1.Effects of some syrups on citric acid induced cough in rat
Munkh-Erdene R ; Davaasambuu V ; Bat-Oyun U ; Ahsholpan B ; Badamtsetseg S ; LKhaasuren R ; Hurelbaatar L
Mongolian Pharmacy and Pharmacology 2023;23(2):20-25
Abstract:
In Mongolia, flu and flu-like diseases affect many people, and pneumonia is a public health concern. Therefore, we have an urgent need to research and develop a new medicinal syrup to replace imported products using raw materials grown in Mongolia and to compare it with similar products. There are imported cough syrup products on the pharmaceutical market of Mongolia, but there are domestic pharmaceutical products. Moreover, there is limited research data on cough relief. The main goal of the research team is to compare the experimentally obtained syrup containing Plantago asiatica L, Malva Sylvestris L. and syrup containing Plantago major L. Juice, honey that produced by Monos Pharm LLC whish the cough relieving drug Gerbion syrup.
Material and methods:
The vivarium of the pharmacology laboratory, Drug research institute,
TPC7062Ti mark IVC system (Shanghai Pretty Industries Co.,Ltd, China) in a special environment
with one care and one feeding regimen (Lab Mice Diet, Constant Formula Balanced Nutrition,
Jiangsu Xietong Pharmaceutical Bio- Engineering Co., LTD, China, www.jsxtsw.com ) used 64
non-WISTAR white rats weighing 180-218 g. Experimental rats were smoked with an aerosol of
17% citric acid aqueous solution for 5 minutes. The statistical processing of the research results
was done using the One-Way ANOVA/Multiple comparisons data of the GraphPad Prism 8 program.
Results and conclusion
Expressing the number of coughs produced in the experimental rats as
a percentage (%), the control group showed 3.95% cough relief, and the experimental group-1 by
48.4%, experimental group-2 by 71.1%, comparison group by 74.6%, respectively has reduced.
Experimental group -2 and comparison group for dry cough caused by citric acid 17%, it affects
the cough receptors in the mucous membrane of the respiratory tract and relaxes the bronchial
muscles (A and C fiber).
2.To elucidate the action mechanism of Tumrinn Talkh-7 in liver’s smug po disease from the literature
Bat-Oyun U ; Ulaan-Оd Kh ; Enkhbold G ; Badamtsetseg S ; Lkhaasuren R ; Bold Sh ; Khurelbaatar L
Mongolian Pharmacy and Pharmacology 2024;25(2):18-23
Background:
Diseases of the digestive system are one of the leading causes of global morbidity, and liver disease is
the leading cause, accounting for 52.34% of 100,000 population in Asian countries. In Mongolia, cirrhosis
accounted for 32.4% of all liver diseases in 2019.
In traditional medical treatment, liver cirrhosis is included in the scope of chronic diseases and compared with liver’s smug po disease for treatment. In this study, we aimed to clarify the mechanism of action of Tumrinn talkh-7, which is widely used in the treatment of liver diseases, especially in the treatment of liver diseases.
Materials and methods:
In our study, we used the book named “Oral Instruction Tantra” as main reference material and for research methods, we used the checklist method to list relevant information about the pathogenesis of liver smug po and Tumriin Talkh-7 traditional drug from the literature, so as to provide preconditions for further analysis. The pathogenesis of liver smug po and the action mechanism of Tumriin Talkh-7 were analyzed by theoretical analysis methods and the analysis-synthesis method was used to summarize the analysis results.
Results:
Due to the hot conditions, the blood heat will increase occur. Due to the cold conditions, food absorption is
impaired bad blood is formed in the liver. This is how Smug po disease occurs.
Tumriin talkh-7 traditional drugs should be analyzed in relation to the transformation of liver smug po disease.
Iron dust is treating heat liver smug po removed.
Calcitu-CaCO3 is clear phlegm heat.
Dracocephallum foetidum Bge. is cures stomach and liver heat.
Inula helenium L. is equable and cures all liver Smug po diseases.
Saussurea lappa L. is sharp, warm nature, regulating wind-blood disorder.
Trogopterus xanthipes mine Edwards is treating old liver disease.
Carthamus tinctorius L. is saffron cures all liver diseases.
Conclusions
Pathological blood caused by cold and heat factors leads to liver smug po disease. Tumriin Talkh-7 is a cold
drug with the effect of treating hot liver smug po disease.