OBJECTIVE To study the differences of gastric receptivity and emptying function of functional dyspepsia(FD) patients with different syndromes by liquid nutrient load test combined with B ultrasound examination.METHODS Seventy four subjects were included,which included 14 healthy cases(HS group),60 FD patients(33 cases of spleen deficiency and qi stagnation,16 cases of spleen deficiency and dampness accumulation,11 cases of spleen yang deficiency).Liquid nutrient load-ing test was performed for all subjects,and the threshold and maximum intake were recorded combined with VAS visual score. Gastric emptying rate and half emptying time of patients with different syndromes were compared by ultrasonic measurement. RESULTS The maximum intakes of three syndromes in FD group were lower than that in the HS group(P<0.05~0.01), and the maximum intake of spleen deficiency and dampness accumulation syndrome was lower than those of spleen deficiency and qi stagnation syndrome and spleen yang syndrome(P<0.05).Compared three syndromes in FD group with HS group, distal gastric emptying rate of postprandial 90min of spleen yang deficiency syndrome was lower than that of HS group(P<0.05).distal gastric emptying time of spleen deficiency and dampness accumulation syndrome was longer than that of spleen deficiency and qi stagnation syndrome and spleen yang deficiency syndrome in HS group(P<0.05).CONCLUSIONS There is difference in gastrointestinal motility between FD patients with the same syndrome,and that of the patients with spleen defi-ciency and dampness accumulation syndrome decreased more significant,which provides theoretical basis for TCM syndrome differentiation and treatment.

Coptidis Rhizoma-Evodia Fructus is a classic herb pair in traditional Chinese medicine prescriptions, the famous prescription is called Zuojinwan, which comes from Danxi Xinfa, is composed of Coptidis Rhizoma-Evodia Fructus (6∶1). In this formula, Coptidis Rhizoma has the effect of clearing heat and drying diuresis, purging fire to remove toxin and clearing heart. Evodia Fructus has the effects of expelling cold and alleviating pain, checking upward adverse flow of Qi tostop vomiting, and assisting yang to stop diarrhea. Coptidis Rhizoma has the properties of bitter and cold, and Evodia Fructus has the properties of pungent and calidus. Pungent drugs have divergent effects, and bitter drugs have sedimentation effect, when used in combination, they can clear the liver and purge fire, calm the adverse-rising energy and stop vomiting. On the basis of Zuojinwan, Coptidis Rhizoma-Evodia Fructus medicine has derived different compatibility ratios. Different ratios are different in terms of efficacy, usage, clinical application. Although with the application of modern analytical instruments and the development of molecular pharmacology theory, the chemical constituents and Pharmacological effects of Coptidis Rhizoma and Evodia Fructus have been fully studied, as to the principle of compatibility, and the study of pharmacological effects and chemical constituents after the compatibility of the two drugs in different proportions, there is still no comprehensive system summary. This article makes a systematic and comprehensive explanation of Coptidis Rhizoma-Evodia Fructus from the aspects of famous literature, chemical composition, pharmacological effects and clinical applicationthrough querying literature and ancient books. In order to make this herb pair more standardized, and provide reference materials for further research and development for this herb pair.