7.Progress in biochemical characteristics of hemopexin and its clinical application.
Bei-Bei DONG ; Fang-Yun ZHU ; Hai-Dong WEI ; Hai-Long DONG ; Li-Ze XIONG
Journal of Experimental Hematology 2013;21(2):513-516
Hemopexin (HPX) is a plasma protein with the strongest binding capacity to heme and widely involved in modulation of a variety of physiological and pathological processes. The main physiological function of HPX is to bind and transport free toxic heme. Recent studies indicate that HPX also plays roles of anti-oxidant, anti-apoptosis, immune regulation and organic protection. In addition, HPX participates in regulation of cell differentiation and extracellular matrix reconstruction. In recent years, a great deal of progress has been made in studies of the mechanisms of HPX protective effects and on possible clinical application. In the past few years, especially, a number of proteomic studies have demonstrated that HPX could be served as positive molecular biomarkers for cancers of lung, liver, kidney, colon, and uterine myoma as well as osteoarthritis. In this review, recent progress in the biochemical characteristics and function of HPX and its possible clinical applications are summarized.
Heme
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Heme Oxygenase (Decyclizing)
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Hemopexin
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chemistry
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metabolism
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Humans
8.Ideas and methods for treatment of gastrointestinal diseases by integrated Chinese and Western medicine.
Tuan-Jie QI ; Bei-Hai WEI ; Zhi-Shui CHEN
Chinese Journal of Integrated Traditional and Western Medicine 2009;29(5):444-449
The fundamental mechanism of gastrointestinal diseases is the imbalance between the attack factor and the protective factor of stomach mucous membrane. It can not outbreak if the protective factor is stronger than the attack factor; otherwise, it will. Attack and protective function inside the stomach are mediated by various factors. These related factors interaction constitutes a complicated network system. This kind of outbreak theories of imbalance in Western medicine is same as that, "The sense of right saves inside, the evil can't do" and "Evil is competing with right, all diseases occur", in Chinese medicine. So, it is the key which points to futher study the interaction between gastrointestinal attack factors and protective factors by traditional Chinese medicine, thus improving the clinical effect.
Gastrointestinal Diseases
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therapy
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Humans
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Integrative Medicine
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Medicine, Chinese Traditional
10.Evaluation of the correlation between cerebral blood volume and permeability surface from CT perfusion images with glioma grade
Bei DING ; Hua-Wei LING ; Huan ZHANG ; Qi SONG ; Hai-Peng DONG ; Ke-Min CHEN ;
Chinese Journal of Radiology 2001;0(01):-
Objective To evaluate the correlation between cerebral blood volume and permeability surface by using muhislice CT perfusion imaging with glioma grade.Methods Ninteen patients with gliomas underwent conventional MR and multislice CT perfusion imaging preoperatively.These patients were divided into low grade and high grade groups which were correspond to WHO Ⅱ grade gliomas and WHO Ⅲ or Ⅳ grade gliomas respectively.CT data were transferred to on-line working station and processed to obtain time-signal curves,color perfusion maps and calculated perfusion parameters,including cerebral blood volume(CBV),cerebral blood flow(CBF),mean transit time(MTT)and permeability surfaces (PS)in tumoral parenchyma.Kruskal-Wallis test and correlation of CBV and PS was assessed by using SPSS 11.0 software.Results The median of CBV and PS in low-grade and high-grade glioma were 2.7, 6.5 ml/100 g;0.389,12.810 ml?100 g~(-1)?min~(-1),respectively,corresponding t value were 12.907, 13.500 with P