1.Carpal Tunnel Syndrome in Behcet's Disease.
Jungsoo LEE ; Suhyun CHO ; Do Young KIM ; Zhenlong ZHENG ; Hoon PARK ; Dongsik BANG
Yonsei Medical Journal 2015;56(4):1015-1020
PURPOSE: Behcet's disease (BD) is a chronic inflammatory disease characterized by orogenital ulcers, skin and ocular lesions, in addition to articular, vascular, and neurologic symptoms. Carpal tunnel syndrome (CTS), can also occur in BD patients secondary to inflammation in the connective tissues, vessels, and tendons, as well as nerve involvement in BD itself. However, reports of patients who have CTS in BD are rare. The aim of this study was to evaluate the clinical characteristics of CTS in BD patients. MATERIALS AND METHODS: Retrospective analysis of the medical records of 1750 BD patients, and 14 (0.8%) BD patients who were diagnosed with CTS was performed at the BD Specialty Clinic of Severance Hospital. Patient demographics, disease activity/severity for both diseases, and the clinical characteristics of CTS in BD were recorded and analyzed. RESULTS: All 14 BD patients with CTS were women. Twelve patients (85.7%) were diagnosed with active BD. The CTS was mild in 8 patients (57.2%), moderate in 3 patients (21.4%), and severe in 3 patients (21.4%). Ten patients (71.4%) had BD prior to the diagnosis of CTS, and these 10 patients all had active BD. CONCLUSION: CTS can occur as a result of the inflammation associated with BD and can also be the presenting symptom of nerve involvement in BD. CTS can also develop as the initial symptom of BD. Therefore, a higher degree of suspicion should be maintained for CTS in patients with BD and vice versa; however, the exact relationship is uncertain.
Adult
;
Age Distribution
;
Aged
;
Behcet Syndrome/complications/diagnosis/*epidemiology
;
Carpal Tunnel Syndrome/diagnosis/*epidemiology
;
Female
;
Humans
;
Inflammation
;
Male
;
Middle Aged
;
Retrospective Studies
;
Sex Distribution
2.The Prevalence and Clinical Characteristics of Esophageal Involvement in Patients with Behcet's Disease: A Single Center Experience in Korea.
Seung Woo YI ; Jae Hee CHEON ; Jie Hyun KIM ; Sang Kil LEE ; Tae Il KIM ; Yong Chan LEE ; Won Ho KIM
Journal of Korean Medical Science 2009;24(1):52-56
While a significant amount of clinical information has been reported concerning intestinal involvement in Behcet's disease (BD), esophageal involvement in BD has not yet been studied extensively. The aim of this study was to evaluate the prevalence of esophageal involvement in BD and its clinical characteristics. We retrospectively reviewed the medical records of 842 patients diagnosed with BD at a single tertiary institution in Korea between January 1990 and June 2006. Of the 842 patients with BD, 129 patients (15.3%) experienced upper gastrointestinal symptoms that required inspection through esophagogastroduodenoscopy. Esophageal involvement was found in 6 (4.7%) of the 129 patients. The activity index of Behcet's disease did not differ among patients with or without esophageal involvement. All patients with esophageal involvement responded well to medical treatment and no one experienced serious complications. The results of our study demonstrate that the prevalence of esophageal involvement in BD is very low and that most patients with such involvement face few complications and respond well to medical treatment.
Adolescent
;
Adult
;
Aged
;
Behcet Syndrome/*complications/diagnosis/epidemiology
;
Child
;
Child, Preschool
;
Endoscopy, Digestive System
;
Esophageal Diseases/diagnosis/epidemiology/*etiology
;
Female
;
Humans
;
Korea
;
Male
;
Medical Records
;
Middle Aged
;
Prevalence
;
Retrospective Studies
3.Renal Manifestations in 2007 Korean Patients with Behcet's Disease.
Sung Bin CHO ; Jihyun KIM ; Shin Wook KANG ; Tae Hyun YOO ; Zhenlong ZHENG ; Suhyun CHO ; Hye Sun LEE ; Dongsik BANG
Yonsei Medical Journal 2013;54(1):189-196
PURPOSE: Behcet's disease (BD) theoretically affects all sizes and types of blood vessels and results in multi-organ involvement. However, renal BD has not been fully characterized, though the kidneys are histologically rich in blood vessels. MATERIALS AND METHODS: A total of 2007 patients who fulfilled the diagnostic criteria for BD were enrolled in this study. We reviewed the medical records and test results of the BD patients and used univariate and multivariate logistic regression analyses to determine the clinical significance of renal involvement in BD. RESULTS: Among the 2007 BD patients, we noted hematuria in 412 (20.5%) and proteinuria in 29 (1.4%). Univariate analysis showed that the BD patients with hematuria were predominantly female and older, had higher erythrocyte sedimentation rates (ESRs), and more frequently presented with genital ulcerations. BD patients with proteinuria had higher ESR levels compared to BD patients without proteinuria. In the multivariate analysis, age, sex, and ESR were found to be significantly associated with hematuria in BD patients, whereas only ESR was associated with proteinuria in BD patients. We also found that IgA nephropathy was the most common pathologic diagnosis in 12 renal BD patients who underwent renal biopsies. CONCLUSION: We suggest that routine urinalysis and serum renal function tests be performed for the early detection of renal BD, especially in older female BD patients with recurrent hematuria, high ESR levels, and frequent genital ulcers, as well as in BD patients with proteinuria and high ESR levels.
Adolescent
;
Adult
;
Age Factors
;
Aged
;
Aged, 80 and over
;
Behcet Syndrome/*complications/epidemiology/*metabolism
;
Biopsy
;
Female
;
Glomerulonephritis, IGA/complications/diagnosis
;
Hematuria/complications/diagnosis
;
Humans
;
Kidney/*pathology
;
Kidney Diseases/*diagnosis
;
Logistic Models
;
Male
;
Middle Aged
;
Multivariate Analysis
;
Proteinuria/complications/diagnosis
;
Republic of Korea
;
Young Adult