1.The Clinical Feature of Behcet's Disease in Northeastern China.
Yingbin SHANG ; Shixin HAN ; Jiuhong LI ; Qiushi REN ; Fangji SONG ; Hongduo CHEN
Yonsei Medical Journal 2009;50(5):630-636
PURPOSE: Behcet's disease (BD) is a chronic, relapsing, multi-system vasculitis of unknown aetiology with complicated and diversified clinical features predominantly involving oral and genital ulcers, and ocular and cutaneous lesions. The clinical features of this disease have been described to be different according to geographical areas and gender. We investigated the specific clinical features of BD patients in Northeastern China. MATERIALS AND METHODS: 116 patients involved in this study fulfilled the classification criteria of the International Study Group for BD. The clinical manifestations and results of laboratory tests of BD were recorded in each patient. RESULTS: The onset was typically between 20-39 years with a slight female predominance. Oral ulcers were the most common manifestation, followed by skin lesions, positive pathergy reaction/genital ulcers, and ocular lesions. Vascular lesion and epididymitis were rare in patients with BD. The frequency of erythema nodosum-like lesion and articular involvement were significantly higher in females, while gastrointestinal involvement was significantly higher in males. The results of laboratory tests showed that the human leukocyte antigen (HLA)-B*51 alleles were positive in 30.9% of patients and the immunological abnormities were present in some patients. CONCLUSION: The clinical features of BD showed geographical and gender difference. Genetic and immune factors might participate in aetiopathogenesis of BD.
Behcet Syndrome/*diagnosis/epidemiology/pathology
;
China
;
Female
;
Geography
;
Humans
;
Male
2.Renal Manifestations in 2007 Korean Patients with Behcet's Disease.
Sung Bin CHO ; Jihyun KIM ; Shin Wook KANG ; Tae Hyun YOO ; Zhenlong ZHENG ; Suhyun CHO ; Hye Sun LEE ; Dongsik BANG
Yonsei Medical Journal 2013;54(1):189-196
PURPOSE: Behcet's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels. MATERIALS AND METHODS: A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD. RESULTS: Among the 2007 BD patients, we noted hematuria in 412 (20.5%) and proteinuria in 29 (1.4%). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies. CONCLUSION: We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.
Adolescent
;
Adult
;
Age Factors
;
Aged
;
Aged, 80 and over
;
Behcet Syndrome/*complications/epidemiology/*metabolism
;
Biopsy
;
Female
;
Glomerulonephritis, IGA/complications/diagnosis
;
Hematuria/complications/diagnosis
;
Humans
;
Kidney/*pathology
;
Kidney Diseases/*diagnosis
;
Logistic Models
;
Male
;
Middle Aged
;
Multivariate Analysis
;
Proteinuria/complications/diagnosis
;
Republic of Korea
;
Young Adult