Introduction: Sexually transmitted infections (STIs) are common in the developing countries. Sexually transmitted infections are among the most important causes of spontaneous abortion, premature rupture of membranes, preterm delivery, stillbirth, low birth weight, neonatal infection and postpartum endometritis and a major public health problem in the world.Goal: The goal of this study is to search peculiarity of delivery in women with STI.Materials and Methods: This study is a prospective cohort study which was done 2009-2010. In this study 120 pregnant women were involved. In case group were attended 60 women with STI and 60 women without STI in control group. The 40 pregnant women of case group (I group) were done treatment of STI and 20 pregnant women of case group (II group) were not done treatment of STI. All women were diagnosed with STI including syphilis, gonorrhea, Chlamydia and trichomoniasis. Statistical analysis has been done by SPSS 13.0 programm.Results: Mean gestational age at the first antenatal visit in I group was significantly earlier than in group II (13.5±4.5 weeks and 18.8±7.2 weeks respectively; p=0.005) but was similar to that of control group (13.6±5.2 weeks; P not significant). The frequency of preterm delivery and PROM was significantly lower in group I (12.5%, 17.5% respectively) than group II (30.0%, 40.0% respectively). In terms of II group preterm delivery and PROM were from 4 to 5 times more in comparison to control group. Low birth weight was significantly lower in women of group I (17.5%) than group II (30.0%; p=0.04) and in group II was 3 times more in comparison to control group(11.7%; p=0.008). Conclusions: The frequency of premature delivery, PROM, low birth weight were higher in the pregnant women who untreated STI. The first pprenatal visit is late and prenatal care inadequate were cause untreated in the pregnant women with STI.

Background: Nurses spend the most time with patients when providing medical care, making them a crucial factor in ensuring appropriate and effective treatment. Their assessment skills play a vital role in pain management. Aim: This study aims to determine the validity and reliability of the Mongolian version of the Knowledge and Attitudes Survey Regarding Pain (KASRP). Materials and Methods: A cross-sectional, quantitative study was conducted using the Knowledge and Attitudes Survey Regarding Pain (KASRP) questionnaire. A total of 145 nurses from the surgical, emergency, and intensive care units of the National Trauma and Orthopedic Research Center (NTORC), the National Cancer Center of Mongolia (NCCM), and the National Center for Maternal and Child Health (NCMCH) participated in the study. Statistical analysis was performed using SPSS-25 software. Results: The study included 115 female and 30 male nurses, with an average age of 37.21±7.50 years and an average work experience of 13.43±7.57 years. The face validity index (FVI) for each item ranged from 0.81 to 1.00. The content validity index (CVI) for each item ranged from 0.66 to 1.00. The internal consistency of the questionnaire was assessed using Cronbach’s alpha, which was found to be 0.88. Conclusion The Mongolian version of the KASRP demonstrates satisfactory face validity, content validity, and reliability, making it suitable for practical application.

Introduction: The aim of this research project is to elucidate the crosstalk of innate and adaptive immune reactions against the DNA containing bacteria. : This study held in the Core laboratory, Science Technology Center, Mongolian National University of Medical Sciences (MNUMS). Murine aortal endothelial cells, END-D cultured and the cell viability checked by MTT assay. In addition, the NO production, protein and gene expression studied by Griess Reagent assay, R.T-PCR and immunoblotting, respectively. Results: 0.1µM, 1µM and 10µM of TLR9 ligand exhibited no cytotoxic action against the cells by MTT assay. IFN-ү alone induced NO production in END-D cells. In the other hand, TLR9 ligand at 0.1µM, 1µM and 10µM up-regulated IFN-ү induced NO production in dose dependent manner. RTPCR results exhibit that TLR9 ligand up regulates iNOS mRNA. Immunoblotting analysis showed the enhanced iNOS protein expression and phosphorylation of STAT1 in cells pre-treated with TLR9 ligand. Discussion: We have demonstrated CpG DNA, TLR9 ligand, up-regulates IFN-ү induced NO via enhanced IFN-ү signaling. The result of Western Blotting and RT-PCR support the up-regulation of NO. CpG DNA can be used as agent against virus and bacteria. Further research need to be conducted. Conclusion TLR9 ligand, CpG DNA up-regulates IFN-ү induced NO production in time and dose dependent manner. TLR9 ligand augments the expression of iNOS mRNA and STAT1 phosphorylation in response to IFN-ү.