Objective To observe the clinical effects of patients with Bullous Pemphigoid by improved extracting blister fluid and wiping ointments nursing. Methods A total of 28 patients were randomly divided into observational group (n=14) and control group (n=14). All the patients were treated with common therapy. For patients in the observational group, they used improved extracting blister fluid combined with wiping ointments nursing, while patients of the control group underwent extracting blister fluid combined with wiping ointments by themselves. The curative effects were compared between two groups. Results The period of no new blisters, periods of blisters drying and reducing incretion to half amount in observation group were shorter than these in the control group (P<0. 05). Conclusions Therapy of extracting blister fluid combined with wiping ointments nursing can promote the blister to heal, relieve pain, reduce incidence of infection and length of disease progress.

Objective To investigate the mediating role of physical activity and negative psychological state be-tween sleep quality and cognitive function in stroke patients.Methods A total of 119 patients who were admitted and di-agnosed with acute ischemic stroke(AIS)in Zibo Central Hospital from January 2021 to December 2022 were selected,and a self-made scale was used to conduct a questionnaire survey.A Pearson correlation analysis was used to investigate the correlation of physical activity and negative emotions with sleep quality and cognitive function,and the hierarchical re-gression method was used to investigate the mediating role of physical activity and negative emotions.Results The 117 patients had a Pittsburgh Sleep Quality Index of(8.39±1.20).There were significant differences between the two groups in sex,age,physical activity score,Hospital Anxiety and Depression Scale score,and Montreal Cognitive Assessment Scale score(P<0.05).The Pearson correlation analysis showed that sleep quality score was negatively correlated with physical activity score and cognitive function score(r=-0.677 and-0.750,P<0.001)and was positively correlated with negative emotion score(r=0.585,P<0.001).The hierarchical regression analysis showed that physical activity and nega-tive emotions had a mediating role between sleep quality and cognitive function(P<0.05).Conclusion AIS patients have poor sleep quality after 30 days.There is a good correlation between sleep quality and physical activity/negative emo-tions/cognitive function,and physical activity and negative emotions plays a mediating role between sleep quality and cogni-tive function.