS: The hypertension prevalence was 12.1%. Logistic regression analysis showed the body weight index (BMI), age, and history of hypertension in parents and accumulative noise dose levels influenced the hypertension prevalence. CONCLUSION Controlling the body weight, reducing alcohol consumption, decreasing the sound pressure level in workshops and advocating healthy diet may reduce the prevalence rate of hypertension among mechanic factory workers.
Adult ; Body Weight ; China ; epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Hypertension ; epidemiology ; etiology ; Logistic Models ; Male ; Mechanics ; Middle Aged ; Noise, Occupational ; adverse effects ; Prevalence ; Risk Factors ; Surveys and Questionnaires

OBJECTIVETo study on mechanisms of acupuncture in relieving visceral pain.

METHODSIn SD rats CRD was used as noxious visceral stimuli. Activities of spinal dorsal horn wide dynamic (WDR) neurons of L1-L13 were recorded by extracellular microelectrode technique. Acupuncture was given at ipsi-lateral and contra-lateral Zusanli (ST 36) of the same segmental innervation of rectum and colon.

RESULTSVisceral noxious afferent could significantly activate spinal dorsal horn convergent neurons, and mechanical stimulation of contra-lateral body surface and hand acupuncture at Zusanli (ST 36) could inhibit this noxious response. When the spinal cord was acutely blocked, the inhibiting CRD effect of needling CRD effect of needling contra-lateral Zusanli (ST 36) completely disappeared.

CONCLUSIONAcupuncture and visceral noxious afferent signals converge and interact each other in spinal level, and acupuncture at acupoint can inhibit the spinal dorsal horn neuron respon se activated by visceral noxious afferent and this action needs the participation of the center above the spinal cord.

Animals ; Colon ; innervation ; Nociceptors ; Posterior Horn Cells ; Rats, Sprague-Dawley ; Rectum ; Spinal Cord

OBJECTIVETo establish the HPLC fingerprint of Xuelian injection.

METHODHPLC with Diamonsil C18 (4.6 mm x 250 mm, 5 microm) column was used, the methanol-1% acetic acid as a mobile phase and detection wavelength at 270 nm.

RESULTIndicating 11 peaks on HPLC fingerprint.

CONCLUSIONThis method is simple and acurate with a good reproducibility and can be used as a quality control method for Xuelian injection.

Chromatography, High Pressure Liquid ; methods ; Drugs, Chinese Herbal ; administration & dosage ; chemistry ; isolation & purification ; Injections ; Plants, Medicinal ; chemistry ; Quality Control ; Saussurea ; chemistry

Cerebral Palsy ; metabolism ; Child ; Child, Preschool ; Female ; Gas Chromatography-Mass Spectrometry ; Humans ; Infant ; Infant, Newborn ; Male ; Metabolism, Inborn Errors ; diagnosis ; genetics

OBJECTIVETo investigate the antitumor activity of Diosgenin in vivo and in vitro.

METHODS-180, HepA, U14 and EAC transplant mice were given Diosgenin ig or i.p. everyday for 10 days, from the next day when they were inoculated in axilla. Tumor growth inhibit rates were calculated. Four kinds of cells, MCF, L929, A375-S2 and HeLa, were incubated respectively with Diosgenin in vitro. Tumor growth inhibit rates were also calculated.

RESULTIn vivo, both ig and i.p., Diosgenin inhibited S-180, HepA, U 14 mice transplant tumor, the inhibit rates being 30%-50%, but it did not inhibit the EAC mice transplant tumor. In vitro, Diosgenin inhibited L929, HeLa, MCF cell growth, and IC50 were 1.2, 18.2, 19.8 micrograms.mL-1 respectively, but it did not significantly affect A375-S2 cells.

CONCLUSIONDiosgenin has an obvious antitumor activity on S-180, HepA, U14 transplant mice in vivo and L929, HeLa, MCF cells in vitro.

Animals ; Antineoplastic Agents, Phytogenic ; therapeutic use ; Carcinoma, Ehrlich Tumor ; drug therapy ; Dioscorea ; chemistry ; Diosgenin ; isolation & purification ; therapeutic use ; Female ; Humans ; Inhibitory Concentration 50 ; Male ; Mice ; Neoplasm Transplantation ; Phytotherapy ; Plants, Medicinal ; chemistry ; Sarcoma 180 ; drug therapy ; Tumor Cells, Cultured ; drug effects

OBJECTIVETo observe the clinical effect and security of Sanqi Tongshu capsule in treating ischemic strkoe.

METHODA multicenter, no dummy, open labeled clincal trail was conducted. 1 753 patient were enrolled in this clinical trial. All patients were treated with the Sanqi Tongshu capsule (200 mg, three times a day) for 28 days. The score of Europe Stroke Score (ESS) and Barthel Index (BI) were evaluated before and after treatment. The adverse reaction occurred in the therapeutic course was also observed.

RESULTFinally, 1742 cases and 1676 cases were respectively assessable by Full analysis set (FAS) analysis and Full analysis set (FAS) analysis. Clinical symptoms markedly improved in patients after treatment, and the score of ESS and BI had significantly improved (P<0.05). According to the score of ESS and BI, the total effect analysis indicated that the total effective rate in FAS and PPS were 81.86% and 84.43% respectively. The rate of adverse reaction was 3.44%, and the raction was so slight that didn't need to receive therapy or withdral drug.

CONCLUSIONSanqi Tongshu capsule is effect and secure in treating ischemic stroke without obvious adverse reaction.

Aged ; Drugs, Chinese Herbal ; adverse effects ; therapeutic use ; Female ; Humans ; Male ; Stroke ; drug therapy ; pathology ; Treatment Outcome

OBJECTIVETo evaluate the role and application of flow cytometry in the diagnosis of non-Hodgkin lymphoma (NHL).

METHODSFresh cell samples from 40 cases of lymphoproliferative disorders were obtained by fine needle aspiration or excisional biopsies. Multiparameter flow cytometry was used to study the surface antigens of lymphoid cells. The immunophenotyping results were also correlated with morphologic features seen in the cytology preparations.

RESULTSOf the 40 cases with histologic diagnosis of NHL, 37 cases (92.5%) had the lymphoma diagnosis confirmed by this method. The concordance rate for the 20 cases of B-cell NHL was 100%. As for the 17 cases with histologic diagnosis of T-cell NHL, 12 cases (66.7%) were correctly diagnosed as T-cell NHL using flow cytometry, while 2 cases (11.8%) were interpreted as B-cell NHL and the remaining 3 cases (17.6%) were undiagnosed.

CONCLUSIONImmunophenotyping by flow cytometry can serve as an ancillary technique in diagnosis and subclassification of NHL.

Adolescent ; Adult ; Aged ; Biopsy, Fine-Needle ; Female ; Flow Cytometry ; methods ; Humans ; Immunophenotyping ; Lymphoma, B-Cell ; diagnosis ; immunology ; pathology ; Lymphoma, Non-Hodgkin ; diagnosis ; immunology ; pathology ; Lymphoma, T-Cell ; diagnosis ; immunology ; pathology ; Male ; Middle Aged ; Reproducibility of Results ; Sensitivity and Specificity

Objective To evaluate the epidemiological effects of vaccine immunization program related to A(H1N1)influenza in the middle school students.Methods Non-randomized clinical trial was designed to assess the A(H1N1)influenza vaccine on its efficacy.14883 students from 8 middle schools in Zhejiang province were recruited and classified into vaccinated or control groups,based on the status of immunization with A(H1N1)influenza vaccine.All subjects were followed up through one epidemic period(6 months)and the incidence rates of influenza-like illnesses,A(H1N1)influenza,and seasonal influenza in these two groups were compared to evaluate the efficacy of the vaccine.Results There were 6334 subjects in the vaccinated group and 8549 in the control group.7441.75 person-years were followed from these two groups.The incidence rate of A (H1N1)influenza in vaccinated group was 1.64‰ per person-year,lower than that of the control group.The rate difference(RD)was-1.64‰ per person-year(95% confidence interval value from-3.04‰ to-0.23‰ per person-year),and the difference was significant(P=0.010).The incidence rate of influenza-like illnesses in vaccinated group was 21.47‰ per person-year,lower than that of the control group(22.69‰ per person-year)and the diffefence was not significant(P>0.05).The incidence rate of B influenza in vaccinated group was 6.63‰ per person-year,higher than that of control group(7.02‰ per person-year)but the difference was not significant(P>0.05).Conclusion This vaccine demonstrated a good epidemiological effect against the A(H1N1)influenza virus infection,observed through a student-immunization program.The cross-protection effect against the influenza-like illnesses and other seasonal influenzas was not noticed in this study.