We Report a hibernoma which ocurred in a 30-year-old male, who had 2cm sized, well-marginated, subcutaneous mass on the right side of the scapula. Histopathologic finding showed the tumor was composed of uniform granular or multivacuolated, eosinophilic, round to ovoid cells with small and peripherally plnced nuclei. Total exrision of the tumor was performed. No recurrence was observed for 5 months after surgical excision.
Adult ; Eosinophils ; Humans ; Lipoma* ; Male ; Recurrence ; Scapula

The disc internal disruption syndrome is not well known to us, but the following hypothesis is widely accepted in clinical practice. The disc internal disruption syndrome may develop intractable back pain with aggravated of pain, loss of spinal motion with any physical exercise, leg pain, loss of energy, marked weight loss, and profound depression. The patient with this syndrome will be found to have normal plain roentgenograms, myelograms, CT scans, results of blood examination and neurologic findings. For these reasons, this syndrome was frequently diagnosed by abnormal discographic findings. We had experience with two cases of disc internal disruption syndrome with clinical, roentgenographic and discographic evaluations. Thus we present these case with a brief review of the concerned literature.
Back Pain ; Depression ; Exercise ; Humans ; Leg ; Neurologic Manifestations ; Tomography, X-Ray Computed ; Weight Loss

No abstract available.
Animals ; Germinal Center* ; Lymph Nodes* ; Mice*

Human papillomavirus (HPV)infection are now generally accepted as the most important factor for development of uterine cervical cancer and its precursor lesions. With increasing evidences that the HPV E7 encodes for oncoproteins critical for viral replication, host cell immortalization and transformation. Based on the previous reports that the high risk HPV type 16 DNA is frequently detected in specimens from Korean women with cervical cancer and that there is the sequence variation and geographical dependence of HPV 16 E7 gene in preinvasive and invasive cervical lesions, it is crucial to determine the prevalence of HPV 16 variants in uterine cervical lesions of Korean women. This study was performed to identify sequence variations of HPV 16 E7 gene and an association between HPV 16 E7 variants and uterine cervical cancer. The author has determined nucleotide sequences of the E7 gene of HPV 16 isolated from uterine cervical tissues in Korean women. HPV 16 DNAs were detected by the nested PCR in 112 (24.5%) of a total of 457 samples. By direct sequencing of PCR-HPV 16 E7 positive cases, 79 samples (70.5%) showed variant sequences, while the prototype sequence was found in only 33 samples (29.5%). Twenty-three cases (57.5%) of 40 normal cervical samples showed sequence variation. Forty-eight (77.4%) of 62 cervical cancer cases showed sequence diversity from prototype HPV 16 E7 gene. There were four types of sequence variations. A single nucleotide change at position 647 (A-->G) was found in 52 cases (65.8%) of 79 HPV 16 E7 variants. Predicted amino acid change (Asn -->Ser) was found in the HPV 16 E7 oncoproteins at amino acid position at 29. And this KE7-1 variant was commonly detected in the uterine cervical cancer compared to the normal cervix. The second most common variant, detected in 16 cases (20.3%), had three silent mutations at nucleotide positions 732 (T-->C), 789 (T-->C) and 795 (T-->G). The third variant had a single nucleotide change at position 666 (G-->A), and the fourth had a change at position 796 (T-->C). Furthermore, PCR-SSCP clearly showed distinct bands compatible with HPV 16 E7 variants as with the direct-sequencing method. PCR-SSCP was also an effective and reliable tool in detecting HPV 16 E7 variants. This study showed that there were four variant types of HPV 16 E7 in uterine cervical tissues and KE7-1 with corresponding amino acid change was the most commonly detected type in E7 variants of HPV 16 isolated from uterine cervical cancer in Korean women.
Base Sequence ; Cervix Uteri ; DNA ; Female ; Human papillomavirus 16 ; Humans* ; Oncogene Proteins ; Polymerase Chain Reaction ; Polymorphism, Genetic* ; Prevalence ; Uterine Cervical Neoplasms*

No abstract available.
Fingers* ; Toes*

No abstract available.
Fingers* ; Toes*

BACKGROUND: In autoimmune bullous dermatoses, such as pemphigus and bullous pemphigoid, variations in the expression of the antigen in different body locations are recognized. OBJECTIVE: The degree of expession of epidermolysis bullosa acquisita (EBA) antigen in different sites on the body surface was estimated from the highest dilution factor of EBA sera that gave a positive reaction at a site by indirect immunofluorescence (IF). METHODS: Two sera, obtained from EBA patients with inflammatory and mechanobullous skin lesions, having antihody titers of 160 against the dermal component of the NaCl split skin, were used by indirect IF techniques with 20 specimens (2 from each of 10 locations) of normal human skin from different sites. These 20 skin samples were obtained from 10 healthy adults (1-3 from each individual). RESULTS: The greatest expression of the antigen was in the skin taken from the upper back with the titer of 160. EBA antigen was least recognized in skin specimens from the inner thigh and calf. Skin from the scalp, abdomen, and anterior chest and others demonstrated intermediate degrees of expression. CONCLUSION: There was some moderate degree of variation in the expression of EBA antigens in skin samples obtained from different locations on the body. It seems however that there is not any positive correlation between the degree of expression of EBA antigen in each location and predilection sites (possibly the trunk) of clinical lesions in EBA.
Abdomen ; Adult ; Epidermolysis Bullosa Acquisita* ; Epidermolysis Bullosa* ; Fluorescent Antibody Technique, Indirect ; Humans ; Pemphigoid, Bullous ; Pemphigus ; Scalp ; Skin ; Skin Diseases, Vesiculobullous ; Thigh ; Thorax

No abstract available.
Discrimination (Psychology)* ; Foot*

In recent years active research on sexual anomalies, especially on the conditionsof intersex is rapidly progressing. It is not until Barr et al, have clarifiedthe epochmaking discovery of sex chromosome test that the concept of chromosomalintersex was firmly established. Reported here are 6 cases of intersex admittedto the Department of Urology, Seoul National University Hospital. Aceerding tothe results of observation on the sex chromatin. external or internal genitalia,in some, hormonal balance, utilizing various methods of urological examination, 6 cases of intersex have been confirmed. These patients consist of 1 case of truehermaphroditism, 2 cases of male pseudohermaphroditism. 2 cases of femalepseudohermaphroditism with congenital adrenogenital syndrome and one case ofKinefelter's syndrome. In summary the first case of true hermspbroditismapparently looked like a hypospadiac male with atrophied testis as gonad but afterpuberty the ovarian activity became manifest and gynecomastia developed. Therefore is out of the question that this case is a true hermaprodite possessing bothtestis and ovary. Considering this patient's sex of rearing, correction of hypospadia was performed. This patient leads his social life by virtue oftestosterone supply. The second case is a male pseudohermaphroditism patientconfirmed by exploratory laparotomy which revealed degenerative change of femalegonads and reproductive organ. However, the active gonad was testis andaccordingly it is apparent that this is a male pseudohermaphroditism case. Thispatient had the hope to live as a female. Therefore according to the patient's own wish, hypospadia correction plus phallectomy and vaginoplasty were performedand was feminized. Estrogen therapy has been received, but masculinizing symptomsare still present. The 3rd case had severe hypospadia with cryptorchism. Theexternal appearance, however, was like that of a female. Laparotomy revealed no gonads or reproductive organ. Biopsy revealed atrophic testis. Therefore thediagnosis of sale pseudohermaphroditism was made. This child was performedhypospadia correction and was decided to be reared as a male. The 4th case afirmly established adrenogenital syndrome patient, has received clitoridectomyand cortisone therapy was indicated and is under observation. The 5th case alsois a child with adrenogenital syndrome. Bilateral partial adrenalectomy wasperformed and simultaneously cortisone therapy was continued. However, clinical manifestations of Cushing's syndrome appeared because of overdosage of cortisone. In this case, clitoridectomy and vaginoplasty were performed. The 6th patient was a chromosomal intersex. Chromosomal test was positive and large gynecomastia was present. Testicular biopsies revealed characteristic findings of the Klinefelter's syndrome. There were hyalinzed seminiferous tubules, hypertrophy of the basement membrane, and an increased number of interstitial cells appearing in clumps. Testosterone therapy was performed to correct mental symptoms and decreased libido. Gynecomastia is to be removed surgically. It is important on the diagnosis of intersex to confirm the existence of urogenital sinus. Urogenital sinus was present in 4 of our cases. As with 2nd case, adaptability of patients with intersex will be more secure to make the social sex as a female than to make it as a male. Recent related literatures were reviewed.
46, XY Disorders of Sex Development ; Adrenalectomy ; Adrenogenital Syndrome ; Basement Membrane ; Biopsy ; Child ; Circumcision, Female ; Commerce ; Cortisone ; Cryptorchidism ; Cushing Syndrome ; Diagnosis ; Disorders of Sex Development ; Estrogens ; Female ; Gonads ; Gynecomastia ; Hope ; Humans ; Hypertrophy ; Hypospadias ; Klinefelter Syndrome ; Laparotomy ; Libido ; Male ; Ovary ; Seminiferous Tubules ; Seoul ; Sex Chromatin ; Sex Chromosomes ; Testis ; Testosterone ; Urology ; Virtues

No abstract available.
17-alpha-Hydroxyprogesterone*